{"id":110892,"date":"2026-07-17T00:16:02","date_gmt":"2026-07-16T22:16:02","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=110892"},"modified":"2026-07-16T12:29:04","modified_gmt":"2026-07-16T10:29:04","slug":"strasi-vas-lekar-vysokym-homocysteinem-pozor-jeho-prilisne-snizeni-muze-byt-jeste-zaludnejsi","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/07\/17\/strasi-vas-lekar-vysokym-homocysteinem-pozor-jeho-prilisne-snizeni-muze-byt-jeste-zaludnejsi\/","title":{"rendered":"Stra\u0161\u00ed v\u00e1s l\u00e9ka\u0159 vysok\u00fdm homocysteinem? Pozor, jeho p\u0159\u00edli\u0161n\u00e9 sn\u00ed\u017een\u00ed m\u016f\u017ee b\u00fdt je\u0161t\u011b z\u00e1ludn\u011bj\u0161\u00ed!"},"content":{"rendered":"
<\/div>\n

\u010c\u00edm n\u00ed\u017ee, t\u00edm l\u00e9pe? Co si p\u0159edstav\u00edte, kdy\u017e usly\u0161\u00edte slovo\u00a0<\/span>homocystein<\/span><\/strong>\u00a0? Pravd\u011bpodobn\u011b n\u011bco negativn\u00edho. Vy\u0161\u0161\u00ed riziko srde\u010dn\u011b-c\u00e9vn\u00edch onemocn\u011bn\u00ed. Po\u0161kozen\u00ed c\u00e9v. Toxick\u00e1 l\u00e1tka, kter\u00e9 by m\u011blo b\u00fdt v t\u011ble co nejm\u00e9n\u011b.<\/span><\/p>\n

J\u00e1 se na homocystein d\u00edv\u00e1m trochu jinak. Na\u0161e t\u011blo si jej nevyr\u00e1b\u00ed n\u00e1hodou.<\/span><\/p>\n

Homocystein nen\u00ed odpadn\u00ed ani toxick\u00e1 l\u00e1tka. Je p\u0159irozenou sou\u010d\u00e1st\u00ed metabolismu a d\u016fle\u017eit\u00fdm meziproduktem p\u0159i tvorb\u011b v\u00edce l\u00e1tek pot\u0159ebn\u00fdch pro spr\u00e1vn\u00e9 fungov\u00e1n\u00ed organismu.<\/span><\/p>\n

Proto si nemysl\u00edm, \u017ee c\u00edlem je dostat jeho hladinu co nejn\u00ed\u017ee. D\u016fle\u017eit\u00e1 je p\u0159edev\u0161\u00edm rovnov\u00e1ha.<\/span><\/p>\n

Pro\u010d se o n\u00edzk\u00e9m homocysteinu t\u00e9m\u011b\u0159 nemluv\u00ed?<\/span><\/h2>\n

Kdy jste naposledy sly\u0161eli l\u00e9ka\u0159e \u0159\u00edct:\u00a0<\/span>„M\u00e1te p\u0159\u00edli\u0161 n\u00edzk\u00fd homocystein. Zkusme zjistit, pro\u010d.“<\/span><\/em><\/p>\n

J\u00e1 t\u00e9m\u011b\u0159 nikdy.<\/span><\/p>\n

Nen\u00ed to p\u0159ekvapuj\u00edc\u00ed. V\u011bt\u0161ina v\u00fdzkum\u016f i odborn\u00fdch diskus\u00ed se soust\u0159e\u010fuje na zv\u00fd\u0161en\u00fd homocystein, jeho\u017e souvislost s v\u00edce onemocn\u011bn\u00edmi zkoumaj\u00ed tis\u00edce v\u011bdeck\u00fdch prac\u00ed.<\/span><\/p>\n

Ze zv\u011bdavosti jsem proto vyhledal publikace o n\u00edzk\u00e9m homocysteinu pod odborn\u00fdm n\u00e1zvem\u00a0<\/span>hypohomocysteinemie<\/span><\/strong>\u00a0.<\/span><\/p>\n

V\u00fdsledek m\u011b p\u0159ekvapil. Na\u0161el jsem jen n\u011bkolik prac\u00ed, zat\u00edmco studi\u00ed o zv\u00fd\u0161en\u00e9m homocysteinu existuj\u00ed tis\u00edce.<\/span><\/p>\n

To samo o sob\u011b je\u0161t\u011b neznamen\u00e1, \u017ee n\u00edzk\u00fd homocystein p\u0159edstavuje zdravotn\u00ed probl\u00e9m. Nazna\u010duje to v\u0161ak, \u017ee t\u00e9to oblasti se zat\u00edm v\u011bnovalo jen velmi m\u00e1lo pozornosti.<\/span><\/p>\n

Ot\u00e1zka, na kterou zat\u00edm nezn\u00e1me odpov\u011b\u010f<\/span><\/h2>\n

Jedna z m\u00e1la publikovan\u00fdch prac\u00ed popisovala souvislost mezi hypohomocysteinemi\u00ed a idiopatickou perifern\u00ed neuropati\u00ed.<\/span><\/p>\n

To ve mn\u011b vyvolalo ot\u00e1zku.<\/span><\/p>\n

Homocystein se pod\u00edl\u00ed na tvorb\u011b cysteinu, ze kter\u00e9ho si organismus vytv\u00e1\u0159\u00ed glutathion \u2013 jeden z nejd\u016fle\u017eit\u011bj\u0161\u00edch nitrobun\u011b\u010dn\u00fdch antioxidant\u016f.<\/span><\/p>\n

Pokud je homocysteinu dlouhodob\u011b velmi m\u00e1lo, teoreticky by to za ur\u010dit\u00fdch okolnost\u00ed mohlo ovlivnit i tvorbu glutathionu. Zat\u00edm v\u0161ak jde sp\u00ed\u0161e o biologicky smysluplnou hypot\u00e9zu ne\u017e o potvrzen\u00fd mechanismus.<\/span><\/p>\n

Pr\u00e1v\u011b proto si mysl\u00edm, \u017ee velmi n\u00edzk\u00fd homocystein si zaslou\u017e\u00ed v\u00edce pozornosti, ne\u017e se mu dnes v\u011bnuje.<\/span><\/p>\n

Paradox p\u0159i diabetu 1. typu<\/span><\/h2>\n

V\u00fdzkum n\u00edzk\u00e9ho homocysteinu je zat\u00edm v plenk\u00e1ch. Zaujala m\u011b nap\u0159\u00edklad studie u d\u011bt\u00ed s diabetem 1. typu. Auto\u0159i zjistili, \u017ee m\u011bli ni\u017e\u0161\u00ed hladiny homocysteinu ne\u017e zdrav\u00e9 d\u011bti, a\u010dkoli jejich dlouhodob\u00e9 riziko srde\u010dn\u011b-c\u00e9vn\u00edch onemocn\u011bn\u00ed je vy\u0161\u0161\u00ed. Sami tento v\u00fdsledek ozna\u010dili za paradox.<\/span><\/p>\n

Napadla m\u011b p\u0159itom jin\u00e1 ot\u00e1zka.<\/span><\/p>\n

Diabetes 1. typu b\u00fdv\u00e1 spojen se zv\u00fd\u0161en\u00fdm oxida\u010dn\u00edm stresem a organismus se proti n\u011bmu br\u00e1n\u00ed mimo jin\u00e9 pomoc\u00ed glutathionu. Jeliko\u017e homocystein pat\u0159\u00ed do metabolick\u00fdch drah vedouc\u00edch k jeho tvorb\u011b, napadlo m\u011b, zda ni\u017e\u0161\u00ed hladina homocysteinu u n\u011bkter\u00fdch lid\u00ed neodr\u00e1\u017e\u00ed jeho intenzivn\u011bj\u0161\u00ed vyu\u017e\u00edv\u00e1n\u00ed.<\/span><\/p>\n

Zd\u016fraz\u0148uji v\u0161ak, \u017ee jde jen o \u00favahu. Z dostupn\u00fdch \u00fadaj\u016f nelze vyvodit, \u017ee pr\u00e1v\u011b zv\u00fd\u0161en\u00e1 tvorba glutathionu vysv\u011btluje ni\u017e\u0161\u00ed homocystein p\u0159i diabetu.<\/span><\/p>\n

Pokud bych to velmi zjednodu\u0161il, uva\u017euji nad t\u00edmto vztahem:<\/span><\/p>\n

vy\u0161\u0161\u00ed oxida\u010dn\u00ed stres \u2192 vy\u0161\u0161\u00ed pot\u0159eba glutathionu \u2192 vy\u0161\u0161\u00ed n\u00e1roky na metabolick\u00e9 dr\u00e1hy, kter\u00e9 se pod\u00edlej\u00ed na jeho tvorb\u011b<\/span><\/strong><\/p>\n

To ov\u0161em neznamen\u00e1, \u017ee ka\u017ed\u00fd \u010dlov\u011bk s n\u00edzk\u00fdm homocysteinem m\u00e1 nedostatek glutathionu. Hladinu homocysteinu ovliv\u0148uje cel\u00e1 \u0159ada faktor\u016f.<\/span><\/p>\n

Norm\u00e1ln\u00ed hladina homocysteinu<\/span><\/h2>\n

Velk\u00e1 \u010d\u00e1st v\u00fdzkum\u016f nazna\u010duje, \u017ee z hlediska srde\u010dn\u011b-c\u00e9vn\u00edho zdrav\u00ed jsou p\u0159\u00edzniv\u00e9 hodnoty p\u0159ibli\u017en\u011b mezi\u00a0<\/span>6 a\u017e 8 \u00b5mol\/l<\/span><\/strong>\u00a0. O tom, zda existuje doln\u00ed hranice, pod kterou za\u010d\u00ednaj\u00ed p\u0159eva\u017eovat nev\u00fdhody, zat\u00edm v\u00edme velmi m\u00e1lo.<\/span><\/p>\n

Homocystein v\u0161ak nen\u00ed d\u016fle\u017eit\u00fd jen pro zdrav\u00ed srdce a c\u00e9v. Je sou\u010d\u00e1st\u00ed metabolick\u00fdch d\u011bj\u016f vedouc\u00edch k tvorb\u011b\u00a0<\/span>SAMe (S-adenosylmethioninu)<\/span><\/strong> \u2013 hlavn\u00edho donoru metylov\u00fdch skupin \u2013 a z\u00e1rove\u0148 se pod\u00edl\u00ed na tvorb\u011b cysteinu, ze kter\u00e9ho vznik\u00e1 glutathion.<\/span><\/p>\n

Proto si mysl\u00edm, \u017ee p\u0159i hodnocen\u00ed homocysteinu bychom se nem\u011bli pt\u00e1t jen:\u00a0<\/span>\u201e\u00a0<\/span><\/em><\/strong>Je dostate\u010dn\u011b n\u00edzk\u00fd?\u00a0<\/span><\/em><\/strong>\u201c<\/span><\/em><\/strong><\/p>\n

Stejn\u011b d\u016fle\u017eit\u00e1 ot\u00e1zka zn\u00ed:\u00a0<\/span>“\u00a0<\/span><\/em><\/strong>Je jeho hladina p\u0159im\u011b\u0159en\u00e1 tomu, co organismus pr\u00e1v\u011b pot\u0159ebuje?\u00a0<\/span><\/em><\/strong>„<\/span><\/em><\/strong><\/p>\n

Samotn\u00e1 ni\u017e\u0161\u00ed hladina homocysteinu p\u0159itom neznamen\u00e1, \u017ee organismus vytv\u00e1\u0159\u00ed v\u00edce glutathionu. Takov\u00fd vztah zat\u00edm nebyl jednozna\u010dn\u011b potvrzen.<\/span><\/p>\n

Co podle m\u011b pat\u0159\u00ed mezi mo\u017en\u00e9 p\u0159\u00ed\u010diny n\u00edzk\u00e9ho homocysteinu<\/span><\/h2>\n

Neexistuje jedin\u00e1 univerz\u00e1ln\u00ed odpov\u011b\u010f. Hladinu homocysteinu ovliv\u0148uje n\u011bkolik faktor\u016f a \u010dasto jde o jejich kombinaci.<\/span><\/p>\n

1. Intenzivn\u00ed podpora metylace<\/span><\/h3>\n

Vitam\u00edny B6, B12 a fol\u00e1t pat\u0159\u00ed mezi hlavn\u00ed \u017eiviny zapojen\u00e9 do metabolismu homocysteinu.<\/span><\/p>\n

P\u0159i vysok\u00fdch d\u00e1vk\u00e1ch t\u011bchto vitam\u00edn\u016f nebo jin\u00fdch l\u00e1tek podporuj\u00edc\u00edch metylaci m\u016f\u017ee hladina homocysteinu v\u00fdrazn\u011b klesnout.<\/span><\/p>\n

Samo o sob\u011b to je\u0161t\u011b nemus\u00ed p\u0159edstavovat probl\u00e9m. Pokud v\u0161ak laboratorn\u00ed hodnota klesne neobvykle n\u00edzko nebo se objev\u00ed pot\u00ed\u017ee, stoj\u00ed za zv\u00e1\u017een\u00ed p\u0159ehodnotit suplementaci spolu s l\u00e9ka\u0159em nebo zku\u0161en\u00fdm odborn\u00edkem.<\/span><\/p>\n

2. N\u00edzk\u00fd p\u0159\u00edjem b\u00edlkovin<\/span><\/h3>\n

Homocystein vznik\u00e1 p\u0159i metabolismu aminokyseliny methionin, kterou p\u0159ij\u00edm\u00e1me ze stravy.<\/span><\/p>\n

Pokud je p\u0159\u00edjem b\u00edlkovin dlouhodob\u011b velmi n\u00edzk\u00fd, m\u016f\u017ee se to odrazit i na jeho hladin\u011b. To ov\u0161em neznamen\u00e1, \u017ee ka\u017ed\u00fd \u010dlov\u011bk s n\u00edzk\u00fdm homocysteinem p\u0159ij\u00edm\u00e1 m\u00e1lo b\u00edlkovin.<\/span><\/p>\n

Obecn\u011b m\u00e1 smysl db\u00e1t na p\u0159im\u011b\u0159en\u00fd p\u0159\u00edjem kvalitn\u00edch b\u00edlkovin podle v\u011bku, zdravotn\u00edho stavu a \u00farovn\u011b fyzick\u00e9 aktivity.<\/span><\/p>\n

3. Vy\u0161\u0161\u00ed pot\u0159eba glutathionu<\/span><\/h3>\n

Homocystein se pod\u00edl\u00ed na tvorb\u011b cysteinu, ze kter\u00e9ho vznik\u00e1 glutathion.<\/span><\/p>\n

P\u0159i vy\u0161\u0161\u00edm oxida\u010dn\u00edm stresu nebo chronick\u00e9m z\u00e1n\u011btu organismus glutathion spot\u0159ebov\u00e1v\u00e1 ve v\u011bt\u0161\u00edm mno\u017estv\u00ed. Je proto logick\u00e9 uva\u017eovat nad t\u00edm, zda se za ur\u010dit\u00fdch okolnost\u00ed nem\u011bn\u00ed i tok l\u00e1tek v t\u011bchto metabolick\u00fdch drah\u00e1ch.<\/span><\/p>\n

Zat\u00edm v\u0161ak nem\u00e1me dostatek d\u016fkaz\u016f, abychom tento mechanismus pova\u017eovali za hlavn\u00ed p\u0159\u00ed\u010dinu n\u00edzk\u00e9ho homocysteinu.<\/span><\/p>\n

Mnohem v\u011bt\u0161\u00ed smysl m\u00e1 hledat p\u0159\u00ed\u010diny zv\u00fd\u0161en\u00e9ho oxida\u010dn\u00edho stresu \u2013 nap\u0159\u00edklad\u00a0<\/span>nedostatek sp\u00e1nku<\/span><\/a>\u00a0, chronick\u00fd stres, kou\u0159en\u00ed, nadm\u011brnou konzumaci alkoholu nebo dlouhodob\u00e1 z\u00e1n\u011btliv\u00e1 onemocn\u011bn\u00ed.<\/span><\/p>\n

4. Hor\u0161\u00ed tr\u00e1ven\u00ed a vst\u0159eb\u00e1v\u00e1n\u00ed \u017eivin<\/span><\/h3>\n

Nesta\u010d\u00ed p\u0159ijmout dostatek b\u00edlkovin. Organismus je mus\u00ed um\u011bt i rozlo\u017eit a vyu\u017e\u00edt.<\/span><\/p>\n

N\u011bkter\u00e1 onemocn\u011bn\u00ed tr\u00e1vic\u00edho traktu, poruchy vst\u0159eb\u00e1v\u00e1n\u00ed nebo dlouhodob\u00e9 u\u017e\u00edv\u00e1n\u00ed l\u00e9k\u016f sni\u017euj\u00edc\u00edch tvorbu \u017ealude\u010dn\u00ed kyseliny mohou ovlivnit vyu\u017eit\u00ed b\u00edlkovin i vitam\u00edn\u016f skupiny B, kter\u00e9 hraj\u00ed v metabolismu homocysteinu v\u00fdznamnou roli.<\/span><\/p>\n

Kdo se je\u0161t\u011b d\u00edv\u00e1 na n\u00edzk\u00fd homocystein podobn\u011b?<\/span><\/h2>\n

Kdy\u017e jsem se za\u010dal tomuto t\u00e9matu v\u011bnovat, zaj\u00edmalo m\u011b, jestli jsem jedin\u00fd, komu se zd\u00e1 zvl\u00e1\u0161tn\u00ed, \u017ee o velmi n\u00edzk\u00e9m homocysteinu se prakticky nemluv\u00ed.<\/span><\/p>\n

P\u0159i hled\u00e1n\u00ed odborn\u00e9 literatury jsem narazil i na \u010dl\u00e1nek naturopatick\u00e9ho l\u00e9ka\u0159e Josepha Pizzorna, jednoho ze spoluzakladatel\u016f Bastyr University, s provokativn\u00edm n\u00e1zvem\u00a0<\/span>\u201eHomocystein: p\u0159\u00edtel nebo nep\u0159\u00edtel?\u201c<\/span><\/strong><\/p>\n

Nazna\u010duje toti\u017e, \u017ee biologick\u00e9 l\u00e1tky jen z\u0159\u00eddka b\u00fdvaj\u00ed v\u00fdlu\u010dn\u011b \u201edobr\u00e9\u201c nebo \u201e\u0161patn\u00e9\u201c. Jejich v\u00fdznam z\u00e1vis\u00ed na mno\u017estv\u00ed, okolnostech a celkov\u00e9m stavu organismu.<\/span><\/p>\n

Podobn\u011b se d\u00edv\u00e1m i na homocystein.<\/span><\/p>\n

Nep\u0159esv\u011bd\u010duji v\u00e1s, \u017ee vysok\u00e9 hodnoty jsou v po\u0159\u00e1dku. Naopak existuje \u0159ada kvalitn\u00edch studi\u00ed, kter\u00e9 je spojuj\u00ed s vy\u0161\u0161\u00edm rizikem v\u00edce onemocn\u011bn\u00ed. To nelze ignorovat.<\/span><\/p>\n

Z\u00e1rove\u0148 jsem p\u0159esv\u011bd\u010den, \u017ee ani opa\u010dn\u00fd extr\u00e9m bychom nem\u011bli automaticky pova\u017eovat za ide\u00e1ln\u00ed jen proto, \u017ee o n\u011bm zat\u00edm v\u00edme m\u00e1lo. Nedostatek v\u00fdzkumu toti\u017e neznamen\u00e1, \u017ee probl\u00e9m neexistuje. Znamen\u00e1 jen, \u017ee zat\u00edm nem\u00e1me dostatek odpov\u011bd\u00ed.<\/span><\/p>\n

Byl bych proto r\u00e1d, kdyby se budouc\u00ed v\u00fdzkum nezab\u00fdval jen ot\u00e1zkou, jak homocystein sni\u017eovat, ale tak\u00e9 t\u00edm, jak\u00e9 d\u016fsledky m\u00e1 jeho dlouhodob\u011b velmi n\u00edzk\u00e1 hladina a kde se ve skute\u010dnosti nach\u00e1z\u00ed jeho optim\u00e1ln\u00ed rozmez\u00ed.<\/span><\/p>\n

Pr\u00e1v\u011b to pova\u017euji za mnohem zaj\u00edmav\u011bj\u0161\u00ed ot\u00e1zku ne\u017e pouh\u00e9 p\u0159esv\u011bd\u010den\u00ed, \u017ee\u00a0<\/span>\u010d\u00edm ni\u017e\u0161\u00ed, t\u00edm l\u00e9pe.<\/span><\/strong><\/p>\n

Z\u00e1v\u011br<\/span><\/h2>\n

Pokud v\u00e1m l\u00e9ka\u0159 p\u0159i vy\u0161et\u0159en\u00ed zjist\u00ed sn\u00ed\u017eenou nebo zv\u00fd\u0161enou hladinu homocysteinu, nemus\u00ed to automaticky znamenat zdravotn\u00ed probl\u00e9m.<\/span><\/p>\n

Je rozumn\u00e9 pod\u00edvat se na v\u00fdsledek v souvislosti s celkov\u00fdm zdravotn\u00edm stavem, v\u00fd\u017eivou, u\u017e\u00edvan\u00fdmi dopl\u0148ky a dal\u0161\u00edmi laboratorn\u00edmi parametry.<\/span><\/p>\n

Zdroj:\u00a0<\/span>drbenlynch.com<\/span><\/a><\/p>\n

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\u010c\u00edm n\u00ed\u017ee, t\u00edm l\u00e9pe? Co si p\u0159edstav\u00edte, kdy\u017e usly\u0161\u00edte slovo\u00a0homocystein\u00a0? Pravd\u011bpodobn\u011b n\u011bco negativn\u00edho. Vy\u0161\u0161\u00ed riziko…<\/p>\n","protected":false},"author":2,"featured_media":110893,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[11243,630,110,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/110892"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=110892"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/110892\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/110893"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=110892"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=110892"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=110892"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}