{"id":111332,"date":"2026-07-23T00:12:59","date_gmt":"2026-07-22T22:12:59","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=111332"},"modified":"2026-07-22T11:36:29","modified_gmt":"2026-07-22T09:36:29","slug":"za-hranicemi-laboratornich-ohnisek-a-prirozeneho-prelevani-teorie-in-silico-o-stadiu-pandemii","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/07\/23\/za-hranicemi-laboratornich-ohnisek-a-prirozeneho-prelevani-teorie-in-silico-o-stadiu-pandemii\/","title":{"rendered":"Za hranicemi laboratorn\u00edch ohnisek a p\u0159irozen\u00e9ho p\u0159el\u00e9v\u00e1n\u00ed: \u201eTeorie in silico\u201c o stadiu pandemi\u00ed"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"has-medium-font-size wp-block-paragraph\"><strong><span dir=\"auto\">T\u0159et\u00ed p\u0159\u00edstup k pochopen\u00ed modern\u00edch pandemi\u00ed<\/span><\/strong><\/h3>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Debata o p\u016fvodu COVID-19 se ji\u017e v\u00edce ne\u017e p\u011bt let z velk\u00e9 \u010d\u00e1sti omezuje na dva protich\u016fdn\u00e9 vysv\u011btluj\u00edc\u00ed p\u0159\u00edstupy.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Bu\u010f SARS-CoV-2 vznikl p\u0159irozen\u011b z divok\u00fdch zv\u00ed\u0159at a p\u0159enesl se na \u010dlov\u011bka.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Nebo uniklo z laborato\u0159e b\u011bhem v\u00fdzkumu koronavir\u016f.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Ale co kdy\u017e oba vysv\u011btluj\u00edc\u00ed p\u0159\u00edstupy kladou \u0161patnou ot\u00e1zku?<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Co kdy\u017e kl\u00ed\u010dovou infrastrukturou modern\u00ed pandemie nen\u00ed samotn\u00fd fyzick\u00fd patogen, ale informa\u010dn\u00ed architektura, kter\u00e1 ho obklopuje?<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Tato publikace ozna\u010duje tuto mo\u017enost jako\u00a0<\/span><strong><span dir=\"auto\">teorii in silico<\/span><\/strong><span dir=\"auto\">\u00a0, odvozenou od\u00a0<\/span><em><span dir=\"auto\">in silico<\/span><\/em><span dir=\"auto\">\u00a0\u2013 kter\u00e9 ozna\u010duje procesy prob\u00edhaj\u00edc\u00ed uvnit\u0159 po\u010d\u00edta\u010de, nikoli ve fyzick\u00e9m sv\u011bt\u011b.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">\u201eTeorie in silico\u201c se nepokou\u0161\u00ed rozhodnout mezi p\u0159enosem ze sv\u011bta zv\u00ed\u0159at a \u00fanikem z laborato\u0159e jako\u017eto konkuren\u010dn\u00edmi vysv\u011btluj\u00edc\u00edmi p\u0159\u00edstupy.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">M\u00edsto toho p\u0159edpokl\u00e1d\u00e1, \u017ee modern\u00ed pandemie jsou st\u00e1le v\u00edce operacionalizov\u00e1ny prediktivn\u00edmi algoritmy, genomick\u00fdmi referen\u010dn\u00edmi architekturami, laboratorn\u011b generovan\u00fdmi sekven\u010dn\u00edmi informacemi, syst\u00e9my dohledu, po\u010d\u00edta\u010dem podporovanou epidemiologi\u00ed, diagnostikou a farmaceutick\u00fdmi platformami, kter\u00e9 dohromady tvo\u0159\u00ed sebeposiluj\u00edc\u00ed informa\u010dn\u00ed ekosyst\u00e9m.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V takov\u00e9m kontextu z\u016fst\u00e1vaj\u00ed laborato\u0159e nepostradateln\u00e9 \u2013 ne nutn\u011b jako v\u00fdchoz\u00ed bod pandemie, ale jako kl\u00ed\u010dov\u00e1 centra p\u0159i vytv\u00e1\u0159en\u00ed, zdokonalov\u00e1n\u00ed, validaci a operacionalizaci informa\u010dn\u00edch syst\u00e9m\u016f, kter\u00e9 tuto pandemii definuj\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V takov\u00e9m modelu se \u00fast\u0159edn\u00ed ot\u00e1zka p\u0159esouv\u00e1 z:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">&#8222;Odkud ten patogen poch\u00e1z\u00ed?&#8220;<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">k:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eKdo navrhl syst\u00e9my, kter\u00e9 definuj\u00ed, co je patogen?\u201c<\/span><\/em><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Desetilet\u00ed trvaj\u00edc\u00ed expanze DARPA<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Od roku 2010 spustila americk\u00e1 arm\u00e1da, p\u0159edev\u0161\u00edm prost\u0159ednictv\u00edm DARPA, \u0159adu program\u016f, kter\u00e9, jak se zd\u00e1, st\u00e1le v\u00edce sni\u017euj\u00ed pot\u0159ebu p\u0159edpokl\u00e1dat rozpoznan\u00e9 ohnisko n\u00e1kazy, rozs\u00e1hlou epidemii nebo dokonce konven\u010dn\u011b charakterizovan\u00fd patogen.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Dokumenty samotn\u00e9 DARPA m\u00edsto toho popisuj\u00ed architekturu, kter\u00e1 se st\u00e1le v\u00edce spol\u00e9h\u00e1 na p\u0159edpov\u011bzen\u00e9 mutace, data elektronick\u00fdch sekvenc\u00ed, po\u010d\u00edta\u010dov\u00e9 modely a farmaceutick\u00e1 protiopat\u0159en\u00ed, je\u017e jsou vyvinuta d\u0159\u00edve, ne\u017e je \u00fadajn\u011b pot\u0159eba.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Tyto snahy nebyly utajeny.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Samotn\u00e1 DARPA\u00a0<\/span><a href=\"https:\/\/www.darpa.mil\/sites\/default\/files\/Preventing_Pandemics_Vignette_Final_210208.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">popsala<\/span><\/a><span dir=\"auto\">\u00a0pr\u00e1ci jako:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eOdv\u00e1\u017en\u00e9 portfolio projekt\u016f navr\u017een\u00e9 k vytvo\u0159en\u00ed know-how pro zvl\u00e1d\u00e1n\u00ed pandemi\u00ed\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">pro rychlou prevenci, diagnostiku a l\u00e9\u010dbu infek\u010dn\u00edch onemocn\u011bn\u00ed,<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201edokonce i takov\u00e9, jak\u00e9 sv\u011bt je\u0161t\u011b nikdy nevid\u011bl\u201c.<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Ka\u017ed\u00fd program, posuzovan\u00fd jednotliv\u011b, lze ch\u00e1pat jako iniciativu biologick\u00e9 obrany.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Dohromady se v\u0161ak zd\u00e1, \u017ee popisuj\u00ed n\u011bco mnohem v\u011bt\u0161\u00edho:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">pandemick\u00e1 architektura navr\u017een\u00e1 tak, aby se posunula od model\u016f p\u0159es sekven\u010dn\u00ed informace k intervenc\u00edm a nakonec k nasazen\u00ed.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Krok jedna: P\u0159edv\u00edd\u00e1n\u00ed budouc\u00edho patogenu<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Prvn\u00ed \u00farove\u0148 byla vytvo\u0159ena v roce 2010 v r\u00e1mci programu PROPHECY agentury DARPA.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA\u00a0<\/span><a href=\"https:\/\/sam.gov\/workspace\/contract\/opp\/70a6f6bffbd9b25789ee09d0810599cb\/view\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">si kladla za c\u00edl<\/span><\/a><span dir=\"auto\">\u00a0dos\u00e1hnout n\u00e1sleduj\u00edc\u00edho:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eVyvinout technologie, kter\u00e9 p\u0159edpov\u00eddaj\u00ed p\u0159irozen\u00fd v\u00fdvoj vir\u016f\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><strong><span dir=\"auto\">a:<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">&#8222;Abychom mohli p\u0159edv\u00eddat mutace a p\u0159\u00edpadn\u011b i p\u0159eskupen\u00ed.&#8220;<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pro v\u011bt\u0161inu \u010dten\u00e1\u0159\u016f se toto zn\u011bn\u00ed nemus\u00ed zpo\u010d\u00e1tku zd\u00e1t neobvykl\u00e9.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V tradi\u010dn\u00edm ch\u00e1p\u00e1n\u00ed ve\u0159ejn\u00e9ho zdrav\u00ed v\u0161ak v\u011bdci nejprve pozoruj\u00ed patogen, charakterizuj\u00ed ho a teprve pot\u00e9 za\u010d\u00ednaj\u00ed vyv\u00edjet opat\u0159en\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">PROROCTV\u00cd navrhovalo obr\u00e1tit toto po\u0159ad\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA si p\u0159edstavovala n\u00e1sleduj\u00edc\u00ed:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201ePrediktivn\u00ed algoritmy, kter\u00e9 jsou z\u00e1sobov\u00e1ny daty pomoc\u00ed vysoce v\u00fdkonn\u00fdch biologick\u00fdch platforem a experiment\u00e1ln\u011b ov\u011b\u0159ov\u00e1ny\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">spolu s:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">&#8222;Integrace platformy pro virovou evoluci s algoritmem, kter\u00fd p\u0159edpov\u00edd\u00e1 mutace.&#8220;<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Snad nejpozoruhodn\u011bj\u0161\u00ed je, \u017ee DARPA popsala\u00a0<\/span><a href=\"https:\/\/www.darpa.mil\/research\/programs\/prophecy-pathogen-defeat\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">kone\u010dn\u00fd<\/span><\/a><span dir=\"auto\">\u00a0c\u00edl takto:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">&#8222;V kone\u010dn\u00e9m d\u016fsledku jde o v\u00fdvoj l\u00e9k\u016f a vakc\u00edn je\u0161t\u011b p\u0159edt\u00edm, ne\u017e je to pot\u0159eba.&#8220;<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V r\u00e1mci in silico p\u0159edstavuje PROROCTV\u00cd \u00farove\u0148 predikce.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Model je na prvn\u00edm m\u00edst\u011b.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pozorov\u00e1n\u00ed je a\u017e na druh\u00e9m m\u00edst\u011b.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Krok dva: P\u0159evod sekven\u010dn\u00edch informac\u00ed do protiopat\u0159en\u00ed<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V n\u00e1sleduj\u00edc\u00edm roce vy\u0161lo album ADEPT.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA za\u010dala masivn\u011b investovat do toho, co\u00a0<\/span><a href=\"https:\/\/www.darpa.mil\/sites\/default\/files\/Preventing_Pandemics_Vignette_Final_210208.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">naz\u00fdvala<\/span><\/a><span dir=\"auto\">\u00a0:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201egenov\u011b k\u00f3dovan\u00e9 vakc\u00edny\u201c.<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">M\u00edsto produkce velk\u00e9ho mno\u017estv\u00ed patogenn\u00edho materi\u00e1lu a p\u0159\u00edm\u00e9ho pod\u00e1v\u00e1n\u00ed protein\u016f pl\u00e1novala DARPA podat:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">Geny k\u00f3duj\u00edc\u00ed imunostimula\u010dn\u00ed antigeny<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">p\u0159\u00edjemc\u016fm.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA uvedla, \u017ee:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eInstrukce obsa\u017een\u00e9 v DNA nebo RNA stimuluj\u00ed vlastn\u00ed bu\u0148ky t\u011bla k produkci antigenn\u00edho virov\u00e9ho proteinu.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Provozn\u00ed vstupy se st\u00e1le v\u00edce st\u00e1valy samotn\u00fdmi informacemi.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pokud PROROCTV\u00cd znamenalo p\u0159edpov\u011b\u010f, ADEPT znamenalo realizaci:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">p\u0159evod sekven\u010dn\u00edch informac\u00ed do farmaceutick\u00fdch protiopat\u0159en\u00ed.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Krok 3: Jedn\u00e1n\u00ed v\u00fdhradn\u011b na z\u00e1klad\u011b informac\u00ed o sekvenci<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Dal\u0161\u00ed f\u00e1z\u00ed n\u00e1sledovala Platforma pro prevenci pandemie (P3) od DARPA.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA\u00a0<\/span><a href=\"https:\/\/www.darpa.mil\/sites\/default\/files\/Preventing_Pandemics_Vignette_Final_210208.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">popsala<\/span><\/a><span dir=\"auto\">\u00a0P3 jako:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201enavazuj\u00edc\u00ed iniciativa na program ADEPT\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">s c\u00edlem<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201edos\u00e1hnout v\u00fdvoje a \u0161irok\u00e9ho zaveden\u00ed ochrann\u00fdch opat\u0159en\u00ed do 60 dn\u016f.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Jinde DARPA\u00a0<\/span><a href=\"https:\/\/www.darpa.mil\/research\/programs\/pandemic-prevention-platform\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">popsala<\/span><\/a><span dir=\"auto\">\u00a0c\u00edl takto:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eb\u00fdt schopen vyrobit odpov\u00eddaj\u00edc\u00ed po\u010det d\u00e1vek proti zn\u00e1m\u00e9 nebo d\u0159\u00edve nezn\u00e1m\u00e9 infek\u010dn\u00ed hrozb\u011b do 60 dn\u016f od jej\u00ed identifikace.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pak p\u0159i\u0161lo asi nejodhaluj\u00edc\u00ed prohl\u00e1\u0161en\u00ed v r\u00e1mci pandemick\u00e9ho portfolia DARPA.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">\u00da\u010dastn\u00edci P3\u00a0<\/span><a href=\"https:\/\/usrtk.org\/wp-content\/uploads\/2025\/10\/21-F-0004-09.2025-Doc-REDACTED.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">vysv\u011btlili<\/span><\/a><span dir=\"auto\">\u00a0:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eProto\u017ee si uv\u011bdomujeme, \u017ee b\u011bhem pandemie mohou b\u00fdt k dispozici pouze elektronick\u00e9 informace o virov\u00e9 sekvenci\u2026\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">optimalizovali by metody pro:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eSynt\u00e9za bezchybn\u00e9ho genomu klonu infek\u010dn\u00edho viru pro p\u0159\u00edmou transfekci.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">D\u016fle\u017eitost tohoto prohl\u00e1\u0161en\u00ed nelze p\u0159ece\u0148ovat.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA se v\u00fdslovn\u011b p\u0159ipravovala na sc\u00e9n\u00e1\u0159e, ve kter\u00fdch by v\u011bdci mohli m\u00edt k dispozici pouze digit\u00e1ln\u00ed sekvenci na obrazovce po\u010d\u00edta\u010de, se kterou by mohli pracovat, a p\u0159esto by mohli p\u0159\u00edmo pokra\u010dovat ve v\u00fdrob\u011b protiopat\u0159en\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Architektura byla z\u00e1m\u011brn\u011b navr\u017eena tak, aby fungovala i v situac\u00edch, kdy:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">&#8222;pravd\u011bpodobn\u011b jsou k dispozici pouze elektronick\u00e9 informace o virov\u00e9 sekvenci.&#8220;<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V kontextu \u201eIn Silico\u201c to p\u0159edstavuje z\u00e1sadn\u00ed zm\u011bnu.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pozornost se p\u0159esouv\u00e1 od fyzick\u00e9ho pozorov\u00e1n\u00ed k samotn\u00e9 informaci.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Krok 4: Vytvo\u0159en\u00ed syst\u00e9m\u016f pro rozpozn\u00e1v\u00e1n\u00ed model\u016f<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V roce 2018 spustila DARPA program PREEMPT, jeho\u017e c\u00edlem je\u00a0<\/span><em><span dir=\"auto\">apriorn\u011b<\/span><\/em><span dir=\"auto\">\u00a0generovat p\u0159edpov\u011bdi (neboli \u201ealibi\u201c) pro budouc\u00ed pandemick\u00e9 patogeny, kter\u00e9 se p\u0159enesou ze zv\u00ed\u0159at na lidi.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Agentura argumentovala, \u017ee st\u00e1vaj\u00edc\u00ed syst\u00e9my ve\u0159ejn\u00e9ho zdravotnictv\u00ed jsou p\u0159\u00edli\u0161 reaktivn\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA\u00a0<\/span><a href=\"https:\/\/assets.ctfassets.net\/syq3snmxclc9\/6K3RxB1DVf6ZhVxQLSJzxl\/6be5c276bc8af7921ce6b23f0975a6c3\/A_prempt-background-hr001118s0017.pdf\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">si st\u011b\u017eovala<\/span><\/a><span dir=\"auto\">\u00a0, \u017ee:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eReakce na ohniska n\u00e1kazy je do zna\u010dn\u00e9 m\u00edry reaktivn\u00ed a zahajuje se a\u017e pot\u00e9, co epidemie ji\u017e za\u010dala.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">PREEMPT si kladl za c\u00edl dos\u00e1hnout toho, co DARPA popsala takto:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eradik\u00e1ln\u00ed odklon od sou\u010dasn\u00e9 praxe\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">kter\u00fd by m\u011bl dos\u00e1hnout n\u00e1sleduj\u00edc\u00edho:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eaby se zabr\u00e1nilo jejich infiltraci do lidsk\u00e9 populace p\u0159ed vypuknut\u00edm n\u00e1kazy.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Program m\u011bl n\u00e1sleduj\u00edc\u00ed c\u00edl:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eVyvinout nov\u00e9 n\u00e1stroje a modely pro kvantifikaci pravd\u011bpodobnosti, \u017ee se kvazidruh (QS) viru p\u0159enese ze zv\u00ed\u0159ec\u00edho hostitele na \u010dlov\u011bka.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">\u00da\u010dastn\u00edci projektu byli instruov\u00e1ni k pou\u017eit\u00ed n\u00e1sleduj\u00edc\u00edch metod:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eVysokokapacitn\u00ed metody screeningu vir\u016f, metagenomika, ekologick\u00fd monitoring a pokro\u010dil\u00e9 modelovac\u00ed n\u00e1stroje\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">na<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201epokro\u010dil\u00e9 integrovan\u00e9 modely\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">vytvo\u0159it, kter\u00e9 jsou schopny<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eaby se zabr\u00e1nilo v\u00fdskytu vir\u016f u lid\u00ed d\u0159\u00edve, ne\u017e se virus dostane do lidsk\u00e9 populace.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V\u00fdzkumn\u00edci byli d\u00e1le instruov\u00e1ni, aby identifikovali n\u00e1sleduj\u00edc\u00ed:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201egenetick\u00e9 adaptace, kter\u00e9 umo\u017e\u0148uj\u00ed druhov\u00fd skok\u201c,<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Vyvinout n\u00e1sleduj\u00edc\u00ed:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eMapy genotyp\u016f a fenotyp\u016f\u201c,<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">K identifikaci n\u00e1sleduj\u00edc\u00edch bod\u016f:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201especifick\u00e9 mutace\u201c,<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">a modelovat n\u00e1sleduj\u00edc\u00ed:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201evirov\u00e9 evolu\u010dn\u00ed procesy\u201c.<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pak p\u0159i\u0161la mo\u017en\u00e1 nejd\u016fle\u017eit\u011bj\u0161\u00ed v\u011bta v cel\u00e9 pandemick\u00e9 architektu\u0159e DARPA:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201eV\u00fdsledky model\u016f TA1 in silico budou vod\u00edtkem pro n\u00e1vrh preventivn\u00edch opat\u0159en\u00ed.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Sm\u011br kauzality je kl\u00ed\u010dov\u00fd.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA neuvedla, \u017ee by pozorov\u00e1n\u00ed m\u011bla v\u00e9st modely.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">DARPA uvedla, \u017ee modely budou vod\u00edtkem pro intervence.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V r\u00e1mci in silico:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Zaprv\u00e9, model.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pak preventivn\u00ed koncept.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Za t\u0159et\u00ed, monitorov\u00e1n\u00ed a validace.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Krok 5: Aktivace architektury<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Do konce desetilet\u00ed se zd\u00e1lo, \u017ee t\u00e9m\u011b\u0159 ka\u017ed\u00e1 \u00farove\u0148 architektury je na sv\u00e9m m\u00edst\u011b.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">PROROCTV\u00cd se zam\u011b\u0159ovalo na p\u0159edpov\u011bdi.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">ADEPT se zam\u011b\u0159il na p\u0159evod sekven\u010dn\u00edch informac\u00ed do protiopat\u0159en\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">P3 se zam\u011b\u0159il na p\u0159\u00edm\u00e9 vyu\u017eit\u00ed elektronick\u00fdch sekven\u010dn\u00edch informac\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">PREEMPT se zam\u011b\u0159il na integraci po\u010d\u00edta\u010dov\u00fdch model\u016f, monitorovac\u00edch syst\u00e9m\u016f a preventivn\u00edch koncept\u016f.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pozd\u011bj\u0161\u00ed n\u00e1vrh DEFUSE si kladl za c\u00edl spojit monitorov\u00e1n\u00ed voln\u011b \u017eij\u00edc\u00edch \u017eivo\u010dich\u016f, ter\u00e9nn\u00ed pr\u00e1ci v oblasti koronaviru a interven\u010dn\u00ed strategie do jednoho r\u00e1mce.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pak p\u0159i\u0161la operace Warp Speed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Genomov\u00e9 sekvence se staly z\u00e1kladem pro diagnostick\u00e9 testy.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">C\u00edle PCR se staly definicemi p\u0159\u00edpad\u016f.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Po\u010d\u00edta\u010dem podporovan\u00e9 epidemiologick\u00e9 modely p\u0159enosu.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">\u0160\u00ed\u0159en\u00ed sledovaly syst\u00e9my dohledu.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Farmaceutick\u00e9 platformy rychle vyvinuly protiopat\u0159en\u00ed zalo\u017een\u00e1 na sekvenc\u00edch.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Ka\u017ed\u00e1 d\u016fle\u017eit\u00e1 opera\u010dn\u00ed slo\u017eka reakce na pandemii prob\u00edhala prost\u0159ednictv\u00edm informa\u010dn\u00edch syst\u00e9m\u016f.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Architektura byla digit\u00e1ln\u00ed d\u00e1vno p\u0159edt\u00edm, ne\u017e se stala biologickou.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Za hranicemi p\u016fvodu<\/span><\/strong><\/h2>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">\u201eTeorie in silico\u201c si neklade za c\u00edl objasnit, zda COVID vznikl u divok\u00fdch zv\u00ed\u0159at nebo v laborato\u0159i.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Tvrd\u00ed, \u017ee p\u016fvodn\u00ed debata sama o sob\u011b mohla p\u0159ehl\u00ed\u017eet v\u011bt\u0161\u00ed probl\u00e9m.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Do roku 2020 m\u011bly vl\u00e1dy syst\u00e9my schopn\u00e9 \u201ep\u0159edpov\u00eddat\u201c p\u0159edpokl\u00e1dan\u00e9 budouc\u00ed vlastnosti patogen\u016f, generovat opat\u0159en\u00ed je\u0161t\u011b p\u0159edt\u00edm, ne\u017e vznikla pot\u0159eba, pracovat na z\u00e1klad\u011b elektronick\u00fdch sekven\u010dn\u00edch informac\u00ed, prov\u00e1d\u011bt glob\u00e1ln\u00ed dohled, definovat p\u0159\u00edpady pomoc\u00ed molekul\u00e1rn\u00ed diagnostiky, po\u010d\u00edta\u010dov\u011b podporovan\u00e9 modelov\u00e1n\u00ed \u0161\u00ed\u0159en\u00ed a zav\u00e1d\u011bt farmaceutick\u00e1 protiopat\u0159en\u00ed neb\u00fdvalou rychlost\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Samotn\u00e1 DARPA popsala toto \u00fasil\u00ed jako technologie pro boj s nemocemi:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201ejak to sv\u011bt je\u0161t\u011b nikdy nevid\u011bl.\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Jejich programy si kladly za c\u00edl rozv\u00edjet n\u00e1sleduj\u00edc\u00ed:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">Vakc\u00edny \u201eje\u0161t\u011b p\u0159edt\u00edm, ne\u017e jsou pot\u0159eba\u201c<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">kter\u00e9 se pou\u017e\u00edvaj\u00ed, kdy\u017e:<\/span><\/p>\n<p><em><span dir=\"auto\">\u201epravd\u011bpodobn\u011b jsou k dispozici pouze elektronick\u00e1 data o sekvenci viru\u201c,<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">a pou\u017eit\u00ed:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">&#8222;v\u00fdsledky model\u016f TA1 in silico&#8220;<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">ehm:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><em><span dir=\"auto\">\u201e\u0159\u00eddit v\u00fdvoj preventivn\u00edch metod\u201c.<\/span><\/em><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">A\u0165 u\u017e si \u010dten\u00e1\u0159i z t\u011bchto fakt\u016f vyvod\u00ed jak\u00e9koli z\u00e1v\u011bry, samotn\u00e9 dokumenty DARPA odhaluj\u00ed pozoruhodn\u011b konzistentn\u00ed sled ud\u00e1lost\u00ed:<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Zaprv\u00e9, p\u0159edpov\u011b\u010f.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Za druh\u00e9: preventivn\u00ed n\u00e1vrh.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Za t\u0159et\u00ed: monitorov\u00e1n\u00ed a validace.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Za \u010dtvrt\u00e9: Nasazen\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Mo\u017en\u00e1 nejd\u016fle\u017eit\u011bj\u0161\u00ed ot\u00e1zkou nen\u00ed, odkud p\u0159ijde dal\u0161\u00ed pandemie.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Dalo by se to formulovat takto: Kdo ovl\u00e1d\u00e1 informa\u010dn\u00ed syst\u00e9my, kter\u00e9 ur\u010duj\u00ed, jak\u00e1 bude dal\u0161\u00ed pandemie?<\/span><\/p>\n<p class=\"wp-block-paragraph\"><strong><em><span dir=\"auto\">Od Jona Fleetwooda<\/span><\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/jonfleetwood.substack.com\/p\/beyond-lab-leak-and-natural-spillover\" target=\"_blank\" rel=\"nofollow noopener\"><span dir=\"auto\">Zdroj<\/span><\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>T\u0159et\u00ed p\u0159\u00edstup k pochopen\u00ed modern\u00edch pandemi\u00ed Debata o p\u016fvodu COVID-19 se ji\u017e v\u00edce ne\u017e p\u011bt&#8230;<\/p>\n","protected":false},"author":2,"featured_media":111333,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1042,8341,259],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/111332"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=111332"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/111332\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/111333"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=111332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=111332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=111332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}