{"id":111262,"date":"2026-07-22T00:14:57","date_gmt":"2026-07-21T22:14:57","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=111262"},"modified":"2026-07-21T11:49:33","modified_gmt":"2026-07-21T09:49:33","slug":"spolecnost-moderna-poprve-aplikuje-experimentalni-vakcinu-proti-rakovine-mrna-4200","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/07\/22\/spolecnost-moderna-poprve-aplikuje-experimentalni-vakcinu-proti-rakovine-mrna-4200\/","title":{"rendered":"Spole\u010dnost Moderna poprv\u00e9 aplikuje experiment\u00e1ln\u00ed vakc\u00ednu proti rakovin\u011b \u201emRNA-4200\u201c…"},"content":{"rendered":"
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…kter\u00e1 je navr\u017eena tak, aby stimulovala t\u011blo k produkci sedmi dosud nezve\u0159ejn\u011bn\u00fdch n\u00e1dorov\u00fdch protein\u016f<\/span><\/h3>\n
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Otev\u0159en\u00e9 ot\u00e1zky z\u016fst\u00e1vaj\u00ed ohledn\u011b dlouhodob\u00e9 exprese, p\u0159enosu slo\u017eek vakc\u00edny na jin\u00e9 jedince prost\u0159ednictv\u00edm exosom\u016f a extracelul\u00e1rn\u00edch vezikul a toho, co je \u00fa\u010dastn\u00edk\u016fm sd\u011bleno p\u0159ed \u00fa\u010dast\u00ed.<\/span><\/strong><\/p>\n

Spole\u010dnost Moderna ve \u010dtvrtek\u00a0<\/span>ozn\u00e1mila<\/span><\/a>\u00a0, \u017ee prvn\u00edmu \u00fa\u010dastn\u00edkovi klinick\u00e9 studie f\u00e1ze 1 podala injekci s mRNA-4200 (\u00a0<\/span>NCT06880549<\/span><\/a>\u00a0). Jedn\u00e1 se o experiment\u00e1ln\u00ed produkt mRNA, kter\u00fd po pod\u00e1n\u00ed vyvol\u00e1v\u00e1 v t\u011ble produkci sedmi nespecifikovan\u00fdch n\u00e1dorov\u00fdch protein\u016f.<\/span><\/p>\n

Jin\u00fdmi slovy, produkt nejen dod\u00e1v\u00e1 t\u011blu n\u00e1dorov\u00e9 proteiny \u2013 vyu\u017e\u00edv\u00e1 je samotn\u00e9 t\u011blo k jejich produkci.<\/span><\/p>\n

Z\u00e1m\u011brn\u011b.<\/span><\/p>\n

Studie vyvol\u00e1v\u00e1 z\u0159ejm\u00e9 ot\u00e1zky ohledn\u011b bezpe\u010dnosti a informovan\u00e9ho souhlasu: Jak dlouho t\u011blo produkuje \u00fadajn\u011b k\u00f3dovan\u00e9 n\u00e1dorov\u00e9 proteiny, jak\u00e9 by mohly m\u00edt dlouhodob\u00e9 biologick\u00e9 \u00fa\u010dinky a zda by produkt nebo jeho metabolity mohly b\u00fdt p\u0159eneseny z p\u016fvodn\u00edho p\u0159\u00edjemce na jin\u00e9 osoby prost\u0159ednictv\u00edm exosom\u016f nebo extracelul\u00e1rn\u00edch vezikul ve vylu\u010dovan\u00fdch t\u011bln\u00edch tekutin\u00e1ch.<\/span><\/p>\n

Studie z roku 2021 publikovan\u00e1 v\u00a0<\/span>\u010dasopise Journal of Extracellular Vesicles<\/span><\/a><\/em>\u00a0zjistila, \u017ee bu\u0148ky exprimuj\u00edc\u00ed c\u00edlov\u00fd protein mohou uvol\u0148ovat extracelul\u00e1rn\u00ed vezikuly, kter\u00e9 tento protein \u201etransportuj\u00ed\u201c, co\u017e ukazuje, \u017ee to, co se produkuje v t\u011ble, m\u016f\u017ee b\u00fdt transportov\u00e1no z bu\u0148ky v membr\u00e1nov\u011b v\u00e1zan\u00fdch \u010d\u00e1stic\u00edch.<\/span><\/p>\n

Samostatn\u00fd recenzn\u00ed \u010dl\u00e1nek z roku 2023 v\u00a0<\/span>\u010dasopise Pharmaceutics<\/span><\/a><\/em>\u00a0vysv\u011btluje, \u017ee exosomy jsou p\u0159irozen\u00e9 transportn\u00ed vezikuly, kter\u00e9 p\u0159en\u00e1\u0161ej\u00ed proteiny a nukleov\u00e9 kyseliny po cel\u00e9m t\u011ble a nach\u00e1zej\u00ed se v t\u011bln\u00edch tekutin\u00e1ch, jako je krev, sliny a dal\u0161\u00ed sekrety \u2013 co\u017e znamen\u00e1, \u017ee nejsou omezeny na p\u016fvodn\u00ed bu\u0148ku ani na p\u016fvodn\u00ed um\u00edst\u011bn\u00ed v t\u011ble.<\/span><\/p>\n

M\u016f\u017eete\u00a0kontaktovat\u00a0<\/span>Modernu zde<\/span><\/a>\u00a0a\u00a0<\/span>FDA zde .<\/span><\/a><\/p>\n

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Spole\u010dnost uv\u00e1d\u00ed, \u017ee produkt zkoum\u00e1 u pacient\u016f s pokro\u010dil\u00fdmi solidn\u00edmi n\u00e1dory, v\u010detn\u011b melanomu, nemalobun\u011b\u010dn\u00e9ho karcinomu plic, rakoviny j\u00edcnu, rakoviny \u017ealudku, rakoviny vaje\u010dn\u00edk\u016f, rakoviny d\u011blo\u017en\u00edho \u010d\u00edpku, rakoviny endometria, rakoviny mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e a rakoviny tlust\u00e9ho st\u0159eva.<\/span><\/p>\n

\u00da\u010dastn\u00edci dost\u00e1vaj\u00ed injekce bu\u010f samostatn\u011b, nebo v kombinaci s pembrolizumabem, monoklon\u00e1ln\u00ed protil\u00e1tkou\u00a0prod\u00e1vanou pod n\u00e1zvem\u00a0<\/span>Keytruda .<\/span><\/a><\/p>\n

Na rozd\u00edl od \u201epersonalizovan\u00fdch\u201c program\u016f o\u010dkov\u00e1n\u00ed proti rakovin\u011b od Moderny, kter\u00e9 jsou \u00fadajn\u011b p\u0159izp\u016fsobeny charakteristik\u00e1m n\u00e1doru u jednotliv\u00fdch pacient\u016f, je mRNA-4200 popisov\u00e1na jako \u201estandardn\u00ed produkt\u201c ur\u010den\u00fd k pou\u017eit\u00ed u r\u016fzn\u00fdch druh\u016f rakoviny.<\/span><\/p>\n

Podle ve\u0159ejn\u00fdch prohl\u00e1\u0161en\u00ed spole\u010dnosti Moderna produkt funguje tak, \u017ee po injekci dod\u00e1v\u00e1 instrukce mRNA, kter\u00e9 vedou k produkci sedmi b\u011b\u017en\u00fdch n\u00e1dorov\u00fdch protein\u016f v t\u011ble.<\/span><\/p>\n

V\u00a0<\/span>tiskov\u00e9 zpr\u00e1v\u011b<\/span><\/a>\u00a0se uv\u00e1d\u00ed:<\/span><\/p>\n

\u201eSpole\u010dnost Moderna, Inc. (NASDAQ:MRNA) dnes ozn\u00e1mila, \u017ee prvn\u00ed americk\u00fd \u00fa\u010dastn\u00edk f\u00e1ze 1 klinick\u00e9 studie hodnot\u00edc\u00ed mRNA-4200, kandid\u00e1ta na antigenn\u00ed terapii zam\u011b\u0159enou na n\u00e1dor, obdr\u017eel svou prvn\u00ed d\u00e1vku u pacient\u016f s pokro\u010dil\u00fdmi nebo metastatick\u00fdmi solidn\u00edmi n\u00e1dory. mRNA-4200 k\u00f3duje sedm antigen\u016f, kter\u00e9 se b\u011b\u017en\u011b vyskytuj\u00ed spole\u010dn\u011b u pacient\u016f a typ\u016f n\u00e1dor\u016f, a je navr\u017eena tak, aby pomohla indukovat a zes\u00edlit odpov\u011b\u010f T-bun\u011bk proti vybran\u00fdm c\u00edlov\u00fdm n\u00e1dor\u016fm.\u201c<\/span><\/em><\/p>\n

Moderna v\u0161ak ve\u0159ejn\u011b nezve\u0159ejnila identitu t\u011bchto protein\u016f.<\/span><\/p>\n

Proto v sou\u010dasn\u00e9 dob\u011b nejsme schopni nez\u00e1visle posoudit, kter\u00e9 proteiny jsou produkov\u00e1ny, zda se jedn\u00e1 o kompletn\u00ed proteiny nebo fragmenty, zda se vyskytuj\u00ed v jin\u00fdch \u010d\u00e1stech t\u011bla nebo jak\u00e9 biologick\u00e9 \u00fa\u010dinky by mohly b\u00fdt spojeny s jejich expres\u00ed.<\/span><\/p>\n

O\u010dek\u00e1v\u00e1 se, \u017ee studie zahrne p\u0159ibli\u017en\u011b 42 \u00fa\u010dastn\u00edk\u016f; bude prob\u00edhat na pracovi\u0161t\u00edch v Michiganu, Texasu a Utahu.<\/span><\/p>\n

Dal\u0161\u00ed l\u00e9ky proti rakovin\u011b od spole\u010dnosti Moderna\u00a0<\/span>k\u00f3duj\u00ed<\/span><\/a>\u00a0imunitn\u00ed sign\u00e1ln\u00ed proteiny, jako jsou OX40L, IL-23 a IL-36\u03b3, a byly tak\u00e9 kombinov\u00e1ny s monoklon\u00e1ln\u00edmi protil\u00e1tkami, kter\u00e9 c\u00edl\u00ed na sign\u00e1ln\u00ed dr\u00e1hy imunitn\u00edch kontroln\u00edch bod\u016f.<\/span><\/p>\n

Z\u00e1v\u011br<\/span><\/strong><\/h3>\n

Experiment\u00e1ln\u00ed produkt, kter\u00fd zp\u016fsobuje, \u017ee t\u011blo samo v sob\u011b produkuje n\u00e1dorov\u00e9 proteiny, nyn\u00ed vstoupil do f\u00e1ze testov\u00e1n\u00ed na lidech.<\/span><\/p>\n

\u017d\u00e1dn\u00e9 proteiny se nepod\u00e1vaj\u00ed z ampule.<\/span><\/p>\n

\u017d\u00e1dn\u00e9 proteiny, kter\u00e9 se vyr\u00e1b\u011bj\u00ed v laborato\u0159i.<\/span><\/p>\n

B\u00edlkoviny, kter\u00e9 si p\u0159\u00edjemce vytv\u00e1\u0159\u00ed ve vlastn\u00edm t\u011ble.<\/span><\/p>\n

Z\u00e1m\u011brn\u011b.<\/span><\/p>\n

Moderna uv\u00e1d\u00ed, \u017ee jich je sedm.<\/span><\/p>\n

Spole\u010dnost ve\u0159ejn\u011b nezve\u0159ejnila, o kter\u00e9 se jedn\u00e1.<\/span><\/p>\n

To vyvol\u00e1v\u00e1 ot\u00e1zky, kter\u00e9 by m\u011bly b\u00fdt ve skute\u010dnosti samoz\u0159ejm\u00e9.<\/span><\/p>\n