{"id":115258,"date":"2026-09-08T00:12:08","date_gmt":"2026-09-07T22:12:08","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=115258"},"modified":"2026-09-07T11:47:42","modified_gmt":"2026-09-07T09:47:42","slug":"lipidove-nanocastice-pouzivane-v-mrna-vakcinach-podporuji-nadorove-metastazy-v-mysim-modelu","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/09\/08\/lipidove-nanocastice-pouzivane-v-mrna-vakcinach-podporuji-nadorove-metastazy-v-mysim-modelu\/","title":{"rendered":"Lipidov\u00e9 nano\u010d\u00e1stice pou\u017e\u00edvan\u00e9 v mRNA vakc\u00edn\u00e1ch podporuj\u00ed n\u00e1dorov\u00e9 metast\u00e1zy v my\u0161\u00edm modelu"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Od \u0161irok\u00e9ho zaveden\u00ed mRNA vakc\u00edn je tato technologie prezentov\u00e1na jako jedna z velk\u00fdch l\u00e9ka\u0159sk\u00fdch inovac\u00ed na\u0161\u00ed doby. Mnohem m\u00e9n\u011b pozornosti ve\u0159ejnosti bylo v\u011bnov\u00e1no lipidov\u00fdm nano\u010d\u00e1stic\u00edm (LNP) pot\u0159ebn\u00fdm k transportu citliv\u00e9 mRNA do bun\u011bk. Tyto \u010d\u00e1stice v\u0161ak v \u017e\u00e1dn\u00e9m p\u0159\u00edpad\u011b nejsou pouze pasivn\u00edm obalem. Ji\u017e l\u00e9ta je zn\u00e1mo, \u017ee samotn\u00e9 LNP mohou spou\u0161t\u011bt imunologick\u00e9 a z\u00e1n\u011btliv\u00e9 reakce. Studie\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1748013226000666?via%3Dihub\" target=\"_blank\" rel=\"noopener\" data-type=\"link\" data-id=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1748013226000666?via%3Dihub\">publikovan\u00e1<\/a>\u00a0v roce 2026 v \u010dasopise\u00a0<\/span><em><span dir=\"auto\">Nano Today<\/span><\/em><span dir=\"auto\">\u00a0nyn\u00ed nastoluje obzvl\u00e1\u0161t\u011b nal\u00e9havou ot\u00e1zku:\u00a0<strong>Mohly by n\u011bkter\u00e9 z t\u011bchto nosi\u010dov\u00fdch syst\u00e9m\u016f za specifick\u00fdch podm\u00ednek dokonce podporovat \u0161\u00ed\u0159en\u00ed st\u00e1vaj\u00edc\u00edch n\u00e1dorov\u00fdch bun\u011bk?<\/strong><\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V\u00fdsledky na my\u0161\u00edm modelu jsou jist\u011b natolik\u00a0<\/span><strong><span dir=\"auto\">alarmuj\u00edc\u00ed<\/span><\/strong><span dir=\"auto\">\u00a0, \u017ee si zaslou\u017e\u00ed bli\u017e\u0161\u00ed zkoum\u00e1n\u00ed. V\u011bdci nejen uv\u00e1d\u011bj\u00ed zv\u00fd\u0161en\u00e9 metast\u00e1zy, ale tak\u00e9 popisuj\u00ed specifick\u00fd biologick\u00fd mechanismus, kter\u00fd u testovan\u00fdch zv\u00ed\u0159at vedl od po\u0161kozen\u00ed svalov\u00fdch bun\u011bk p\u0159es syst\u00e9movou z\u00e1n\u011btlivou reakci a\u017e k tvorb\u011b prost\u0159ed\u00ed podporuj\u00edc\u00edho metast\u00e1zy v plic\u00edch. Studie v\u00fdslovn\u011b nedokazuje, \u017ee mRNA vakc\u00edny zp\u016fsobuj\u00ed rakovinu nebo podporuj\u00ed metast\u00e1zy u lid\u00ed.\u00a0<\/span><strong><span dir=\"auto\">Zpochyb\u0148uje v\u0161ak p\u0159edstavu, \u017ee pou\u017eit\u00e9 lipidov\u00e9 nano\u010d\u00e1stice jsou pouze biologicky ne\u0161kodn\u00fdmi nosi\u010di.<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">Auto\u0159i p\u00ed\u0161\u00ed:<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eUkazujeme zde, \u017ee pod\u00e1v\u00e1n\u00ed \u010d\u00e1stic LNP podporuje n\u00e1dorov\u00e9 metast\u00e1zy spu\u0161t\u011bn\u00edm syst\u00e9mov\u00e9 z\u00e1n\u011btliv\u00e9 reakce. V my\u0161\u00edch modelech vedla injekce \u010d\u00e1stic LNP k akutn\u00ed akumulaci neutrofil\u016f v plic\u00edch, zp\u016fsoben\u00e9 uvoln\u011bn\u00edm mitochondri\u00e1ln\u00ed DNA (mtDNA) z nekrotick\u00fdch svalov\u00fdch bun\u011bk v m\u00edst\u011b injekce.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">V t\u00e9to studii jsme zjistili, \u017ee intramuskul\u00e1rn\u00ed injekce \u010d\u00e1stic LNP vedla k lok\u00e1ln\u00ed nekr\u00f3ze svalov\u00fdch bun\u011bk, \u010d\u00edm\u017e se uvolnila mitochondri\u00e1ln\u00ed DNA (mtDNA) do krevn\u00edho ob\u011bhu jako molekul\u00e1rn\u00ed vzorec souvisej\u00edc\u00ed s po\u0161kozen\u00edm (DAMP). Cirkuluj\u00edc\u00ed mtDNA n\u00e1sledn\u011b aktivovala neutrofily prost\u0159ednictv\u00edm sign\u00e1ln\u00edch drah TLR9-MyD88 a cGAS-STING [31], [32], co\u017e vedlo k jejich akumulaci v plic\u00edch a tvorb\u011b prost\u0159ed\u00ed podporuj\u00edc\u00edho metast\u00e1zy prost\u0159ednictv\u00edm tvorby extracelul\u00e1rn\u00edch past\u00ed (NET) neutrofil\u016f. D\u016fle\u017eit\u00e9 je, \u017ee genetick\u00e1 eliminace kl\u00ed\u010dov\u00fdch sign\u00e1ln\u00edch molekul (Tlr9\u207b\/\u207b, MyD88\u207b\/\u207b, Sting\u207b\/\u207b) tento \u00fa\u010dinek zvr\u00e1tila, co\u017e potvrdilo kauz\u00e1ln\u00ed roli z\u00e1n\u011btu indukovan\u00e9ho LNP v metast\u00e1z\u00e1ch. Zat\u00edmco p\u0159edchoz\u00ed zpr\u00e1vy zd\u016fraz\u0148ovaly imunostimula\u010dn\u00ed vlastnosti \u010d\u00e1stic LNP, na\u0161e v\u00fdsledky nazna\u010duj\u00ed, \u017ee jejich \u00fa\u010dinky p\u0159esahuj\u00ed r\u00e1mec konven\u010dn\u00edch adjuvanci\u00ed vakc\u00edn a mohou potenci\u00e1ln\u011b ovlivnit progresi rakoviny. Nepova\u017eujeme to za \u201evedlej\u0161\u00ed \u00fa\u010dinek\u201c, ale sp\u00ed\u0161e za kritick\u00fd aspekt v\u00fdvoje a aplikace mRNA-LNP l\u00e9\u010div.<\/span><\/em><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h4 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1748013226000666?via%3Dihub\" target=\"_blank\" rel=\"nofollow noopener\"><span dir=\"auto\">Zdroj<\/span><\/a><\/span><\/h4>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Od \u0161irok\u00e9ho zaveden\u00ed mRNA vakc\u00edn je tato technologie prezentov\u00e1na jako jedna z velk\u00fdch l\u00e9ka\u0159sk\u00fdch inovac\u00ed&#8230;<\/p>\n","protected":false},"author":2,"featured_media":115259,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[694,1366,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/115258"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=115258"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/115258\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/115259"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=115258"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=115258"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=115258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}