{"id":112400,"date":"2026-08-05T00:22:01","date_gmt":"2026-08-04T22:22:01","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=112400"},"modified":"2026-08-04T08:08:14","modified_gmt":"2026-08-04T06:08:14","slug":"americka-vlada-financuje-vyzkum-koronaviru-a-patenty-ralpha-barice-od-roku-1984","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/08\/05\/americka-vlada-financuje-vyzkum-koronaviru-a-patenty-ralpha-barice-od-roku-1984\/","title":{"rendered":"Americk\u00e1 vl\u00e1da financuje v\u00fdzkum koronaviru a patenty Ralpha Barice od roku 1984"},"content":{"rendered":"
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Chronologick\u00fd seznam financov\u00e1n\u00ed, publikac\u00ed a patent\u016f NIH dokumentuje v\u00edce ne\u017e \u010dty\u0159i desetilet\u00ed nep\u0159etr\u017eit\u00fdch vl\u00e1dn\u00edch investic do dal\u0161\u00edho v\u00fdvoje n\u00e1stroj\u016f Baric pro koronavirus.<\/span><\/strong><\/p>\n

Vl\u00e1da USA prost\u0159ednictv\u00edm N\u00e1rodn\u00edch institut\u016f zdrav\u00ed (NIH) \u2013 p\u0159edev\u0161\u00edm prost\u0159ednictv\u00edm N\u00e1rodn\u00edho institutu pro alergie a infek\u010dn\u00ed nemoci (NIAID) \u2013 financuje v\u00fdzkum koronaviru, kter\u00fd provedl Ralph Baric, ji\u017e v\u00edce ne\u017e \u010dty\u0159i desetilet\u00ed, od jeho nejran\u011bj\u0161\u00edch publikovan\u00fdch prac\u00ed v oblasti molekul\u00e1rn\u00ed biologie a\u017e po desetilet\u00ed st\u00e1le sofistikovan\u011bj\u0161\u00edch laboratorn\u00edch technologi\u00ed, experiment\u00e1ln\u00edch syst\u00e9m\u016f, studi\u00ed mutac\u00ed a patentovan\u00fdch vyn\u00e1lez\u016f.<\/span><\/p>\n

Ve\u0159ejn\u00e1 diskuse o Bari\u0107ov\u011b pr\u00e1ci t\u00fdkaj\u00edc\u00ed se koronaviru \u010dasto za\u010d\u00edn\u00e1 n\u00e1vrhem DEFUSE z roku 2018 nebo jeho spoluprac\u00ed v letech bezprost\u0159edn\u011b p\u0159edch\u00e1zej\u00edc\u00edch COVID-19.<\/span><\/p>\n

Z\u00e1znamy o feder\u00e1ln\u00edm financov\u00e1n\u00ed v\u0161ak vypov\u00eddaj\u00ed mnohem del\u0161\u00ed p\u0159\u00edb\u011bh.<\/span><\/p>\n

V dob\u011b psan\u00ed knihy DEFUSE ji\u017e NIH financoval postupn\u00fd rozvoj Baricova v\u00fdzkumu koronaviru po dobu v\u00edce ne\u017e t\u0159\u00ed desetilet\u00ed.<\/span><\/p>\n

Nejstar\u0161\u00ed publikovan\u00e9 d\u016fkazy identifikovan\u00e9 v t\u00e9to studii poch\u00e1zej\u00ed z roku 1984, kdy Baric spoluautorem napsal kapitolu financovanou NIH o molekul\u00e1rn\u00edch mechanismech synt\u00e9zy koronavirov\u00e9 RNA, kter\u00e1 byla podpo\u0159ena grantem NIH AI19244.<\/span><\/p>\n

V n\u00e1sleduj\u00edc\u00edch desetilet\u00edch podporovaly po sob\u011b jdouc\u00ed granty NIH v\u00fdvoj laboratorn\u00edch technik pro koronaviry, platforem reverzn\u00ed genetiky, syst\u00e9m\u016f mutageneze, infek\u010dn\u00edch klon\u016f, technologi\u00ed produkce spike protein\u016f, diagnostiky, model\u016f vstupu vir\u016f, vir\u016f adaptovan\u00fdch na my\u0161i, technologi\u00ed vakc\u00edn a vl\u00e1dou financovan\u00fdch patentovan\u00fdch vyn\u00e1lez\u016f.<\/span><\/p>\n

M\u00edsto financov\u00e1n\u00ed izolovan\u00fdch experiment\u016f NIH podporoval neust\u00e1l\u00fd pokrok ve v\u00fdzkumu koronaviru, p\u0159i\u010dem\u017e ka\u017ed\u00e1 generace v\u00fdzkumn\u00edk\u016f zav\u00e1d\u011bla nov\u00e9 laboratorn\u00ed kapacity, kter\u00e9 roz\u0161i\u0159ovaly mo\u017enosti, kter\u00e9 v\u011bdci podle sv\u00fdch slov mohou s genomy koronaviru vyu\u017e\u00edt.<\/span><\/p>\n

Baricovy publikace financovan\u00e9 NIH opakovan\u011b zav\u00e1d\u011bly nov\u00e9 metody a technologie, zat\u00edmco n\u00e1sledn\u00e9 patentov\u00e9 p\u0159ihl\u00e1\u0161ky potvrdily vl\u00e1dn\u00ed podporu mnoha v\u00fdsledn\u00fdch vyn\u00e1lez\u016f.<\/span><\/p>\n

Chronologicky vzato dokumentuj\u00ed financov\u00e1n\u00ed, publikace a patenty v\u00edce ne\u017e jen historii financov\u00e1n\u00ed.<\/span><\/p>\n

Dokumentuj\u00ed postupn\u00fd v\u00fdvoj st\u00e1le sofistikovan\u011bj\u0161\u00ed sady n\u00e1stroj\u016f pro v\u00fdzkum koronaviru.<\/span><\/p>\n

Kdy\u017e se v roce 2019 objevil SARS-CoV-2, ve\u0159ejn\u011b dostupn\u00e9 dokumenty ukazovaly, \u017ee NIH financoval v\u00fdvoj mnoha experiment\u00e1ln\u00edch metod, laboratorn\u00edch technologi\u00ed a v\u00fdzkumn\u00fdch platforem dostupn\u00fdch pro v\u00fdzkum koronaviru b\u011bhem \u00e9ry COVID-19 po v\u00edce ne\u017e t\u0159i desetilet\u00ed.<\/span><\/p>\n

1984: Financov\u00e1n\u00ed AI19244<\/span><\/strong><\/h2>\n

V roce 1984 publikoval Baric, tehdej\u0161\u00ed\u00a0<\/span>postdoktorandsk\u00fd v\u00fdzkumn\u00edk<\/span><\/a>\u00a0na University of Southern California, studii o koronavirech financovanou NIH.<\/span><\/p>\n

V\u00a0<\/span>\u010dl\u00e1nku \u201eStudie o mechanismu synt\u00e9zy RNA my\u0161\u00edho koronaviru\u201c<\/span><\/a><\/em>\u00a0se Baric a jeho kolegov\u00e9 pokusili vysv\u011btlit, jak koronaviry \u00fadajn\u011b replikuj\u00ed sv\u016fj genom a produkuj\u00ed svou RNA, a navrhli nov\u00e9 mechanistick\u00e9 modely pro transkripci a replikaci koronavir\u016f.<\/span><\/p>\n

Kapitola ocenila podporu poskytnutou grantem NIH AI19244, kter\u00fd dokazuje vl\u00e1dn\u00ed financov\u00e1n\u00ed Bari\u0107ova v\u00fdzkumu koronaviru roky p\u0159edt\u00edm, ne\u017e si zalo\u017eil vlastn\u00ed nez\u00e1vislou laborato\u0159.<\/span><\/p>\n

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1986\u20132007: Financov\u00e1n\u00ed AI023946<\/span><\/strong><\/h2>\n

V roce 1986 N\u00e1rodn\u00ed institut pro alergie a infek\u010dn\u00ed nemoci (NIAID) ud\u011blil Ralphu Baricovi jeho prvn\u00ed nez\u00e1visl\u00fd grant R01 s n\u00e1zvem\u00a0<\/span>AI023946<\/span><\/a>\u00a0s n\u00e1zvem \u201eV\u00fdzkum mechanismu replikace MHV\u201c.<\/span><\/p>\n

Grant financoval v\u00fdzkum toho, jak virus my\u0161\u00ed hepatitidy (MHV) \u2013 koronavirus \u2013 replikuje sv\u016fj genom a exprimuje sv\u00e9 geny, s c\u00edlem pochopit molekul\u00e1rn\u00ed mechanismy, kter\u00e9 \u0159\u00edd\u00ed replikaci koronaviru.<\/span><\/p>\n

NIAID grant pr\u016fb\u011b\u017en\u011b prodlu\u017eoval nejm\u00e9n\u011b do roku 2007, \u010d\u00edm\u017e se stal z\u00e1kladem dlouhodob\u00e9ho, vl\u00e1dou financovan\u00e9ho v\u00fdzkumn\u00e9ho programu spole\u010dnosti Baric o koronavirech.<\/span><\/p>\n

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2001\u20132004: Financov\u00e1n\u00ed projektu GM063228<\/span><\/strong><\/h2>\n

V roce 2001 schv\u00e1lil N\u00e1rodn\u00ed institut v\u0161eobecn\u00fdch l\u00e9ka\u0159sk\u00fdch v\u011bd (NIGMS), institut NIH, grantov\u00fd projekt R01\u00a0<\/span>GM063228<\/span><\/a>\u00a0pro Ralpha Barice z Univerzity Severn\u00ed Karol\u00edny s n\u00e1zvem \u201eReverzn\u00ed genetika s infek\u010dn\u00edm konstruktem koronaviru\u201c.<\/span><\/p>\n

Dotace platila do konce roku 2004.<\/span><\/p>\n

Projekt financoval v\u00fdvoj metod reverzn\u00ed genetiky pro koronaviry s vyu\u017eit\u00edm infek\u010dn\u00edch cDNA konstrukt\u016f \u2013 technologie, kter\u00e1 \u00fadajn\u011b umo\u017e\u0148uje v\u011bdc\u016fm rekonstruovat kompletn\u00ed genomy koronavir\u016f z klonovan\u00e9 DNA, zav\u00e1d\u011bt definovan\u00e9 genetick\u00e9 modifikace a z\u00edsk\u00e1vat rekombinantn\u00ed viry pro experiment\u00e1ln\u00ed studie.<\/span><\/p>\n

Grant p\u0159\u00edmo podpo\u0159il pr\u00e1ci, kter\u00e1 byla pozd\u011bji uzn\u00e1na v Baricov\u011b patentov\u00e9 rodin\u011b \u201eMetody a slo\u017een\u00ed pro infek\u010dn\u00ed cDNA koronaviru SARS\u201c.<\/span><\/p>\n

\"\"<\/figure>\n

2004\u20132008: Financov\u00e1n\u00ed AI059136<\/span><\/strong><\/h2>\n

V roce 2004, po vypuknut\u00ed epidemie SARS, schv\u00e1lil NIAID grant R01\u00a0<\/span>AI059136<\/span><\/a>\u00a0pro Ralpha Barice s n\u00e1zvem \u201eReverzn\u00ed genetika SARS\u201c.<\/span><\/p>\n

Grant financoval v\u00fdvoj a aplikaci syst\u00e9m\u016f reverzn\u00ed genetiky pro koronavirus SARS \u2013 technologie, kter\u00e1 \u00fadajn\u011b umo\u017e\u0148uje v\u011bdc\u016fm rekonstruovat infek\u010dn\u00ed viry z klonovan\u00e9 DNA, zav\u00e1d\u011bt c\u00edlen\u00e9 genetick\u00e9 modifikace a experiment\u00e1ln\u011b studovat \u00fa\u010dinky t\u011bchto zm\u011bn.<\/span><\/p>\n

NIAID ka\u017edoro\u010dn\u011b prodlu\u017eovala grant a\u017e do roku 2008, \u010d\u00edm\u017e zajistila nep\u0159etr\u017eit\u00e9 vl\u00e1dn\u00ed financov\u00e1n\u00ed Bari\u0107ova programu reverzn\u00ed genetiky SARS.<\/span><\/p>\n

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2005\u20132009: Financov\u00e1n\u00ed projektu AI059443<\/span><\/strong><\/h2>\n

V roce 2005 financovala NIAID v\u00edceprojektov\u00fd v\u00fdzkumn\u00fd program koronaviru SARS\u00a0v r\u00e1mci projektu P01\u00a0<\/span>AI059443 .<\/span><\/a><\/p>\n

Pod Bari\u0107ov\u00fdm veden\u00edm program podporoval v\u00fdvoj kandid\u00e1tn\u00edch vakc\u00edn proti SARS, klon\u016f a \u010dinidel infek\u010dn\u00edch koronavir\u016f, zv\u00ed\u0159ec\u00edch model\u016f a studi\u00ed organizace genomu, patogeneze a virov\u00e9 replikace SARS, zat\u00edmco spolupracuj\u00edc\u00ed v\u00fdzkumn\u00edci pokra\u010dovali v dal\u0161\u00edch projektech t\u00fdkaj\u00edc\u00edch se vakc\u00edn a patogeneze.<\/span><\/p>\n

Program byl financov\u00e1n do roku 2009, \u010d\u00edm\u017e v r\u00e1mci jedin\u00e9ho grantu NIAID poskytoval udr\u017eitelnou vl\u00e1dn\u00ed podporu n\u011bkolika paraleln\u00edm v\u00fdzkumn\u00fdm lini\u00edm koronaviru SARS.<\/span><\/p>\n

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2009\u20132012: Financov\u00e1n\u00ed projektu 5R01AI075297<\/span><\/strong><\/h2>\n

V roce 2009 schv\u00e1lila NIAID grantov\u00fd projekt\u00a0<\/span>R01 AI075297<\/span><\/a>\u00a0s n\u00e1zvem \u201ePatogenetick\u00e9 mechanismy SARS-CoV u st\u00e1rnouc\u00edch my\u0161\u00ed\u201c a ud\u011blila Ralphu Baricovi finan\u010dn\u00ed prost\u0159edky na zkoum\u00e1n\u00ed mechanism\u016f, kter\u00fdmi koronavirus SARS \u00fadajn\u011b zp\u016fsobuje onemocn\u011bn\u00ed u st\u00e1rnouc\u00edch my\u0161\u00edch model\u016f.<\/span><\/p>\n

Projekt se zam\u011b\u0159il na patogenezi SARS-CoV u st\u00e1rnouc\u00edch my\u0161\u00ed, co\u017e je experiment\u00e1ln\u00ed model navr\u017een\u00fd tak, aby l\u00e9pe replikoval z\u00e1va\u017en\u00e1 onemocn\u011bn\u00ed souvisej\u00edc\u00ed s v\u011bkem.<\/span><\/p>\n

Financov\u00e1n\u00ed pokra\u010dovalo nep\u0159etr\u017eit\u011b a\u017e do konce roku 2012.<\/span><\/p>\n

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2012\u20132021: Financov\u00e1n\u00ed projektu U19AI100625<\/span><\/strong><\/h2>\n

V roce 2012 NIAID ud\u011blila grant\u00a0<\/span>U19AI100625<\/span><\/a>\u00a0na multiprojektov\u00fd program zam\u011b\u0159en\u00fd na v\u00fdzkum syst\u00e9mov\u00e9 imunogenetiky infekc\u00ed SARS-CoV v \u0161ir\u0161\u00edm kontextu biologick\u00e9 obrany a nov\u011b vznikaj\u00edc\u00edch patogen\u016f.<\/span><\/p>\n

Program kombinoval studie koronavirov\u00fdch infekc\u00ed, vysoce v\u00fdkonn\u00e9 molekul\u00e1rn\u00ed profilov\u00e1n\u00ed, bioinformatiku, zv\u00ed\u0159ec\u00ed modely a genetiku my\u0161\u00ed s c\u00edlem zkoumat reakce hostitele na virov\u00e9 infekce.<\/span><\/p>\n

Grant platil do roku 2021.<\/span><\/p>\n

Od roku 2017 byla podoblast koronavir\u016f roz\u0161\u00ed\u0159ena z \u201einfekce SARS-CoV\u201c na \u201enov\u011b vznikaj\u00edc\u00ed koronavirov\u00e9 infekce v r\u00e1mci kolaborativn\u00edho k\u0159\u00ed\u017een\u00ed\u201c, zat\u00edmco celkov\u00fd program nad\u00e1le podporoval koordinovan\u00e9 studie biologick\u00e9 obrany a nov\u011b vznikaj\u00edc\u00edch patogen\u016f s vyu\u017eit\u00edm syst\u00e9mov\u00e9 imunogenetiky, bioinformatiky a geneticky diverzn\u00edch my\u0161\u00edch model\u016f.<\/span><\/p>\n

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2013\u20132017: Financov\u00e1n\u00ed projektu U19AI107810<\/span><\/strong><\/h2>\n

V roce 2013 NIAID ud\u011blila grant\u00a0<\/span>U19AI107810<\/span><\/a>\u00a0, v\u00fdzkumn\u00fd program sest\u00e1vaj\u00edc\u00ed z n\u011bkolika projekt\u016f s n\u00e1zvem \u201eCharakterizace nov\u00fdch gen\u016f k\u00f3dovan\u00fdch RNA a DNA viry\u201c.<\/span><\/p>\n

V r\u00e1mci programu vedl Baric vlastn\u00ed projekt s n\u00e1zvem \u201e\u00daloha necharakterizovan\u00fdch gen\u016f v infekc\u00edch vysoce patogenn\u00edmi lidsk\u00fdmi koronaviry\u201c a z\u00e1rove\u0148 byl zodpov\u011bdn\u00fd za \u0159\u00edzen\u00ed cel\u00e9ho programu a jeho administrativn\u00edho j\u00e1dra.<\/span><\/p>\n

Dal\u0161\u00ed projekty se zam\u011b\u0159ovaly na viry ch\u0159ipky, eboly a herpesu a byly podporov\u00e1ny spole\u010dn\u00fdmi kl\u00ed\u010dov\u00fdmi oblastmi biochemie, spr\u00e1vy dat a \u010dinidel.<\/span><\/p>\n

M\u00edsto v\u00fdvoje nov\u00fdch technologi\u00ed reverzn\u00ed genetiky tento program vyu\u017eil t\u011bchto schopnost\u00ed k prozkoum\u00e1n\u00ed biologick\u00fdch funkc\u00ed d\u0159\u00edve necharakterizovan\u00fdch virov\u00fdch gen\u016f, v\u010detn\u011b gen\u016f zapojen\u00fdch do infekc\u00ed vysoce patogenn\u00edmi lidsk\u00fdmi koronaviry.<\/span><\/p>\n

Financov\u00e1n\u00ed prob\u00edhalo do konce roku 2017.<\/span><\/p>\n

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2013\u20132022: Financov\u00e1n\u00ed projektu AI108197<\/span><\/strong><\/h2>\n

V roce 2013 schv\u00e1lila NIAID grantov\u00fd projekt R01\u00a0<\/span>AI108197<\/span><\/a>\u00a0s n\u00e1zvem \u201eDeterminanty replika\u010dn\u00ed p\u0159esnosti a patogeneze koronavir\u016f\u201c \u2013 projekt spolupr\u00e1ce mezi Markem Denisonem z Vanderbiltovy univerzity a spole\u010dnost\u00ed Baric.<\/span><\/p>\n

Projekt zkoumal mechanismy, kter\u00e9 \u00fadajn\u011b ur\u010duj\u00ed, jak p\u0159esn\u011b koronaviry replikuj\u00ed sv\u016fj genom a jak p\u0159esnost replikace ovliv\u0148uje virovou patogenezi.<\/span><\/p>\n

Grant byl nep\u0159etr\u017eit\u011b poskytov\u00e1n a\u017e do roku 2022, \u010d\u00edm\u017e po t\u00e9m\u011b\u0159 deset let podporoval v\u00fdzkum vztahu mezi replikac\u00ed genomu koronaviru, mutacemi a onemocn\u011bn\u00edm.<\/span><\/p>\n

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2014\u20132018: Financov\u00e1n\u00ed projektu U19AI109761<\/span><\/strong><\/h2>\n

V roce 2014 NIAID financovala projekt Ralpha Barice \u201eDiagnostick\u00e9 a prognostick\u00e9 biomarkery pro z\u00e1va\u017en\u00e1 virov\u00e1 onemocn\u011bn\u00ed plic\u201c v r\u00e1mci \u201eCentra pro v\u00fdzkum v diagnostice a objevov\u00e1n\u00ed\u201c (\u00a0<\/span>U19AI109761<\/span><\/a>\u00a0).<\/span><\/p>\n

Program, kter\u00fd se skl\u00e1dal z n\u011bkolika projekt\u016f, kombinoval studie potenci\u00e1ln\u00ed diagnostiky infek\u010dn\u00edch onemocn\u011bn\u00ed, molekul\u00e1rn\u00ed diagnostiky, syst\u00e9mov\u00e9 biologie, genomick\u00e9 identifikace a interakc\u00ed hostitel-mikroorganism, zat\u00edmco Baric\u016fv projekt se zam\u011b\u0159il na identifikaci diagnostick\u00fdch a prognostick\u00fdch biomarker\u016f spojen\u00fdch se z\u00e1va\u017en\u00fdmi plicn\u00edmi onemocn\u011bn\u00edmi.<\/span><\/p>\n

Financov\u00e1n\u00ed prob\u00edhalo do roku 2018 a podpo\u0159ilo Baric\u016fv p\u0159\u00edsp\u011bvek k \u0161ir\u0161\u00ed iniciativ\u011b NIAID, jej\u00edm\u017e c\u00edlem bylo vyvinout nov\u00e9 p\u0159\u00edstupy k diagnostice a charakterizaci z\u00e1va\u017en\u00fdch virov\u00fdch infekc\u00ed.<\/span><\/p>\n

\"\"<\/figure>\n

2015\u20132024: Financov\u00e1n\u00ed projektu AI110700<\/span><\/strong><\/h2>\n

V roce 2015 NIAID ud\u011blila grant R01 na projekt\u00a0<\/span>AI110700<\/span><\/a>\u00a0s n\u00e1zvem \u201eMechanismy vstupu MERS-CoV, mezidruhov\u00fd p\u0159enos a patogeneze\u201c Ralphu Baricovi a Fang Li.<\/span><\/p>\n

Projekt zkoumal, jak se p\u0159edpokl\u00e1d\u00e1, \u017ee koronavirus MERS vstupuje do hostitelsk\u00fdch bun\u011bk, p\u0159en\u00e1\u0161\u00ed se mezi r\u016fzn\u00fdmi druhy a zp\u016fsobuje onemocn\u011bn\u00ed.<\/span><\/p>\n

Financov\u00e1n\u00ed pokra\u010dovalo nep\u0159etr\u017eit\u011b a\u017e do konce roku 2024.<\/span><\/p>\n

Od roku 2020 byl n\u00e1zev MERS-CoV roz\u0161\u00ed\u0159en na \u201eVstup do bun\u011bk, mezidruhov\u00fd p\u0159enos a patogeneze nov\u00e9ho koronaviru\u2026\u201c, co\u017e odr\u00e1\u017e\u00ed \u0161ir\u0161\u00ed zam\u011b\u0159en\u00ed na \u201enov\u011b vznikaj\u00edc\u00ed\u201c koronaviry a z\u00e1rove\u0148 nad\u00e1le podporuje v\u00fdzkum vstupu koronavir\u016f, spektra hostitel\u016f a patogeneze.<\/span><\/p>\n

\"\"<\/figure>\n

2017\u20132021: Financov\u00e1n\u00ed projektu AI132178<\/span><\/strong><\/h2>\n

V roce 2017 NIAID ud\u011blila Ralphu Baricovi a Timothymu Sheahanovi grantovou \u017e\u00e1dost\u00a0<\/span>AI132178<\/span><\/a>\u00a0s n\u00e1zvem \u201e\u0160irokop\u00e1smov\u00e9 antivirov\u00e9 \u010dinidlo GS-5734 pro l\u00e9\u010dbu viru MERS-CoV a souvisej\u00edc\u00edch nov\u011b vznikaj\u00edc\u00edch koronavir\u016f\u201c.<\/span><\/p>\n

Projekt financoval v\u00fdzkum zam\u011b\u0159en\u00fd na hodnocen\u00ed antivirov\u00e9 slou\u010deniny GS-5734 (pozd\u011bji zn\u00e1m\u00e9 jako Remdesivir) proti koronaviru MERS a souvisej\u00edc\u00edm nov\u011b vznikaj\u00edc\u00edm koronavir\u016fm s deklarovan\u00fdm c\u00edlem vyvinout \u0161irokospektr\u00e1ln\u00ed antivirovou terapii.<\/span><\/p>\n

Grant trval do roku 2021 a v roce 2020 byl dopln\u011bn dv\u011bma dal\u0161\u00edmi granty.<\/span><\/p>\n

Financov\u00e1n\u00ed bylo pozd\u011bji uzn\u00e1no jako vl\u00e1dn\u00ed podpora v patentov\u00fdch rodin\u00e1ch spole\u010dnosti Baric \u201eViry SARS-CoV-2 adaptovan\u00e9 na my\u0161i a metody jejich pou\u017eit\u00ed\u201c a \u201eViry SARS-CoV-2 a metody jejich pou\u017eit\u00ed\u201c.<\/span><\/p>\n

\"\"<\/figure>\n

2019\u20132023: Financov\u00e1n\u00ed AI149644<\/span><\/strong><\/h2>\n

V roce 2019 NIAID ud\u011blila spole\u010dnosti Baric grant U01\u00a0<\/span>AI149644<\/span><\/a>\u00a0s n\u00e1zvem \u201eV\u00fdzkum vakc\u00edn a adjuvanci\u00ed proti respira\u010dn\u00edm vir\u016fm\u201c.<\/span><\/p>\n

Projekt financoval v\u00fdzkum v\u00fdvoje a hodnocen\u00ed vakcina\u010dn\u00edch strategi\u00ed a adjuvanci\u00ed pro respira\u010dn\u00ed viry, \u010d\u00edm\u017e poskytl vl\u00e1dn\u00ed financov\u00e1n\u00ed pro v\u00fdzkum vakcina\u010dn\u00edch platforem pou\u017eiteln\u00fdch pro nov\u011b vznikaj\u00edc\u00ed respira\u010dn\u00ed patogeny.<\/span><\/p>\n

Financov\u00e1n\u00ed prob\u00edhalo do roku 2023 a v roce 2020 bylo dopln\u011bno grantem na vybaven\u00ed, co\u017e odr\u00e1\u017e\u00ed trval\u00fd z\u00e1vazek NIAID k programu v\u00fdvoje vakc\u00edn spole\u010dnosti Barics.<\/span><\/p>\n

Financov\u00e1n\u00ed bylo pozd\u011bji uzn\u00e1no jako vl\u00e1dn\u00ed podpora v patentov\u00fdch rodin\u00e1ch \u201eViry SARS-CoV-2 adaptovan\u00e9 na my\u0161i a metody jejich pou\u017eit\u00ed\u201c a \u201eViry SARS-CoV-2 a metody jejich pou\u017eit\u00ed\u201c.<\/span><\/p>\n

\"\"<\/figure>\n

2020\u20132024: Program financov\u00e1n\u00ed U54 CA260543<\/span><\/strong><\/h2>\n

V roce 2020 N\u00e1rodn\u00ed onkologick\u00fd institut (NCI), institut NIH, ud\u011blil grantov\u00fd program\u00a0<\/span>U54 CA260543<\/span><\/a>\u00a0, \u010d\u00edm\u017e zalo\u017eil Centrum excelence pro seronet v Severn\u00ed Karol\u00edn\u011b.<\/span><\/p>\n

V\u00edceprojektov\u00fd program, kter\u00fd spoluvedl Ralph Baric, podporoval v\u00fdzkum imunity proti SARS-CoV-2, v\u010detn\u011b s\u00e9rologick\u00fdch korel\u00e1t\u016f imunity a onemocn\u011bn\u00ed, protil\u00e1tkov\u00fdch odpov\u011bd\u00ed na SARS-CoV-2 a dal\u0161\u00ed patogenn\u00ed lidsk\u00e9 koronaviry, imunoglobulinov\u00e9 proteomiky, plazmatick\u00e9 terapie a po\u0161kozen\u00ed tk\u00e1n\u00ed spojen\u00e9ho s COVID-19, spolu s vyhrazen\u00fdmi administrativn\u00edmi a sd\u00edlen\u00fdmi zdroji.<\/span><\/p>\n

Financov\u00e1n\u00ed centra bylo zaji\u0161t\u011bno minim\u00e1ln\u011b do roku 2024.<\/span><\/p>\n

Financov\u00e1n\u00ed bylo pozd\u011bji uzn\u00e1no jako vl\u00e1dn\u00ed podpora v Baricov\u011b patentov\u00e9 p\u0159ihl\u00e1\u0161ce \u201eLidsk\u00e9 monoklon\u00e1ln\u00ed protil\u00e1tky c\u00edl\u00edc\u00ed na podjednotku S2 hrotov\u00e9ho proteinu SARS-CoV-2\u201c.<\/span><\/p>\n

2021\u20132023: Financov\u00e1n\u00ed AI158571<\/span><\/strong><\/h2>\n

V roce 2021 financoval NIAID multiprojektov\u00fd program \u201eN\u00e1vrh a v\u00fdvoj vakc\u00edny proti pan-betakoronaviru\u201c (\u00a0<\/span>P01AI158571<\/span><\/a>\u00a0).<\/span><\/p>\n

Program podporoval koordinovan\u00fd v\u00fdzkum pan-betakoronavirov\u00fdch vakc\u00edn, n\u00e1vrh pan-betakoronavirov\u00fdch proteinov\u00fdch vakc\u00edn, nukleosidov\u011b modifikovan\u00fdch vakcina\u010dn\u00edch platforem mRNA-LNP, po\u010d\u00edta\u010dem podporovan\u00fd n\u00e1vrh pan-betakoronavirov\u00fdch imunogen\u016f a speci\u00e1ln\u00ed kl\u00ed\u010dov\u00e9 oblasti pro biologickou bezpe\u010dnost, imunitn\u00ed dohled a prim\u00e1ty.<\/span><\/p>\n

Financov\u00e1n\u00ed prob\u00edhalo nejm\u00e9n\u011b do roku 2023 a podporovalo integrovanou iniciativu na v\u00fdvoj vakcina\u010dn\u00edch platforem, kter\u00e9 by nab\u00edzely ochranu proti v\u00edce betakoronavir\u016fm, sp\u00ed\u0161e ne\u017e jen proti jednomu kmenu koronaviru.<\/span><\/p>\n

\"\"<\/figure>\n

2022: Financov\u00e1n\u00ed AI171292<\/span><\/strong><\/h2>\n

V roce 2022 NIAID ud\u011blila finan\u010dn\u00ed prost\u0159edky projektu\u00a0<\/span>U19AI171292<\/span><\/a>\u00a0s n\u00e1zvem \u201eRapidly Emerging Antivirotic Drug Development Initiative \u2013 AViDD Center\u201c (READDI-AC), kter\u00fd spole\u010dn\u011b vedou Ralph Baric a Timothy Willson.<\/span><\/p>\n

Program, kter\u00fd se skl\u00e1dal z n\u011bkolika projekt\u016f, podporoval v\u00fdzkum a v\u00fdvoj \u0161irokospektr\u00fdch antivirotik, v\u010detn\u011b specifick\u00fdch projekt\u016f pro v\u00fdvoj hlavn\u00edch antivirov\u00fdch slou\u010denin proti koronavir\u016fm, jako\u017e i kombinovan\u00fdch test\u016f a \u0161irokospektr\u00fdch antivirotik zam\u011b\u0159en\u00fdch na replik\u00e1zu a helik\u00e1zu koronavir\u016f, spolu s kl\u00ed\u010dov\u00fdmi oblastmi medicin\u00e1ln\u00ed chemie, enzymologie a objevov\u00e1n\u00ed l\u00e9\u010div.<\/span><\/p>\n

Financov\u00e1n\u00ed p\u0159edstavovalo dal\u0161\u00ed roz\u0161\u00ed\u0159en\u00ed dlouhodob\u00e9ho, feder\u00e1ln\u011b financovan\u00e9ho v\u00fdzkumn\u00e9ho programu koronaviru spole\u010dnosti Baric, kter\u00fd p\u0159esunul sv\u00e9 zam\u011b\u0159en\u00ed z pochopen\u00ed biologie koronaviru a v\u00fdvoje experiment\u00e1ln\u00edch syst\u00e9m\u016f na identifikaci a v\u00fdvoj kandid\u00e1tn\u00edch l\u00e9\u010div proti koronavir\u016fm a dal\u0161\u00edm nov\u011b vznikaj\u00edc\u00edm vir\u016fm.<\/span><\/p>\n

\"\"<\/figure>\n

2022\u20132026: Financov\u00e1n\u00ed projektu AI167966<\/span><\/strong><\/h2>\n

V roce 2022 financoval NIAID v\u00edceprojektov\u00fd program \u201eStruktur\u00e1ln\u011b zalo\u017een\u00fd n\u00e1vrh \u0161iroce ochrann\u00fdch vakc\u00edn proti koronaviru\u201c (\u00a0<\/span>P01AI167966<\/span><\/a>\u00a0).<\/span><\/p>\n

Program podporoval koordinovan\u00fd v\u00fdzkum v oblasti n\u00e1vrhu vakc\u00edn proti koronaviru zalo\u017een\u00e9ho na struktu\u0159e, n\u00e1vrhu vakc\u00edn s nano\u010d\u00e1sticemi, \u0161irok\u00e9 humor\u00e1ln\u00ed imunity proti koronavir\u016fm, evoluce vir\u016f, preklinick\u00e9 testov\u00e1n\u00ed vakc\u00edn a specifick\u00fdch kl\u00ed\u010dov\u00fdch oblast\u00ed proteinov\u00e9 v\u011bdy, virologie a v\u00fdzkumu prim\u00e1t\u016f.<\/span><\/p>\n

Bari\u0107 vedl hlavn\u00ed oblast virologie programu.<\/span><\/p>\n

Financov\u00e1n\u00ed prob\u00edhalo nejm\u00e9n\u011b do roku 2026 a podporovalo integrovan\u00e9 \u00fasil\u00ed o v\u00fdvoj vakc\u00edn, kter\u00e9 by nab\u00edzely \u0161irokou ochranu proti v\u00edce koronavir\u016fm, sp\u00ed\u0161e ne\u017e jen proti jednomu kmenu koronaviru.<\/span><\/p>\n

\"\"<\/figure>\n

V\u00fdvoj patent\u016f na koronavirus s vyu\u017eit\u00edm feder\u00e1ln\u00edch finan\u010dn\u00edch prost\u0159edk\u016f<\/span><\/strong><\/h2>\n

2006: cDNA infek\u010dn\u00edho koronaviru SARS \/ Reverzn\u00ed genetika<\/span><\/strong><\/p>\n

US 2006\/0240530 A1<\/span><\/a>\u00a0\u2014\u00a0<\/span>AI023946<\/span><\/a>\u00a0;\u00a0<\/span>GM063228<\/span><\/a><\/p>\n

2016: Diagnostika koronaviru<\/span><\/strong><\/p>\n

US 2016\/0238601 A1<\/span><\/a>\u00a0\u2014\u00a0<\/span>AI085524<\/span><\/a>\u00a0,\u00a0<\/span>AI057157<\/span><\/a>\u00a0a\u00a0<\/span>U19AI107810<\/span><\/a><\/p>\n

2017\u20132018: Chim\u00e9rick\u00e9 spike proteiny koronaviru<\/span><\/strong><\/p>\n

US 2017\/0096455 A1<\/span><\/a>\u00a0; US \u200b\u200bpatent\u00a0<\/span>9 884 895<\/span><\/a>\u00a0\u2014\u00a0<\/span>U54AI057157<\/span><\/a><\/p>\n

2021\u20132022: My\u0161\u00edm adaptovan\u00e9 a report\u00e9rov\u00e9 \u200b\u200bviry SARS-CoV-2<\/span><\/strong><\/p>\n

Americk\u00e9 patenty\u00a0<\/span>11 225 508<\/span><\/a>\u00a0a\u00a0<\/span>11 492 379<\/span><\/a>\u00a0\u2014\u00a0<\/span>AI132178<\/span><\/a>\u00a0;\u00a0<\/span>AI142759<\/span><\/a>\u00a0;\u00a0<\/span>AI100625<\/span><\/a>\u00a0;\u00a0<\/span>AI108197<\/span><\/a>\u00a0;\u00a0<\/span>AI089728<\/span><\/a>\u00a0;\u00a0<\/span>AI149644<\/span><\/a>\u00a0;\u00a0<\/span>HHSN2722017000361<\/span><\/a><\/p>\n

2023: L\u00e9\u010dba koronaviru<\/span><\/strong><\/p>\n

US 2023\/0137667 A1<\/span><\/a>\u00a0\u2014\u00a0<\/span>AI106772<\/span><\/a><\/p>\n

2025: Monoklon\u00e1ln\u00ed protil\u00e1tky proti SARS-CoV-2<\/span><\/strong><\/p>\n

US 2025\/0145691 A1<\/span><\/a>\u00a0\u2014\u00a0<\/span>U54CA260543<\/span><\/a><\/p>\n

Z\u00e1v\u011br<\/span><\/strong><\/h2>\n

Ve\u0159ejn\u011b dostupn\u00e9 dokumenty neukazuj\u00ed \u017e\u00e1dnou s\u00e9rii izolovan\u00fdch program\u016f financov\u00e1n\u00ed koronavir\u016f.<\/span><\/p>\n

Sp\u00ed\u0161e demonstruj\u00ed nep\u0159etr\u017eit\u00e9 investice feder\u00e1ln\u00ed vl\u00e1dy po v\u00edce ne\u017e \u010dty\u0159i desetilet\u00ed.<\/span><\/p>\n

Od Bari\u0107ova prvn\u00edho v\u00fdzkumu koronaviru financovan\u00e9ho NIH v roce 1984 je v grantov\u00fdch dokumentech patrn\u00fd jasn\u00fd v\u00fdvoj: od vysv\u011btlov\u00e1n\u00ed \u00fadajn\u00e9ho fungov\u00e1n\u00ed genov\u00fdch sekvenc\u00ed koronaviru, p\u0159es v\u00fdvoj technologi\u00ed pro manipulaci a genetickou modifikaci genom\u016f koronaviru, a\u017e po prov\u00e1d\u011bn\u00ed pozd\u011bj\u0161\u00ed mutageneze a experiment\u016f se ziskem funkce a nakonec k v\u00fdvoji diagnostick\u00fdch metod, antivirov\u00fdch l\u00e9k\u016f a vakc\u00edn.<\/span><\/p>\n

Granty, publikace a patenty dokumentuj\u00ed dlouhodob\u00fd v\u00fdvoj v\u00fdzkumn\u00e9ho projektu Ralpha Barice v oblasti koronaviru, kter\u00fd financuje vl\u00e1da USA.<\/span><\/p>\n

Od Jona Fleetwooda<\/span><\/em><\/strong><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Chronologick\u00fd seznam financov\u00e1n\u00ed, publikac\u00ed a patent\u016f NIH dokumentuje v\u00edce ne\u017e \u010dty\u0159i desetilet\u00ed nep\u0159etr\u017eit\u00fdch vl\u00e1dn\u00edch investic…<\/p>\n","protected":false},"author":2,"featured_media":112401,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1042,45,2573,37,99,1820],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/112400"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=112400"}],"version-history":[{"count":1,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/112400\/revisions"}],"predecessor-version":[{"id":112402,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/112400\/revisions\/112402"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/112401"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=112400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=112400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=112400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}