{"id":115546,"date":"2026-09-11T00:11:46","date_gmt":"2026-09-10T22:11:46","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=115546"},"modified":"2026-09-10T08:16:35","modified_gmt":"2026-09-10T06:16:35","slug":"leky-pohanene-umelou-inteligenci-obraceji-biologicke-hodiny-vedci-hovori-o-moznem-prulomu","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/09\/11\/leky-pohanene-umelou-inteligenci-obraceji-biologicke-hodiny-vedci-hovori-o-moznem-prulomu\/","title":{"rendered":"L\u00e9ky poh\u00e1n\u011bn\u00e9 um\u011blou inteligenc\u00ed obracej\u00ed biologick\u00e9 hodiny \u2013 v\u011bdci hovo\u0159\u00ed o mo\u017en\u00e9m pr\u016flomu"},"content":{"rendered":"
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L\u00e9k vyvinut\u00fd s vyu\u017eit\u00edm um\u011bl\u00e9 inteligence by mohl nejen l\u00e9\u010dit z\u00e1va\u017en\u00e9 onemocn\u011bn\u00ed plic, ale tak\u00e9 ovlivnit biologick\u00e9 procesy st\u00e1rnut\u00ed. Nov\u00e1 studie v \u010dasopise\u00a0<\/span>Nature Biotechnology<\/span><\/em>\u00a0poskytuje prvn\u00ed klinick\u00fd d\u016fkaz. V\u00fdsledky jsou pozoruhodn\u00e9 \u2013 i kdy\u017e st\u00e1le neexistuj\u00ed \u017e\u00e1dn\u00e9 d\u016fkazy o lidsk\u00e9m omlazen\u00ed.<\/span><\/p>\n

L\u00e9\u010div\u00e1 l\u00e1tka rentosertib byla p\u016fvodn\u011b vyvinuta spole\u010dnost\u00ed\u00a0<\/span>Insilico Medicine<\/span><\/a>\u00a0k l\u00e9\u010db\u011b idiopatick\u00e9 plicn\u00ed fibr\u00f3zy. P\u0159i tomto z\u00e1va\u017en\u00e9m onemocn\u011bn\u00ed se plicn\u00ed tk\u00e1\u0148 postupn\u011b zjizvuje, co\u017e zhor\u0161uje p\u0159\u00edjem kysl\u00edku. Pomoc\u00ed um\u011bl\u00e9 inteligence spole\u010dnost nejprve identifikovala c\u00edlov\u00fd protein TNIK a pot\u00e9 navrhla vhodnou molekulu. Podle spole\u010dnosti uplynulo od identifikace c\u00edlov\u00e9ho proteinu k preklinick\u00e9mu kandid\u00e1tovi na l\u00e9\u010divo p\u0159ibli\u017en\u011b 18 m\u011bs\u00edc\u016f.<\/span><\/p>\n

\u0160est hodin ukazuje stejn\u00fdm sm\u011brem<\/span><\/h2>\n

Pro novou studii analyzovali v\u011bdci vzorky krve od 42 pacient\u016f ve f\u00e1zi IIa klinick\u00e9ho hodnocen\u00ed po dobu dvan\u00e1cti t\u00fddn\u016f. Zkoumali 2 841 protein\u016f a v\u00fdsledky vyhodnotili pomoc\u00ed \u0161esti nez\u00e1visle vyvinut\u00fdch \u201ev\u011bkov\u00fdch hodin\u201c zalo\u017een\u00fdch na proteinech.<\/span><\/p>\n

Tyto modely odhaduj\u00ed biologick\u00fd v\u011bk na z\u00e1klad\u011b specifick\u00fdch proteinov\u00fdch vzorc\u016f v krvi. Na rozd\u00edl od chronologick\u00e9ho v\u011bku m\u00e1 biologick\u00fd v\u011bk ud\u00e1vat, do jak\u00e9 m\u00edry je t\u011blo nebo jednotliv\u00e9 org\u00e1ny ji\u017e ovlivn\u011bno zm\u011bnami souvisej\u00edc\u00edmi s v\u011bkem.<\/span><\/p>\n

V\u00fdsledek:\u00a0<\/span>V\u0161ech \u0161est model\u016f prok\u00e1zalo sn\u00ed\u017een\u00ed odhadovan\u00e9ho biologick\u00e9ho v\u011bku pacient\u016f l\u00e9\u010den\u00fdch rentosertibem ve srovn\u00e1n\u00ed s placebem.<\/span><\/strong>\u00a0Nejsiln\u011bj\u0161\u00ed \u00fa\u010dinek byl pozorov\u00e1n po \u010dty\u0159ech t\u00fddnech p\u0159i d\u00e1vce 30 miligram\u016f dvakr\u00e1t denn\u011b. V z\u00e1vislosti na modelu odpov\u00eddala zm\u011bna p\u0159ibli\u017en\u011b t\u0159em a\u017e \u010dty\u0159em let\u016fm, v p\u0159\u00edpad\u011b m\u011b\u0159en\u00ed v\u011bku dokonce a\u017e \u0161esti let.<\/span><\/p>\n

V\u00edc ne\u017e jen zlep\u0161en\u00ed plicn\u00edch funkc\u00ed?<\/span><\/h2>\n

Obzvl\u00e1\u0161t\u011b zaj\u00edmav\u00e9 je, \u017ee k nejv\u011bt\u0161\u00edmu zlep\u0161en\u00ed plicn\u00edch funkc\u00ed nedo\u0161lo p\u0159i stejn\u00e9 d\u00e1vce jako nejsiln\u011bj\u0161\u00ed sign\u00e1l z biologick\u00fdch v\u011bkov\u00fdch hodin. V\u011bdci to pova\u017euj\u00ed za zn\u00e1mku toho, \u017ee rentosertib nemus\u00ed p\u016fsobit pouze l\u00e9\u010dbou plicn\u00edho onemocn\u011bn\u00ed, ale m\u016f\u017ee tak\u00e9 ovliv\u0148ovat nez\u00e1visl\u00e9 procesy souvisej\u00edc\u00ed s v\u011bkem.<\/span><\/p>\n

To by m\u011blo zna\u010dn\u00fd v\u00fdznam. V sou\u010dasn\u00e9 dob\u011b se medic\u00edna zam\u011b\u0159uje p\u0159edev\u0161\u00edm na l\u00e9\u010dbu jednotliv\u00fdch onemocn\u011bn\u00ed souvisej\u00edc\u00edch s v\u011bkem. L\u00e9k, kter\u00fd sou\u010dasn\u011b ovliv\u0148uje z\u00e1kladn\u00ed biologick\u00e9 procesy st\u00e1rnut\u00ed, by mohl otev\u0159\u00edt zcela nov\u00fd terapeutick\u00fd p\u0159\u00edstup.<\/span><\/p>\n

Zat\u00edm \u017e\u00e1dn\u00fd d\u016fkaz o obecn\u00e9m omlazen\u00ed<\/span><\/h2>\n

V\u00fdsledky je v\u0161ak nutn\u00e9 interpretovat s opatrnost\u00ed. Studie byla mal\u00e1, trvala pouze dvan\u00e1ct t\u00fddn\u016f a zkoumala v\u00fdhradn\u011b osoby s t\u011b\u017ek\u00fdm onemocn\u011bn\u00edm plic. Zlep\u0161en\u00ed zdravotn\u00edho stavu samo o sob\u011b mohlo zp\u016fsobit zm\u011bny v nam\u011b\u0159en\u00fdch ukazatel\u00edch v\u011bku, ani\u017e by ve skute\u010dnosti zvr\u00e1tilo celkov\u00fd proces st\u00e1rnut\u00ed.<\/span><\/p>\n

Kardiolog Eric Topol tak\u00e9\u00a0<\/span>zd\u016fraznil<\/span><\/a>\u00a0pro\u00a0<\/span>New York Times<\/span><\/em>\u00a0, \u017ee v\u00fdsledky jsou povzbudiv\u00e9, ale zat\u00edm neumo\u017e\u0148uj\u00ed definitivn\u00ed hodnocen\u00ed. Z\u00e1sadn\u00ed by byla odpov\u00eddaj\u00edc\u00ed studie u zdrav\u00fdch jedinc\u016f.<\/span><\/p>\n

Rentosertib tedy nen\u00ed prok\u00e1zan\u00fdm l\u00e9kem proti st\u00e1rnut\u00ed.<\/span><\/strong>\u00a0Studie v\u0161ak ukazuje, \u017ee aktivn\u00ed slo\u017eka vyvinut\u00e1 s vyu\u017eit\u00edm um\u011bl\u00e9 inteligence by mohla sou\u010dasn\u011b l\u00e9\u010dit onemocn\u011bn\u00ed a vyvolat m\u011b\u0159iteln\u00e9 zm\u011bny biomarker\u016f souvisej\u00edc\u00edch s v\u011bkem. Zda to skute\u010dn\u011b povede k prodlou\u017een\u00ed zdrav\u00e9ho \u017eivota, budou muset ur\u010dit dal\u0161\u00ed studie.<\/span><\/p>\n

V\u011bdeck\u00fd v\u00fdznam tedy nespo\u010d\u00edv\u00e1 ani tak v titulku o \u00fadajn\u00e9m \u201eomlazen\u00ed o \u0161est let\u201c jako sp\u00ed\u0161e v mo\u017enosti vyvinout v budoucnu l\u00e9ky specificky pro onemocn\u011bn\u00ed a procesy st\u00e1rnut\u00ed sou\u010dasn\u011b.<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

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L\u00e9k vyvinut\u00fd s vyu\u017eit\u00edm um\u011bl\u00e9 inteligence by mohl nejen l\u00e9\u010dit z\u00e1va\u017en\u00e9 onemocn\u011bn\u00ed plic, ale tak\u00e9…<\/p>\n","protected":false},"author":2,"featured_media":72622,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[3101,1020,11613,1561],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/115546"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=115546"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/115546\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/72622"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=115546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=115546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=115546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}