{"id":110530,"date":"2026-07-11T00:14:49","date_gmt":"2026-07-10T22:14:49","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=110530"},"modified":"2026-07-10T12:01:42","modified_gmt":"2026-07-10T10:01:42","slug":"zdravy-muz-zemrel-na-toxicky-sok-po-podani-nove-vakciny-proti-ptaci-chripce-s-mrna-1018-od-spolecnosti-moderna","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/07\/11\/zdravy-muz-zemrel-na-toxicky-sok-po-podani-nove-vakciny-proti-ptaci-chripce-s-mrna-1018-od-spolecnosti-moderna\/","title":{"rendered":"Zdrav\u00fd mu\u017e zem\u0159el na toxick\u00fd \u0161ok po pod\u00e1n\u00ed nov\u00e9 vakc\u00edny proti pta\u010d\u00ed ch\u0159ipce s mRNA-1018 od spole\u010dnosti Moderna"},"content":{"rendered":"
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V\u011bdci z Moderny ji\u017e d\u0159\u00edve p\u0159ipustili, \u017ee l\u00e9ky s mRNA vykazuj\u00ed \u201enep\u0159ijatelnou \u00farove\u0148 toxicity\u201c, p\u0159i\u010dem\u017e LNP z Moderny se hromad\u00ed v j\u00e1trech, slezin\u011b, plazm\u011b (krvi), ledvin\u00e1ch, srdci a plic\u00edch savc\u016f.<\/span><\/strong><\/p>\n

Zdrav\u00fd 74let\u00fd mu\u017e zem\u0159el na syndrom toxick\u00e9ho \u0161oku b\u011bhem klinick\u00e9 studie f\u00e1ze 1\/2 experiment\u00e1ln\u00ed vakc\u00edny proti pandemick\u00e9 ch\u0159ipce mRNA-1018, kterou provedla spole\u010dnost Moderna. Odhalila to studie publikovan\u00e1 v dubnu v \u010dasopise\u00a0<\/span>Clinical Infectious Diseases<\/span><\/em>\u00a0v\u011bdci z Moderny a spolupracuj\u00edc\u00edch instituc\u00ed.<\/span><\/p>\n

V\u011bdci z Moderny a spolupracuj\u00edc\u00edch instituc\u00ed tvrd\u00ed, \u017ee \u00famrt\u00ed nesouvis\u00ed s o\u010dkov\u00e1n\u00edm Modernou, ani\u017e by v\u0161ak vysv\u011btlili, jak k tomuto zji\u0161t\u011bn\u00ed dosp\u011bli.<\/span><\/p>\n

V\u00fdsledky jsou zve\u0159ejn\u011bny v dob\u011b, kdy Moderna pokra\u010duje ve v\u00fdvoji sv\u00e9 vakc\u00edny mRNA-1018 proti pandemii pta\u010d\u00ed ch\u0159ipky s podporou a\u017e 54,3 milionu dolar\u016f od Koalice pro inovace v p\u0159ipravenosti na epidemie (CEPI), podporovan\u00e9 Billem Gatesem, pot\u00e9, co americk\u00e9 ministerstvo zdravotnictv\u00ed a soci\u00e1ln\u00edch slu\u017eeb ukon\u010dilo p\u0159edchoz\u00ed financov\u00e1n\u00ed programu.<\/span><\/p>\n

\u010cl\u00e1nek publikovan\u00fd v lednu 2023 v\u00a0<\/span>\u010dasopise Nature Reviews Drug Discovery<\/span><\/em>\u00a0, jeho\u017e spoluautory jsou v\u011bdci z Moderny, otev\u0159en\u011b p\u0159izn\u00e1v\u00e1, \u017ee vyhnut\u00ed se \u201enep\u0159ijateln\u00e9 toxicit\u011b\u201c u mRNA vakc\u00edn z\u016fst\u00e1v\u00e1 velkou v\u00fdzvou, a varuje, \u017ee \u201estruktur\u00e1ln\u00ed slo\u017eky lipidov\u00fdch nano\u010d\u00e1stic, v\u00fdrobn\u00ed procesy, cesty pod\u00e1n\u00ed a proteiny produkovan\u00e9 z komplexn\u00edch mRNA vzbuzuj\u00ed obavy ohledn\u011b toxicity\u201c a \u017ee zp\u016fsob, jak\u00fdm se tyto vakc\u00edny \u0161\u00ed\u0159\u00ed v t\u011ble, m\u016f\u017ee zp\u016fsobit po\u0161kozen\u00ed v d\u016fsledku \u201ebun\u011b\u010dn\u00e9ho tropismu a distribuce v tk\u00e1n\u00edch\u2026 a tak\u00e9 jejich potenci\u00e1ln\u00ed reaktogenity\u201c.<\/span><\/p>\n

V listopadu 2017 spole\u010dnost Moderna p\u0159edstavila data, kter\u00e1 ukazuj\u00ed, \u017ee lipidov\u00e9 nano\u010d\u00e1stice (LNP) jej\u00ed mRNA vakc\u00edny se hromad\u00ed v j\u00e1trech, slezin\u011b, plazm\u011b (krvi), ledvin\u00e1ch, srdci a plic\u00edch savc\u016f.<\/span><\/p>\n

Syndrom toxick\u00e9ho \u0161oku se obvykle p\u0159ipisuje toxin\u016fm produkovan\u00fdm b\u011bhem ur\u010dit\u00fdch bakteri\u00e1ln\u00edch infekc\u00ed, ale \u010dl\u00e1nek poskytuje p\u0159\u00edli\u0161 m\u00e1lo klinick\u00fdch informac\u00ed k nez\u00e1visl\u00e9mu posouzen\u00ed, zda k \u00famrt\u00ed \u00fa\u010dastn\u00edka mohl p\u0159isp\u011bt jin\u00fd mechanismus, jako nap\u0159\u00edklad LNP.<\/span><\/p>\n

Studie zkoumala p\u011bt experiment\u00e1ln\u00edch kandid\u00e1t\u016f na mRNA vakc\u00edny, souhrnn\u011b ozna\u010dovan\u00fdch jako \u201emRNA-1018\u201c, kter\u00e9 m\u011bly chr\u00e1nit p\u0159ed viry ch\u0159ipky A s pandemick\u00fdm potenci\u00e1lem, v\u010detn\u011b H5N1, H5N8 a H7N9.<\/span><\/p>\n

Studie se z\u00fa\u010dastnili pouze zdrav\u00ed dosp\u011bl\u00ed na pracovi\u0161t\u00edch ve Spojen\u00fdch st\u00e1tech a Spojen\u00e9m kr\u00e1lovstv\u00ed; \u00fa\u010dastn\u00edci dostali dv\u011b injekce s odstupem 21 dn\u016f.<\/span><\/p>\n

\u201eZ\u00fa\u010dastnit se mohli zdrav\u00ed dosp\u011bl\u00ed ve v\u011bku 18 let a star\u0161\u00ed,\u201c uv\u00e1d\u00ed publikace.<\/span><\/em><\/p>\n

Podle dopl\u0148uj\u00edc\u00edch \u00fadaj\u016f museli b\u00fdt \u00fa\u010dastn\u00edci klasifikov\u00e1ni jako zdrav\u00ed na z\u00e1klad\u011b jejich anamn\u00e9zy, fyzik\u00e1ln\u00edho vy\u0161et\u0159en\u00ed, laboratorn\u00edch test\u016f a v\u00fdsledk\u016f elektrokardiogramu, zat\u00edmco osoby s nestabiln\u00edm zdravotn\u00edm stavem, imunodeficienc\u00ed, imunitn\u011b zprost\u0159edkovan\u00fdmi onemocn\u011bn\u00edmi nebo v\u00fdznamn\u00fdmi laboratorn\u00edmi abnormalitami byly z \u00fa\u010dasti vylou\u010deny.<\/span><\/p>\n

Vakc\u00edny maj\u00ed obsahovat medi\u00e1torovou RNA zabalenou v lipidov\u00fdch nano\u010d\u00e1stic\u00edch a k\u00f3duj\u00edc\u00ed povrchov\u00e9 proteiny ch\u0159ipky.<\/span><\/p>\n

Vakc\u00edny byly vyrobeny s pou\u017eit\u00edm stejn\u00e9 mRNA platformy, kterou Moderna pou\u017e\u00edv\u00e1 i pro sv\u00e9 schv\u00e1len\u00e9 produkty, jako je vakc\u00edna proti COVID-19.<\/span><\/p>\n

Studie uv\u00e1d\u00ed o \u00famrt\u00ed:<\/span><\/p>\n

\u201eJedno \u00famrt\u00ed (v d\u016fsledku syndromu toxick\u00e9ho \u0161oku), kter\u00e9 bylo klasifikov\u00e1no jako \u00famrt\u00ed nesouvisej\u00edc\u00ed se studovanou vakc\u00ednou, bylo hl\u00e1\u0161eno 139. den u 74let\u00e9ho mu\u017ee, kter\u00fd dostal dv\u011b d\u00e1vky 50 \u00b5g \u010dist\u00e9 vakc\u00edny H7,\u201c napsali auto\u0159i.<\/span><\/em><\/p>\n

Publikace neobsahuje \u017e\u00e1dn\u00e9 dal\u0161\u00ed podrobnosti o tomto smrteln\u00e9m p\u0159\u00edpadu.<\/span><\/p>\n

Neuv\u00e1d\u00ed nejmenov\u00e1n\u00ed patogenu zodpov\u011bdn\u00e9ho za syndrom toxick\u00e9ho \u0161oku, ani neposkytuje informace o tom, zda se u \u00fa\u010dastn\u00edka d\u0159\u00edve rozvinula infekce, neuv\u00e1d\u00ed podrobnosti o pobytu v nemocnici, nediskutuje laboratorn\u00ed n\u00e1lezy, neposkytuje informace o pitv\u011b ani nevysv\u011btluje metodologii, kterou v\u011bdci pou\u017eili k z\u00e1v\u011bru, \u017ee smrt nesouvis\u00ed s o\u010dkov\u00e1n\u00edm.<\/span><\/p>\n

Nedostatek t\u011bchto podrobnost\u00ed znemo\u017e\u0148uje \u010dten\u00e1\u0159\u016fm nez\u00e1visle posoudit smrtelnou ud\u00e1lost nebo posouzen\u00ed kauzality v\u00fdzkumn\u00edky.<\/span><\/p>\n

Vzhledem k tomu, \u017ee \u00fa\u010dastn\u00edk byl do studie za\u0159azen jako zdrav\u00fd dosp\u011bl\u00fd, \u010dl\u00e1nek nastoluje ot\u00e1zky, na kter\u00e9 neodpov\u00edd\u00e1: Nem\u011blo smrteln\u00e9 onemocn\u011bn\u00ed v\u016fbec nic spole\u010dn\u00e9ho s o\u010dkov\u00e1n\u00edm, nebo k n\u011bmu mohla vakc\u00edna p\u0159isp\u011bt neidentifikovan\u00fdm biologick\u00fdm mechanismem?<\/span><\/p>\n

Publikace nezkoum\u00e1, zda samotn\u00e9 slo\u017eky vakc\u00edny, exprese k\u00f3dovan\u00fdch ch\u0159ipkov\u00fdch protein\u016f, po\u0161kozen\u00ed imunitn\u00edho syst\u00e9mu nebo n\u011bjak\u00fd jin\u00fd mechanismus \u00fa\u010dinku sehr\u00e1ly roli v neschopnosti \u00fa\u010dastn\u00edka p\u0159e\u017e\u00edt onemocn\u011bn\u00ed.<\/span><\/p>\n

M\u00edsto toho je uveden pouze z\u00e1v\u011br v\u00fdzkumn\u00edk\u016f, \u017ee \u00famrt\u00ed nesouviselo se studovanou vakc\u00ednou.<\/span><\/p>\n

Krom\u011b \u00famrt\u00ed v\u011bdci b\u011bhem studie hl\u00e1sili i dal\u0161\u00ed z\u00e1va\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky.<\/span><\/p>\n

Publikace uv\u00e1d\u00ed, \u017ee k z\u00e1va\u017en\u00fdm ne\u017e\u00e1douc\u00edm \u00fa\u010dink\u016fm do\u0161lo u 24 \u00fa\u010dastn\u00edk\u016f \u010d\u00e1sti A a u \u010dty\u0159 \u00fa\u010dastn\u00edk\u016f \u010d\u00e1sti B.<\/span><\/p>\n

Z\u00e1va\u017en\u00fd ne\u017e\u00e1douc\u00ed \u00fa\u010dinek, synkopa (mdloby), byl klasifikov\u00e1n jako souvisej\u00edc\u00ed s o\u010dkov\u00e1n\u00edm.<\/span><\/p>\n

V\u00fdzkumn\u00edci tak\u00e9 identifikovali dva p\u0159\u00edpady trombocytopenie (abnorm\u00e1ln\u011b n\u00edzk\u00fd po\u010det krevn\u00edch desti\u010dek, naz\u00fdvan\u00fdch trombocyty, v krvi) souvisej\u00edc\u00ed s o\u010dkov\u00e1n\u00edm a jeden p\u0159\u00edpad akutn\u00ed tyreoiditidy (z\u00e1n\u011btu \u0161t\u00edtn\u00e9 \u017el\u00e1zy) souvisej\u00edc\u00ed s o\u010dkov\u00e1n\u00edm, co\u017e vedlo k odstoupen\u00ed jednoho \u00fa\u010dastn\u00edka ze studie.<\/span><\/p>\n

V\u011bt\u0161ina \u00fa\u010dastn\u00edk\u016f tak\u00e9 po o\u010dkov\u00e1n\u00ed zaznamenala kr\u00e1tkodob\u00e9 reakce.<\/span><\/p>\n

U r\u016fzn\u00fdch kandid\u00e1tn\u00edch vakc\u00edn a d\u00e1vek se o\u010dek\u00e1van\u00e9 lok\u00e1ln\u00ed reakce \u2013 v\u010detn\u011b bolesti v m\u00edst\u011b injekce \u2013 vyskytly u p\u0159ibli\u017en\u011b 70 % a\u017e v\u00edce ne\u017e 90 % \u00fa\u010dastn\u00edk\u016f, zat\u00edmco syst\u00e9mov\u00e9 reakce, jako je \u00fanava a bolest hlavy, se vyskytly u v\u00edce ne\u017e poloviny.<\/span><\/p>\n

Vy\u0161\u0161\u00ed d\u00e1vky obecn\u011b vedly k vy\u0161\u0161\u00ed m\u00ed\u0159e ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f.<\/span><\/p>\n

Z\u00e1v\u011br<\/span><\/strong><\/h2>\n

Studie spole\u010dnosti Moderna uv\u00e1d\u00ed, \u017ee zdrav\u00fd \u00fa\u010dastn\u00edk zem\u0159el na syndrom toxick\u00e9ho \u0161oku po pod\u00e1n\u00ed experiment\u00e1ln\u00ed vakc\u00edny z pta\u010d\u00ed ch\u0159ipky s mRNA-1018; toto \u00famrt\u00ed je v\u0161ak shrnuto v jedin\u00e9 v\u011bt\u011b, ne\u017e jej v\u011bdci klasifikuj\u00ed jako \u00famrt\u00ed nesouvisej\u00edc\u00ed s o\u010dkov\u00e1n\u00edm.<\/span><\/p>\n

Toto opomenut\u00ed je o to v\u00fdznamn\u011bj\u0161\u00ed, \u017ee v\u011bdci z Moderny samostatn\u011b uznali, \u017ee existuj\u00ed potenci\u00e1ln\u00ed obavy ohledn\u011b \u201enep\u0159ijateln\u00e9 toxicity\u201c spojen\u00e9 s mRNA vakc\u00ednami, a to v souvislosti s lipidov\u00fdmi nano\u010d\u00e1sticemi a proteiny produkovan\u00fdmi injek\u010dn\u011b podanou mRNA, zat\u00edmco vlastn\u00ed data Moderny uk\u00e1zala, \u017ee se jej\u00ed LNP mohou hromadit v org\u00e1nech savc\u016f.<\/span><\/p>\n

Bez klinick\u00fdch d\u016fkaz\u016f z vy\u0161et\u0159ov\u00e1n\u00ed \u00famrt\u00ed jsou \u010dten\u00e1\u0159i znemo\u017en\u011bni posoudit, zda smrteln\u00e1 ud\u00e1lost skute\u010dn\u011b nesouvisela \u2013 nebo zda vakc\u00edna p\u0159isp\u011bla mechanismem, kter\u00fd studie nikdy nezkoumala.<\/span><\/p>\n

Od Jona Fleetwooda<\/span><\/em><\/strong><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

V\u011bdci z Moderny ji\u017e d\u0159\u00edve p\u0159ipustili, \u017ee l\u00e9ky s mRNA vykazuj\u00ed \u201enep\u0159ijatelnou \u00farove\u0148 toxicity\u201c, p\u0159i\u010dem\u017e…<\/p>\n","protected":false},"author":2,"featured_media":91285,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[8449,213,523,46],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/110530"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=110530"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/110530\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/91285"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=110530"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=110530"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=110530"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}