{"id":119728,"date":"2026-10-30T00:19:25","date_gmt":"2026-10-29T23:19:25","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=119728"},"modified":"2026-10-29T12:33:44","modified_gmt":"2026-10-29T11:33:44","slug":"bakterie-ze-streva-zaby-zpusobuje-uplne-vymizeni-rakovinnych-nadoru-a-ve-studiich-na-zviratech-dokonce-prekonava-chemoterapii","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/10\/30\/bakterie-ze-streva-zaby-zpusobuje-uplne-vymizeni-rakovinnych-nadoru-a-ve-studiich-na-zviratech-dokonce-prekonava-chemoterapii\/","title":{"rendered":"Bakterie ze st\u0159eva \u017e\u00e1by zp\u016fsobuje \u00fapln\u00e9 vymizen\u00ed rakovinn\u00fdch n\u00e1dor\u016f \u2013 a ve studi\u00edch na zv\u00ed\u0159atech dokonce p\u0159ekon\u00e1v\u00e1 chemoterapii"},"content":{"rendered":"
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Japon\u0161t\u00ed v\u011bdci oznamuj\u00ed pozoruhodn\u00fd pr\u016flom v experiment\u00e1ln\u00edm v\u00fdzkumu rakoviny: Jedin\u00e1 injekce p\u0159irozen\u011b se vyskytuj\u00edc\u00ed bakterie eliminovala n\u00e1dory u v\u0161ech l\u00e9\u010den\u00fdch my\u0161\u00ed. Srovn\u00e1n\u00ed se zaveden\u00fdmi l\u00e9ky proti rakovin\u011b je obzvl\u00e1\u0161t\u011b pozoruhodn\u00e9.<\/span><\/strong><\/p>\n

Studie<\/span><\/a> publikovan\u00e1 v prosinci 2025 v \u010dasopise Gut Microbes japonsk\u00fdmi v\u011bdci by mohla otev\u0159\u00edt novou cestu v l\u00e9\u010db\u011b rakoviny. V\u00fdzkumn\u00edci z Japonsk\u00e9ho pokro\u010dil\u00e9ho institutu pro v\u011bdu a technologii (JAIST) objevili bakterii ve st\u0159ev\u011b japonsk\u00e9 rosni\u010dky, kter\u00e1 ve studi\u00edch na zv\u00ed\u0159atech vykazovala v\u00fdjime\u010dn\u00e9 protirakovinn\u00e9 \u00fa\u010dinky.<\/span><\/p>\n

V experiment\u00e1ln\u00edm modelu rakoviny tlust\u00e9ho st\u0159eva bakterie Ewingella americana eliminovala v\u0161echny n\u00e1dory u l\u00e9\u010den\u00fdch my\u0161\u00ed \u2013 a to ji\u017e po jedin\u00e9 intraven\u00f3zn\u00ed injekci.<\/span><\/p>\n

Je\u0161t\u011b pozoruhodn\u011bj\u0161\u00ed je, \u017ee v p\u0159\u00edm\u00e9m srovn\u00e1n\u00ed s chemoterapeutikem doxorubicinem a modern\u00ed imunoterapi\u00ed s protil\u00e1tkami proti PD-L1 dos\u00e1hla bakterie v\u00fdrazn\u011b lep\u0161\u00edch v\u00fdsledk\u016f.<\/span><\/p>\n

V sou\u010dasn\u00e9 dob\u011b se v\u0161ak jedn\u00e1 pouze o preklinick\u00fd v\u00fdzkum. Zda lze tyto v\u00fdsledky aplikovat na lidi, je st\u00e1le zcela nejasn\u00e9.<\/span><\/p>\n

Objev ve st\u0159evech \u017eab, \u010dolk\u016f a je\u0161t\u011brek<\/span><\/h2>\n

V\u011bdci pod veden\u00edm Eijira Miyaka zkoumali st\u0159evn\u00ed bakterie t\u0159\u00ed \u017eivo\u010di\u0161n\u00fdch druh\u016f: japonsk\u00e9 rosni\u010dky (Dryophytes japonicus), japonsk\u00e9ho \u010dolka ohniv\u00e9ho (Cynops pyrrhogaster) a japonsk\u00e9ho druhu je\u0161t\u011brky (Takydromus tachydromoides).<\/span><\/p>\n

Celkem izolovali 45 bakteri\u00e1ln\u00edch kmen\u016f. Po \u00favodn\u00ed bezpe\u010dnostn\u00ed kontrole vybrali dev\u011bt kandid\u00e1t\u016f pro dal\u0161\u00ed zkoum\u00e1n\u00ed.<\/span><\/p>\n

Studie uk\u00e1zala, \u017ee n\u011bkolik z t\u011bchto mikroorganism\u016f dok\u00e1zalo inhibovat r\u016fst rakovinn\u00fdch n\u00e1dor\u016f. T\u0159i bakteri\u00e1ln\u00ed kmeny dokonce zp\u016fsobily regresi n\u00e1dor\u016f. Ve dvou z t\u011bchto p\u0159\u00edpad\u016f se v\u0161ak rakovina po kr\u00e1tk\u00e9 dob\u011b vr\u00e1tila.<\/span><\/p>\n

Naproti tomu Ewingella americana: Bakterie izolovan\u00e1 z evropsk\u00e9 rosni\u010dky vedla k \u00fapln\u00e9 a trval\u00e9 regresi n\u00e1doru.<\/span><\/p>\n

V\u011bdci podali jednu injekci bakterie my\u0161\u00edm, kter\u00fdm byly p\u0159edt\u00edm nao\u010dkov\u00e1ny n\u00e1dory tlust\u00e9ho st\u0159eva 26. Pot\u00e9 pozorovali v\u00fdvoj n\u00e1dor\u016f a zdravotn\u00ed stav zv\u00ed\u0159at.<\/span><\/p>\n

V\u00fdsledek: U v\u0161ech my\u0161\u00ed l\u00e9\u010den\u00fdch Ewingella americana n\u00e1dory zcela zmizely. M\u00edra p\u0159e\u017eit\u00ed ve studovan\u00e9 skupin\u011b byla 100 procent.<\/span><\/p>\n

P\u0159\u00edm\u00e9 srovn\u00e1n\u00ed s chemoterapi\u00ed a imunoterapi\u00ed<\/span><\/h2>\n

Obzvl\u00e1\u0161t\u011b zaj\u00edmav\u00e1 je \u010d\u00e1st studie, ve kter\u00e9 v\u011bdci porovn\u00e1vali svou bakteri\u00e1ln\u00ed l\u00e9\u010dbu se dv\u011bma zaveden\u00fdmi l\u00e9ky na rakovinu.<\/span><\/p>\n

Pou\u017eili stejn\u00fd my\u0161\u00ed model a zkoumali t\u0159i r\u016fzn\u00e9 l\u00e9\u010debn\u00e9 p\u0159\u00edstupy.<\/span><\/p>\n

\n\n\n\n\n\n\n
Zach\u00e1zen\u00ed<\/span><\/th>\nV\u00fdsledek experimentu na my\u0161i<\/span><\/th>\n<\/tr>\n
Ewingella americana \u2013 injekce<\/span><\/td>\n100% kompletn\u00ed regrese n\u00e1doru (5 z 5 my\u0161\u00ed)<\/span><\/td>\n<\/tr>\n
Imunoterapie proti PD-L1 \u2013 \u010dty\u0159i injekce<\/span><\/td>\n20% kompletn\u00ed regrese n\u00e1doru (1 z 5 my\u0161\u00ed)<\/span><\/td>\n<\/tr>\n
Lipozom\u00e1ln\u00ed doxorubicin \u2013 \u010dty\u0159i injekce<\/span><\/td>\nBez \u00fapln\u00e9 regrese n\u00e1doru (0 z 5 my\u0161\u00ed)<\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/figure>\n

Zat\u00edmco doxorubicin a imunoterapie zpomalily r\u016fst n\u00e1doru, bakterie dok\u00e1zala u v\u0161ech p\u011bti l\u00e9\u010den\u00fdch zv\u00ed\u0159at n\u00e1dory zcela eliminovat.<\/span><\/p>\n

V\u011bdci tak\u00e9 zjistili, \u017ee o\u0161et\u0159en\u00ed jedinou bakteri\u00ed prodlou\u017eilo dobu p\u0159e\u017eit\u00ed nejm\u00e9n\u011b o 30 dn\u00ed ve srovn\u00e1n\u00ed s neo\u0161et\u0159enou kontroln\u00ed skupinou.<\/span><\/p>\n

Tyto v\u00fdsledky jsou pozoruhodn\u00e9. Srovn\u00e1vac\u00ed skupiny v\u0161ak byly mal\u00e9, ka\u017ed\u00e1 se skl\u00e1dala pouze z p\u011bti zv\u00ed\u0159at, a byl pou\u017eit pouze jeden specifick\u00fd experiment\u00e1ln\u00ed model n\u00e1doru. Nelze proto konstatovat, \u017ee bakteri\u00e1ln\u00ed l\u00e9\u010dba je u lidsk\u00fdch rakovin \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e chemoterapie.<\/span><\/p>\n

Jak bakterie bojuje s rakovinn\u00fdmi bu\u0148kami<\/span><\/h2>\n

V\u011bdci identifikovali dva kl\u00ed\u010dov\u00e9 mechanismy \u00fa\u010dinku.<\/span><\/p>\n

Za prv\u00e9, Ewingella americana m\u016f\u017ee p\u0159\u00edmo po\u0161kozovat rakovinn\u00e9 bu\u0148ky. Bakterie je fakultativn\u011b anaerobn\u00ed, co\u017e znamen\u00e1, \u017ee m\u016f\u017ee p\u0159e\u017e\u00edt jak s kysl\u00edkem, tak i bez n\u011bj. To j\u00ed d\u00e1v\u00e1 vlastnosti, kter\u00e9 j\u00ed umo\u017e\u0148uj\u00ed kolonizovat n\u00e1dorovou tk\u00e1\u0148 bez kysl\u00edku.<\/span><\/p>\n

Za druh\u00e9, aktivuje vlastn\u00ed imunitn\u00ed obranu t\u011bla. V\u011bdci pozorovali zv\u00fd\u0161en\u00e9 zapojen\u00ed T bun\u011bk, B bun\u011bk a neutrofil\u016f v boji proti n\u00e1dor\u016fm.<\/span><\/p>\n

Bakterie tak nejen p\u0159\u00edmo p\u016fsob\u00ed proti rakovinn\u00fdm bu\u0148k\u00e1m, ale z\u00e1rove\u0148 mobilizuje imunitn\u00ed syst\u00e9m.<\/span><\/p>\n

Obzvl\u00e1\u0161t\u011b zaj\u00edmav\u00fd byl dal\u0161\u00ed experiment: my\u0161\u00edm, jejich\u017e n\u00e1dory v d\u016fsledku bakteri\u00e1ln\u00ed l\u00e9\u010dby zmizely, byly znovu pod\u00e1ny rakovinn\u00e9 bu\u0148ky.<\/span><\/p>\n

U \u017e\u00e1dn\u00e9ho z deseti d\u0159\u00edve \u00fasp\u011b\u0161n\u011b l\u00e9\u010den\u00fdch zv\u00ed\u0159at se nevyvinuly nov\u00e9 n\u00e1dory. Naproti tomu u v\u0161ech deseti nel\u00e9\u010den\u00fdch kontroln\u00edch zv\u00ed\u0159at se n\u00e1dory vyvinuly.<\/span><\/p>\n

To nazna\u010duje, \u017ee l\u00e9\u010dba dok\u00e1zala u studovan\u00e9ho my\u0161\u00edho modelu spustit d\u00e9le trvaj\u00edc\u00ed imunologickou pam\u011b\u0165. V\u011bdci pozorovali tuto ochranu po dobu del\u0161\u00ed ne\u017e 60 dn\u00ed.<\/span><\/p>\n

M\u00e9n\u011b vedlej\u0161\u00edch \u00fa\u010dink\u016f ne\u017e u konven\u010dn\u00ed l\u00e9\u010dby rakoviny?<\/span><\/h2>\n

Dal\u0161\u00ed d\u016fle\u017eitou sou\u010d\u00e1st\u00ed studie byla sn\u00e1\u0161enlivost l\u00e9\u010dby.<\/span><\/p>\n

V\u011bdci mimo jin\u00e9 zkoumali t\u011blesnou hmotnost zv\u00ed\u0159at a jejich celkov\u00fd zdravotn\u00ed stav. P\u0159esto\u017ee bezprost\u0159edn\u011b po injekci do\u0161lo k m\u00edrn\u00e9mu \u00fabytku hmotnosti, co\u017e by mohlo nazna\u010dovat do\u010dasnou z\u00e1n\u011btlivou reakci, v n\u00e1sledn\u00e9m pr\u016fb\u011bhu studie nebyly mezi l\u00e9\u010debn\u00fdmi skupinami pozorov\u00e1ny \u017e\u00e1dn\u00e9 v\u00fdznamn\u00e9 rozd\u00edly v t\u011blesn\u00e9 hmotnosti.<\/span><\/p>\n

V\u00fdzkumn\u00edci uv\u00e1d\u011bj\u00ed, \u017ee zkouman\u00fd bakteri\u00e1ln\u00ed kmen vykazoval v my\u0161\u00edm modelu p\u0159i terapeuticky \u00fa\u010dinn\u00fdch d\u00e1vk\u00e1ch pouze n\u00edzk\u00fd patogenn\u00ed \u00fa\u010dinek.<\/span><\/p>\n

To v\u0161ak neznamen\u00e1, \u017ee bakterie je obecn\u011b ne\u0161kodn\u00e1. Ewingella americana je tak\u00e9 zn\u00e1m\u00e1 jako oportunn\u00ed patogen a ji\u017e byla spojov\u00e1na s infekcemi u novorozenc\u016f a imunokompromitovan\u00fdch jedinc\u016f.<\/span><\/p>\n

Zejm\u00e9na u pacient\u016f s rakovinou, jejich\u017e imunitn\u00ed syst\u00e9m je \u010dasto oslaben\u00fd, by proto bylo nutn\u00e9 pe\u010dliv\u011b prozkoumat, zda je intraven\u00f3zn\u00ed pod\u00e1v\u00e1n\u00ed \u017eiv\u00fdch bakteri\u00ed bezpe\u010dn\u00e9.<\/span><\/p>\n

Studie tak prokazuje dobrou sn\u00e1\u0161enlivost za zkouman\u00fdch experiment\u00e1ln\u00edch podm\u00ednek, ale zat\u00edm ne bezpe\u010dnost u lid\u00ed.<\/span><\/p>\n

Pro\u010d je tento objev d\u016fle\u017eit\u00fd pro v\u00fdzkum rakoviny<\/span><\/h2>\n

Vyu\u017eit\u00ed bakteri\u00ed k boji proti rakovin\u011b nen\u00ed zcela nov\u00e1 my\u0161lenka. V\u011bdci ji\u017e dlouho zkoumaj\u00ed, zda ur\u010dit\u00e9 mikroorganismy mohou specificky kolonizovat n\u00e1dorovou tk\u00e1\u0148 a m\u00edt v n\u00ed terapeutick\u00fd \u00fa\u010dinek.<\/span><\/p>\n

Dosavadn\u00ed v\u00fdzkum se \u010d\u00e1st tohoto v\u00fdzkumu zam\u011b\u0159ovala na geneticky modifikovan\u00e9 bakterie, jejich\u017e vlastnosti jsou upravov\u00e1ny v laborato\u0159i.<\/span><\/p>\n

Japon\u0161t\u00ed v\u011bdci zvolili jin\u00fd p\u0159\u00edstup: V p\u0159\u00edrod\u011b hledaj\u00ed existuj\u00edc\u00ed mikroorganismy, kter\u00e9 maj\u00ed inherentn\u00ed vlastnosti proti rakovin\u011b.<\/span><\/p>\n

To by mohlo v dlouhodob\u00e9m horizontu otev\u0159\u00edt nov\u00e9 mo\u017enosti, proto\u017ee genetick\u00e9 modifikace by nutn\u011b nebyly nutn\u00e9.<\/span><\/p>\n

Tento objev tak\u00e9 podtrhuje, jak m\u00e1lo je v sou\u010dasnosti zn\u00e1mo o l\u00e9ka\u0159sky u\u017eite\u010dn\u00fdch vlastnostech obrovsk\u00e9 mikrobi\u00e1ln\u00ed rozmanitosti.<\/span><\/p>\n

Znamen\u00e1 to pr\u016flom v boji proti rakovin\u011b?<\/span><\/h2>\n

V\u00fdsledky jsou v\u00fdjime\u010dn\u00e9, ale kl\u00ed\u010dov\u00e9 ot\u00e1zky z\u016fst\u00e1vaj\u00ed nezodpov\u011bzeny.<\/span><\/p>\n

Dosud nebylo prok\u00e1z\u00e1no, \u017ee Ewingella americana dok\u00e1\u017ee spolehliv\u011b eliminovat lidsk\u00e9 n\u00e1dory. Stejn\u011b tak nen\u00ed jasn\u00e9, zda l\u00e9\u010dba funguje i u jin\u00fdch typ\u016f rakoviny, jak\u00e9 d\u00e1vkov\u00e1n\u00ed by bylo u lid\u00ed nutn\u00e9 a jak\u00e1 rizika by mohla vzniknout p\u0159i syst\u00e9mov\u00e9m pod\u00e1v\u00e1n\u00ed.<\/span><\/p>\n

Srovn\u00e1n\u00ed s doxorubicinem a protil\u00e1tkami proti PD-L1 je tak\u00e9 t\u0159eba zasadit do spr\u00e1vn\u00e9 perspektivy: Skute\u010dnost, \u017ee bakterie funguje l\u00e9pe v konkr\u00e9tn\u00edm my\u0161\u00edm modelu, neznamen\u00e1, \u017ee by mohla nahradit dnes pou\u017e\u00edvan\u00e9 protin\u00e1dorov\u00e9 terapie u pacient\u016f.<\/span><\/p>\n

To by vy\u017eadovalo dal\u0161\u00ed preklinick\u00e9 studie a n\u00e1sledn\u00e9 kontrolovan\u00e9 klinick\u00e9 studie.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Japon\u0161t\u00ed v\u011bdci oznamuj\u00ed pozoruhodn\u00fd pr\u016flom v experiment\u00e1ln\u00edm v\u00fdzkumu rakoviny: Jedin\u00e1 injekce p\u0159irozen\u011b se vyskytuj\u00edc\u00ed bakterie…<\/p>\n","protected":false},"author":2,"featured_media":119729,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1020,1366,1561,11937],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/119728"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=119728"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/119728\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/119729"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=119728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=119728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=119728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}