{"id":113752,"date":"2026-08-21T00:39:31","date_gmt":"2026-08-20T22:39:31","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=113752"},"modified":"2026-08-20T18:46:09","modified_gmt":"2026-08-20T16:46:09","slug":"smrtici-retezova-reakce-devatenactileta-divka-zemrela-po-injekci-na-hubnuti","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/08\/21\/smrtici-retezova-reakce-devatenactileta-divka-zemrela-po-injekci-na-hubnuti\/","title":{"rendered":"Smrt\u00edc\u00ed \u0159et\u011bzov\u00e1 reakce: Devaten\u00e1ctilet\u00e1 d\u00edvka zem\u0159ela po injekci na hubnut\u00ed"},"content":{"rendered":"
<\/div>\n

Devaten\u00e1ctilet\u00e1 studentka u\u017e\u00edvala tirzepatid na hubnut\u00ed, st\u011b\u017eovala si na nevolnost a zvracen\u00ed a o n\u011bkolik hodin pozd\u011bji byla nalezena mrtv\u00e1 ve sv\u00e9 koupeln\u011b. Josephine Nasr nebyla ob\u00e9zn\u00ed a krom\u011b d\u0159\u00edve nezji\u0161t\u011bn\u00e9 srde\u010dn\u00ed vady byla pova\u017eov\u00e1na za zdravou. Vy\u0161et\u0159ov\u00e1n\u00ed v\u00fdslovn\u011b uv\u00e1d\u00ed p\u0159edepsan\u00e9 l\u00e9ky jako sou\u010d\u00e1st \u0159et\u011bzov\u00e9 reakce, kter\u00e1 vyvrcholila smrtelnou srde\u010dn\u00ed arytmi\u00ed. P\u0159\u00edpad se shoduje s multimiliardov\u00fdm boomem l\u00e9ku GLP-1, kter\u00fd se ji\u017e d\u00e1vno roz\u0161\u00ed\u0159il na d\u011bti a dosp\u00edvaj\u00edc\u00ed.<\/span><\/strong><\/p>\n

Podle zpr\u00e1v britsk\u00fdch m\u00e9di\u00ed<\/span><\/a>\u00a0se Josephine Nasrov\u00e1\u00a0jen o n\u011bkolik dn\u00ed d\u0159\u00edve vr\u00e1tila do Lond\u00fdna ze sv\u00e9ho domova v Kalifornii, kde studovala pr\u00e1va na University of East London. Ve\u010der 23. z\u00e1\u0159\u00ed 2025, kolem 20:30, telefonovala rodi\u010d\u016fm a sest\u0159e. Uvedla, \u017ee se j\u00ed d\u011bl\u00e1 nevolno a zvrac\u00ed. Jej\u00ed sestra, kter\u00e1 se ob\u00e1vala dehydratace, za\u0159\u00eddila, aby devaten\u00e1ctilet\u00e9 d\u00edvce sestra podala intraven\u00f3zn\u00ed injekci. Kdy\u017e Nasrov\u00e1 n\u00e1sledn\u011b p\u0159estala zvedat telefon, rodina kontaktovala univerzitn\u00ed ostrahu. N\u011bco m\u00e1lo p\u0159es dv\u011b hodiny po posledn\u00edm hovoru na\u0161li zam\u011bstnanci studentku bez pov\u0161imnut\u00ed na podlaze koupelny. Vedle n\u00ed le\u017eela pr\u00e1zdn\u00e1 lahvi\u010dka s tirzepatidem. Z\u00e1chran\u00e1\u0159i ji mohli pouze konstatovat jako mrtvou.<\/span><\/p>\n

Od zvracen\u00ed k fat\u00e1ln\u00ed srde\u010dn\u00ed arytmii<\/span><\/h3>\n

Nasr j\u00ed v l\u00e9t\u011b 2025 v Kalifornii p\u0159edepsal tirzepatid. L\u00e9k prod\u00e1v\u00e1 spole\u010dnost Eli Lilly pod n\u00e1zvem Zepbound na hubnut\u00ed a pod n\u00e1zvem Mounjaro na l\u00e9\u010dbu diabetu 2. typu. Podle soudn\u00edho vy\u0161et\u0159ov\u00e1n\u00ed se Nas\u0159ino BMI pohybovalo pouze v rozmez\u00ed nadv\u00e1hy, nikoli obezity.\u00a0<\/span>V USA<\/span><\/a>\u00a0je Zepbound schv\u00e1len pro pacienty s nadv\u00e1hou a BMI 27 nebo vy\u0161\u0161\u00edm, pouze pokud maj\u00ed alespo\u0148 jednu komorbiditu souvisej\u00edc\u00ed s hmotnost\u00ed. Dosud zve\u0159ejn\u011bn\u00e9 dokumenty \u017e\u00e1dnou takovou komorbiditu v Nas\u0159in\u011b p\u0159\u00edpad\u011b neuv\u00e1d\u011bj\u00ed.<\/span><\/p>\n

B\u011bhem pitvy patolog Alan Bates objevil vrozen\u00fd myokardi\u00e1ln\u00ed m\u016fstek, kdy segment koron\u00e1rn\u00ed tepny proch\u00e1z\u00ed tk\u00e1n\u00ed srde\u010dn\u00edho svalu. Bates u soudu vysv\u011btlil, \u017ee tirzepatid m\u016f\u017ee zp\u016fsobit nevolnost a zvracen\u00ed. Siln\u00e9 zvracen\u00ed m\u016f\u017ee zp\u016fsobit pokles hladiny cukru v krvi a naru\u0161en\u00ed elektrolytov\u00e9 rovnov\u00e1hy; takov\u00fd posun m\u016f\u017ee n\u00e1sledn\u011b spustit srde\u010dn\u00ed arytmie. Podle patologa Nasrova nezji\u0161t\u011bn\u00e1 srde\u010dn\u00ed abnormalita zv\u00fd\u0161ila riziko. Bates popsal devaten\u00e1ctiletou d\u00edvku jako \u201ejinak zdravou mladou \u017eenu\u201c.<\/span><\/p>\n

Soudn\u00ed rozhodnut\u00ed o jej\u00ed smrti jasn\u011b sleduje \u0159et\u011bzec ud\u00e1lost\u00ed: Nasr zem\u0159ela na smrtelnou srde\u010dn\u00ed arytmii, kter\u00e1 byla d\u016fsledkem interakce jej\u00edho d\u0159\u00edve nediagnostikovan\u00e9ho srde\u010dn\u00edho onemocn\u011bn\u00ed s elektrolytovou nerovnov\u00e1hou. Tato nerovnov\u00e1ha vznikla po zvracen\u00ed zp\u016fsoben\u00e9m hypoglyk\u00e9mi\u00ed \u2013 a hypoglyk\u00e9mie je v\u00fdslovn\u011b uv\u00e1d\u011bna jako vedlej\u0161\u00ed \u00fa\u010dinek p\u0159edepsan\u00e9ho tirzepatidu. Soudn\u00ed vy\u0161et\u0159ov\u00e1n\u00ed proto uv\u00e1d\u00ed tento l\u00e9k jako faktor p\u0159isp\u00edvaj\u00edc\u00ed ke zji\u0161t\u011bn\u00e9 p\u0159\u00ed\u010din\u011b smrti.<\/span><\/p>\n

V\u00edce ne\u017e 200 britsk\u00fdch \u00famrt\u00ed<\/span><\/h3>\n

Vzhledem k tomu, \u017ee ve Spojen\u00e9m kr\u00e1lovstv\u00ed st\u00e1le p\u0159ib\u00fdv\u00e1 \u00fadaj\u016f o bezpe\u010dnosti popul\u00e1rn\u00edch injekc\u00ed na hubnut\u00ed, tento p\u0159\u00edpad p\u0159id\u00e1v\u00e1 na seznam dal\u0161\u00ed \u00famrt\u00ed. Na za\u010d\u00e1tku srpna zaznamenala Agentura pro regulaci l\u00e9\u010div a zdravotnick\u00fdch prost\u0159edk\u016f (MHRA)\u00a0<\/span>120<\/span><\/a>\u00a0podez\u0159en\u00ed na ne\u017e\u00e1douc\u00ed \u00fa\u010dinky tirzepatidu, 59 na semaglutid a 37 na liraglutid \u2013 celkem 216. Krom\u011b toho je hl\u00e1\u0161eno v\u00edce ne\u017e 150 000 podez\u0159en\u00ed na ne\u017e\u00e1douc\u00ed \u00fa\u010dinky. \u00dadaje ze \u017dlut\u00e9 karty zahrnuj\u00ed hl\u00e1\u0161en\u00e1 podez\u0159en\u00ed na ne\u017e\u00e1douc\u00ed \u00fa\u010dinky; v p\u0159\u00edpad\u011b Nasr existuje tak\u00e9 konkr\u00e9tn\u00ed soudn\u00ed rozhodnut\u00ed o p\u0159\u00ed\u010din\u011b \u00famrt\u00ed.<\/span><\/p>\n

Britsk\u00e1 Agentura pro regulaci l\u00e9\u010div a zdravotnick\u00fdch prost\u0159edk\u016f (MHRA)\u00a0<\/span>zp\u0159\u00edsnila<\/span><\/a>\u00a0za\u010d\u00e1tkem roku 2026 sv\u00e1 varov\u00e1n\u00ed pro p\u0159\u00edpravky s certifikac\u00ed GLP-1 a kombinovan\u00e9 p\u0159\u00edpravky s certifikac\u00ed GLP-1\/GIP. Mezi lety 2007 a \u0159\u00edjnem 2025 obdr\u017eela MHRA 1 296 hl\u00e1\u0161en\u00ed o pankreatitid\u011b spojen\u00e9 s t\u011bmito l\u00e9ky, v\u010detn\u011b 19 fat\u00e1ln\u00edch p\u0159\u00edpad\u016f a 24 p\u0159\u00edpad\u016f nekrotizuj\u00edc\u00ed pankreatitidy. Informace o p\u0159\u00edpravku byly n\u00e1sledn\u011b aktualizov\u00e1ny o explicitn\u011bj\u0161\u00ed varov\u00e1n\u00ed t\u00fdkaj\u00edc\u00ed se z\u00e1va\u017en\u00fdch, nekrotizuj\u00edc\u00edch a fat\u00e1ln\u00edch n\u00e1sledk\u016f.<\/span><\/p>\n

Boom GLP-1 se dost\u00e1v\u00e1 k mlad\u00fdm lidem<\/span><\/h3>\n

Z\u00e1rove\u0148 prudce roste po\u010det l\u00e9k\u016f p\u0159edepsan\u00fdch mlad\u00fdmi lidmi. Studie\u00a0<\/span>\u201eDispensing of Glucagon-Like Peptide-1 Receptor Agonists to Adolescents and Young Adults, 2020\u20132023\u201c (V\u00fddej agonist\u016f receptoru glukagonov\u00e9ho peptidu-1 dosp\u00edvaj\u00edc\u00edm a mlad\u00fdm dosp\u011bl\u00fdm, 2020\u20132023),<\/span><\/a>\u00a0publikovan\u00e1 v \u010dasopise JAMA v roce 2024, analyzovala data z p\u0159ibli\u017en\u011b 94 procent americk\u00fdch l\u00e9k\u00e1ren. Mezi lety 2020 a 2023 se m\u011bs\u00ed\u010dn\u00ed po\u010det 12 a\u017e 25let\u00fdch, kte\u0159\u00ed obdr\u017eeli recept na GLP-1, zv\u00fd\u0161il z 8 722 na 60 567 \u2013 co\u017e p\u0159edstavuje n\u00e1r\u016fst o 594,4 procenta. Jen v roce 2023 dostalo takov\u00fd l\u00e9k 30 947 dosp\u00edvaj\u00edc\u00edch ve v\u011bku 12 a\u017e 17 let. V receptech pro dosp\u00edvaj\u00edc\u00ed se objevil i tirzepatid, a\u010dkoli v t\u00e9 dob\u011b byl tento l\u00e9k schv\u00e1len pouze pro dosp\u011bl\u00e9.<\/span><\/p>\n

Americk\u00e1 akademie pediatrie (AAP) provedla na za\u010d\u00e1tku roku 2023 rozhoduj\u00edc\u00ed zm\u011bnu v politice. Jej\u00ed\u00a0<\/span>sm\u011brnice<\/span><\/a>\u00a0doporu\u010duj\u00ed, aby l\u00e9ka\u0159i ob\u00e9zn\u00edm dosp\u00edvaj\u00edc\u00edm ve v\u011bku 12 let a star\u0161\u00edm nab\u00edzeli l\u00e9ky na hubnut\u00ed, a to krom\u011b \u00faprav \u017eivotn\u00edho stylu. U ob\u00e9zn\u00edch d\u011bt\u00ed ve v\u011bku od osmi do jeden\u00e1cti let AAP zva\u017euje jako mo\u017enou l\u00e9\u010debnou mo\u017enost i farmakoterapii. U t\u011b\u017ece ob\u00e9zn\u00edch dosp\u00edvaj\u00edc\u00edch ve v\u011bku 13 let a star\u0161\u00edch doporu\u010duje odesl\u00e1n\u00ed pacienta k vy\u0161et\u0159en\u00ed metabolick\u00e9 nebo bariatrick\u00e9 chirurgie.<\/span><\/p>\n

Farmaceutick\u00e9 miliony a tajn\u00e9 konexie<\/span><\/h3>\n

Zji\u0161t\u011bn\u00ed studie z roku 2025 o v\u00fdvoji t\u011bchto pokyn\u016f jsou proto obzvl\u00e1\u0161t\u011b d\u016fle\u017eit\u00e1. \u010cl\u00e1nek publikovan\u00fd v BMJ s n\u00e1zvem\u00a0<\/span>\u201eCaution is prescripted for American Academy of Paediatrics‘ guidelines on weight loss medications for childhood obesity\u201c (Sm\u011brnice Americk\u00e9 akademie pediatrie k l\u00e9k\u016fm na hubnut\u00ed u d\u011bt\u00ed s obezitou je t\u0159eba db\u00e1t opatrnosti)<\/span><\/a>\u00a0dokumentoval rozs\u00e1hl\u00e9 finan\u010dn\u00ed vazby mezi AAP (nebo t\u011bmi, kte\u0159\u00ed se pod\u00edleli na procesu tvorby pokyn\u016f) a v\u00fdrobci l\u00e9k\u016f na obezitu. Podle studie AAP od roku 2012 obdr\u017eela od farmaceutick\u00fdch spole\u010dnost\u00ed, kter\u00e9 tyto l\u00e9ky vyv\u00edjej\u00ed \u2013 v\u010detn\u011b spole\u010dnost\u00ed Novo Nordisk a Eli Lilly \u2013 nejm\u00e9n\u011b 1,9 a\u017e 2,6 milionu dolar\u016f.<\/span><\/p>\n

Nejm\u00e9n\u011b 22 procent vy\u0161et\u0159ovan\u00fdch \u00fa\u0159edn\u00edk\u016f AAP na n\u00e1rodn\u00ed \u00farovni obdr\u017eelo od t\u011bchto spole\u010dnost\u00ed osobn\u00ed platby. Mezi lety 2017 a 2023 tyto platby dos\u00e1hly celkov\u00e9 v\u00fd\u0161e v\u00edce ne\u017e 293 000 dolar\u016f. Situace je je\u0161t\u011b v\u00fdrazn\u011bj\u0161\u00ed v pracovn\u00ed skupin\u011b, kter\u00e1 vypracovala sm\u011brnice pro obezitu: 37 procent jej\u00edch \u010dlen\u016f m\u011blo finan\u010dn\u00ed vazby na p\u0159\u00edslu\u0161n\u00e9 farmaceutick\u00e9 spole\u010dnosti. Podle v\u00fdzkumn\u00edk\u016f tyto vazby nebyly v ofici\u00e1ln\u00edch publikac\u00edch AAP zve\u0159ejn\u011bny. Nav\u00edc v dob\u011b vyd\u00e1n\u00ed sm\u011brnic nebyla k dispozici \u017e\u00e1dn\u00e1 klinick\u00e1 studie, kter\u00e1 by prok\u00e1zala bezpe\u010dnost a \u00fa\u010dinnost l\u00e9ku u d\u011bt\u00ed mlad\u0161\u00edch dvan\u00e1cti let v t\u00e9to v\u011bkov\u00e9 skupin\u011b.<\/span><\/p>\n

FDA napomenula spole\u010dnost Novo Nordisk za hl\u00e1\u0161en\u00ed ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f<\/span><\/h3>\n

V\u00fdznamn\u00e9 probl\u00e9my se objevuj\u00ed i \u200b\u200bv samotn\u00e9m procesu monitorov\u00e1n\u00ed bezpe\u010dnosti. Dne 5. b\u0159ezna 2026 americk\u00fd \u00da\u0159ad pro kontrolu potravin a l\u00e9\u010div (FDA) zjistil, \u017ee se spole\u010dnost Novo Nordisk dopustila \u201e\u00a0<\/span>z\u00e1va\u017en\u00e9ho poru\u0161en\u00ed<\/span><\/a>\u00a0\u201c sv\u00fdch p\u0159edpis\u016f pro hl\u00e1\u0161en\u00ed ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f l\u00e9\u010div. Intern\u00ed pravidla spole\u010dnosti umo\u017e\u0148ovala spole\u010dnostem vylou\u010dit z hl\u00e1\u0161en\u00ed z\u00e1va\u017en\u00e9 a neo\u010dek\u00e1van\u00e9 p\u0159\u00edpady, pokud hl\u00e1s\u00edc\u00ed strana nem\u011bla podez\u0159en\u00ed na souvislost s l\u00e9\u010divem. Podle americk\u00e9ho pr\u00e1va mus\u00ed b\u00fdt takov\u00e9 ud\u00e1losti zaznamen\u00e1ny bez ohledu na toto posouzen\u00ed a nahl\u00e1\u0161eny FDA do 15 dn\u016f, pokud jsou spln\u011bna krit\u00e9ria pro hl\u00e1\u0161en\u00ed.<\/span><\/p>\n

Agentura uv\u00e1d\u00ed n\u011bkolik konkr\u00e9tn\u00edch p\u0159\u00edklad\u016f. Spole\u010dnost Novo Nordisk zru\u0161ila p\u0159\u00edpad \u00famrt\u00ed mu\u017ee l\u00e9\u010den\u00e9ho semaglutidem, \u00fadajn\u011b z d\u016fvodu nedostate\u010dn\u00e9 identifikace pacienta; audito\u0159i FDA pozd\u011bji zjistili chyb\u011bj\u00edc\u00ed informace v p\u016fvodn\u00edch dokumentech. Spole\u010dnost uzav\u0159ela dal\u0161\u00ed p\u0159\u00edpad \u00famrt\u00ed souvisej\u00edc\u00ed se semaglutidem, ani\u017e by provedla po\u017eadovan\u00e9 n\u00e1sledn\u00e9 kroky. V jin\u00e9m p\u0159\u00edpad\u011b l\u00e9ka\u0159 ozn\u00e1mil, \u017ee pacient b\u011bhem u\u017e\u00edv\u00e1n\u00ed semaglutidu upadl do deprese a sp\u00e1chal sebevra\u017edu. Podle FDA spole\u010dnost Novo Nordisk nezdokumentovala \u017e\u00e1dn\u00fd pokus o z\u00edsk\u00e1n\u00ed dal\u0161\u00edch informac\u00ed. Spole\u010dnost tento p\u0159\u00edpad agentu\u0159e ani nenahl\u00e1sila v den vyd\u00e1n\u00ed varovn\u00e9ho dopisu.<\/span><\/p>\n

Cena boomu s injek\u010dn\u00ed dietou<\/span><\/h3>\n

Josephine Nasr bylo 19 let a nebyla ob\u00e9zn\u00ed. Dostala vysoce \u00fa\u010dinn\u00fd l\u00e9k na hubnut\u00ed, u kter\u00e9ho se u n\u00ed rozvinuly zn\u00e1m\u00e9 gastrointestin\u00e1ln\u00ed ne\u017e\u00e1douc\u00ed \u00fa\u010dinky a tent\u00fd\u017e ve\u010der zem\u0159ela. Vy\u0161et\u0159ov\u00e1n\u00ed rekonstruovalo \u0159et\u011bzec ud\u00e1lost\u00ed od tirzepatidu p\u0159es zvracen\u00ed, hypoglyk\u00e9mii a elektrolytovou nerovnov\u00e1hu a\u017e po fat\u00e1ln\u00ed srde\u010dn\u00ed arytmii, zhor\u0161enou srde\u010dn\u00ed chorobou, o kter\u00e9 mlad\u00e1 \u017eena nev\u011bd\u011bla.<\/span><\/p>\n

Z\u00e1rove\u0148 se tyto l\u00e9ky dost\u00e1vaj\u00ed ke st\u00e1le mlad\u0161\u00edm pacient\u016fm, zat\u00edmco farmaceutick\u00e9 spole\u010dnosti na tomto byznysu vyd\u011bl\u00e1vaj\u00ed miliardy. L\u00e9ka\u0159sk\u00e9 asociace ji\u017e tyto l\u00e9ky doporu\u010duj\u00ed pro ob\u00e9zn\u00ed d\u011bti, p\u0159esto\u017ee za t\u011bmito pokyny jsou z\u0159ejm\u00e9 finan\u010dn\u00ed vazby na v\u00fdrobce. A zat\u00edmco trh roste, FDA mus\u00ed pok\u00e1rat jednoho z nejv\u011bt\u0161\u00edch producent\u016f GLP-1 za z\u00e1va\u017en\u00e9 nedostatky ve shroma\u017e\u010fov\u00e1n\u00ed a hl\u00e1\u0161en\u00ed ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f. Smrt Josephine Nasrov\u00e9 ukazuje, jak rychle m\u016f\u017ee zd\u00e1nliv\u011b jednoduch\u00e1 injekce na hubnut\u00ed spustit smrt\u00edc\u00ed \u0159et\u011bzovou reakci.<\/span><\/p>\n

\"\"<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Devaten\u00e1ctilet\u00e1 studentka u\u017e\u00edvala tirzepatid na hubnut\u00ed, st\u011b\u017eovala si na nevolnost a zvracen\u00ed a o n\u011bkolik…<\/p>\n","protected":false},"author":2,"featured_media":113753,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[11457,3373,523,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/113752"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=113752"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/113752\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/113753"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=113752"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=113752"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=113752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}