{"id":110361,"date":"2026-07-09T00:15:39","date_gmt":"2026-07-08T22:15:39","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=110361"},"modified":"2026-07-08T07:52:38","modified_gmt":"2026-07-08T05:52:38","slug":"kratce-pred-vypuknutim-eboly-v-africe-vyvinuly-usa-cina-velka-britanie-a-nemecko-mutanta-viru-ebola-rezistentniho-vuci-lekum","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/07\/09\/kratce-pred-vypuknutim-eboly-v-africe-vyvinuly-usa-cina-velka-britanie-a-nemecko-mutanta-viru-ebola-rezistentniho-vuci-lekum\/","title":{"rendered":"Kr\u00e1tce p\u0159ed vypuknut\u00edm eboly v Africe vyvinuly USA, \u010c\u00edna, Velk\u00e1 Brit\u00e1nie a N\u011bmecko mutanta viru Ebola rezistentn\u00edho v\u016f\u010di l\u00e9k\u016fm"},"content":{"rendered":"
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Experimenty s funk\u010dn\u00edm vylep\u0161en\u00edm, p\u0159i kter\u00fdch jsou patogeny mutov\u00e1ny, aby se staly rezistentn\u00edmi v\u016f\u010di l\u00e9k\u016fm, jsou ned\u00edlnou sou\u010d\u00e1st\u00ed v\u00fdvoje virologick\u00fdch l\u00e9\u010div.<\/span><\/strong><\/p>\n

Mezin\u00e1rodn\u00ed v\u00fdzkumn\u00e9 konsorcium, jeho\u017e sou\u010d\u00e1st\u00ed jsou p\u0159edn\u00ed instituce ze Spojen\u00fdch st\u00e1t\u016f, \u010c\u00edny, Velk\u00e9 Brit\u00e1nie a N\u011bmecka, tvrd\u00ed, \u017ee se mu poda\u0159ilo \u00fasp\u011b\u0161n\u011b vy\u0161lechtit mutantn\u00ed kmeny viru\u00a0<\/span>Orthoebola<\/span><\/em>\u00a0, kter\u00e9 jsou rezistentn\u00ed v\u016f\u010di neutraliza\u010dn\u00edmu \u00fa\u010dinku monoklon\u00e1ln\u00ed protil\u00e1tky mAb 11886.<\/span><\/p>\n

Svou pr\u00e1ci publikovali 7. kv\u011btna v \u010dasopise\u00a0<\/span>npj Viruses<\/span><\/a><\/em>\u00a0, jen n\u011bkolik dn\u00ed p\u0159edt\u00edm, ne\u017e ministerstvo zdravotnictv\u00ed Kon\u017esk\u00e9 demokratick\u00e9 republiky poprv\u00e9 ofici\u00e1ln\u011b ozn\u00e1milo<\/span><\/a>\u00a0vypuknut\u00ed eboly v roce 2026\u00a0.<\/span><\/p>\n

Tyto experimenty s ebolou, prov\u00e1d\u011bn\u00e9 za podm\u00ednek BSL-4 na Philippsov\u011b univerzit\u011b v Marburgu, zahrnovaly c\u00edlen\u00e9 vytv\u00e1\u0159en\u00ed a v\u00fdb\u011br \u00fadajn\u00fdch variant viru, kter\u00e9 obch\u00e1zej\u00ed terapeutickou neutralizaci.<\/span><\/p>\n

Experimenty spl\u0148uj\u00ed publikovan\u00e9 definice \u201eGain-of-Function\u201c (GOF).<\/span><\/p>\n

Podle\u00a0recenzn\u00edho \u010dl\u00e1nku<\/a>\u00a0publikovan\u00e9ho v\u00a0<\/span>\u010dasopise Advances in Applied Microbiology<\/span><\/em>\u00a0v roce 2022 :<\/span><\/p>\n

\u201eV\u00fdzkum vir\u016f zam\u011b\u0159en\u00fd na z\u00edsk\u00e1n\u00ed funkce si klade za c\u00edl zv\u00fd\u0161it p\u0159enosnost, replikaci vir\u016f, virulenci, rozsah hostitel\u016f, imunitn\u00ed \u00faniky nebo rezistenci v\u016f\u010di l\u00e9k\u016fm a vakc\u00edn\u00e1m s c\u00edlem z\u00edskat poznatky o virov\u00fdch mechanismech, vyvinout a analyzovat zv\u00ed\u0159ec\u00ed modely, urychlit v\u00fdvoj l\u00e9k\u016f a vakc\u00edn a zlep\u0161it p\u0159ipravenost na pandemie.\u201c<\/span><\/em><\/p>\n

Nov\u00e1 studie o ebole \u00fadajn\u011b vedla k vytvo\u0159en\u00ed mutovan\u00fdch, v\u016f\u010di l\u00e9k\u016fm rezistentn\u00edch patogen\u016f eboly ve jm\u00e9nu v\u00fdvoje l\u00e9k\u016f.<\/span><\/p>\n

To vyvol\u00e1v\u00e1 obavy o mezin\u00e1rodn\u00ed bezpe\u010dnost, jeliko\u017e Kongres, B\u00edl\u00fd d\u016fm, ministerstvo energetiky, FBI, CIA a n\u011bmeck\u00e1 Feder\u00e1ln\u00ed zpravodajsk\u00e1 slu\u017eba (BND) v\u0161echny potvrdily, \u017ee pandemie COVID-19 byla \u201epravd\u011bpodobn\u011b\u201c d\u016fsledkem laboratorn\u00ed nehody s geneticky modifikovan\u00fdmi patogeny.<\/span><\/p>\n

Chcete-li vyj\u00e1d\u0159it sv\u016fj nesouhlas s v\u00fdzkumem patogen\u016f zp\u016fsobuj\u00edc\u00edch pandemie financovan\u00fdm z dan\u00ed dan\u00ed,\u00a0m\u016f\u017eete kontaktovat\u00a0<\/span>NIAID zde<\/span><\/a>\u00a0,\u00a0<\/span>NIH zde<\/span><\/a>\u00a0a\u00a0<\/span>HHS zde.<\/span><\/a><\/p>\n

N\u011bkolik program\u016f americk\u00e9 vl\u00e1dy pro p\u0159ipravenost a reakci na ebolu bylo administrativn\u011b aktualizov\u00e1no ve feder\u00e1ln\u00ed datab\u00e1zi Assistance Listings v polovin\u011b ledna 2026 \u2013 p\u0159ibli\u017en\u011b t\u0159i a\u017e \u010dty\u0159i m\u011bs\u00edce p\u0159edt\u00edm, ne\u017e zdravotnick\u00e9 org\u00e1ny v Demokratick\u00e9 republice Kongo ozn\u00e1mily nejnov\u011bj\u0161\u00ed ohnisko eboly.<\/span><\/p>\n

Trumpova administrativa nyn\u00ed po\u017eaduje od Kongresu v\u00edce ne\u017e 1,4 miliardy dolar\u016f na pomoc v boji proti ebole, kr\u00e1tce pot\u00e9, co CDC uvolnilo 107 milion\u016f dolar\u016f z nouzov\u00fdch fond\u016f na boj s ebolou.<\/span><\/p>\n

Ameri\u010dt\u00ed da\u0148ov\u00ed poplatn\u00edci nyn\u00ed financuj\u00ed jak vytv\u00e1\u0159en\u00ed mutovan\u00fdch, l\u00e9ky odoln\u00fdch patogen\u016f eboly, tak i n\u00e1kladn\u00e1 vl\u00e1dn\u00ed opat\u0159en\u00ed v boji proti ebole.<\/span><\/p>\n

\"\"<\/figure>\n

V\u011bdci nut\u00ed virus, aby si vyvinul rezistenci.<\/span><\/strong><\/h3>\n

V\u011bdci uv\u00e1d\u011bj\u00ed, \u017ee k vytvo\u0159en\u00ed t\u011bchto mutant\u016f rezistentn\u00edch v\u016f\u010di l\u00e9k\u016fm pou\u017eili replikovatelnou verzi viru\u00a0zn\u00e1mou jako\u00a0<\/span>Ebola\u0394VP30 .<\/span><\/em><\/p>\n

T\u00fdm vysv\u011btluje, \u017ee v\u00fdvoj viru urychlil t\u00edm, \u017ee jej podrobil t\u0159em po sob\u011b jdouc\u00edm \u0161estidenn\u00edm cykl\u016fm cestuj\u00edc\u00edch.<\/span><\/p>\n

B\u011bhem t\u011bchto cykl\u016f byl virus \u00fadajn\u011b vystaven rostouc\u00edm koncentrac\u00edm protil\u00e1tky mAb 11886, po\u010d\u00ednaje 0,63 \u00b5g\/ml a zvy\u0161uj\u00edc\u00edm se na 5,0 \u00b5g\/ml, aby se podpo\u0159ila selekce mutac\u00ed, kter\u00e9 by mohly l\u00e9\u010dbu p\u0159e\u017e\u00edt.<\/span><\/p>\n

Po tomto procesu t\u00fdm izoloval jednotliv\u00e9 plaky, kter\u00e9 byly schopny p\u0159e\u017e\u00edt v p\u0159\u00edtomnosti 10 \u00b5g\/ml protil\u00e1tky.<\/span><\/p>\n

Nakonec v\u011bdci uvedli, \u017ee extrahovali virovou RNA a sekvenovali gen pro glykoprotein, aby identifikovali specifick\u00e9 genetick\u00e9 mutace zodpov\u011bdn\u00e9 za z\u00edskanou rezistenci.<\/span><\/p>\n

Experimenty identifikovaly dv\u011b specifick\u00e9 genetick\u00e9 mutace, kter\u00e9 jsou rezistentn\u00ed v\u016f\u010di l\u00e9k\u016fm.<\/span><\/strong><\/h3>\n

Sekven\u010dn\u00ed anal\u00fdza \u00fadajn\u011b identifikovala dv\u011b specifick\u00e9 genetick\u00e9 mutace, kter\u00e9 p\u0159\u00edmo negovaly \u00fa\u010dinnost protil\u00e1tky.<\/span><\/p>\n

Prvn\u00ed mutace, zn\u00e1m\u00e1 jako V505I, se nach\u00e1z\u00ed na N-konci GP2 a byla identifikov\u00e1na jako hlavn\u00ed p\u0159\u00ed\u010dina rezistence na monoklon\u00e1ln\u00ed protil\u00e1tku 11886.<\/span><\/p>\n

P\u0159edpokl\u00e1d\u00e1 se, \u017ee druh\u00e1 mutace, zn\u00e1m\u00e1 jako T402I, se nach\u00e1z\u00ed v mucinu podobn\u00e9 dom\u00e9n\u011b a p\u0159isp\u00edv\u00e1 k rezistenci nep\u0159\u00edm\u00fdmi \u00fa\u010dinky na to, jak virus zpracov\u00e1v\u00e1 sv\u00e9 \u00fadajn\u00e9 povrchov\u00e9 proteiny.<\/span><\/p>\n

Experiment\u00e1ln\u00ed data ze studie potvrdila, \u017ee ka\u017ed\u00e1 z t\u011bchto mutac\u00ed, pokud byla p\u0159\u00edtomna jednotliv\u011b, byla dostate\u010dn\u00e1 k tomu, aby se virus vyhnul neutralizaci p\u0159i koncentraci 10 \u00b5g\/ml.<\/span><\/p>\n

V\u00fdzkum podporovan\u00fd mezin\u00e1rodn\u00ed s\u00edt\u00ed finan\u010dn\u00edch subjekt\u016f a instituc\u00ed<\/span><\/strong><\/h3>\n

Vytvo\u0159en\u00ed t\u011bchto variant viru Ebola rezistentn\u00edch v\u016f\u010di l\u00e9k\u016fm bylo mo\u017en\u00e9 d\u00edky glob\u00e1ln\u00ed s\u00edti finan\u010dn\u00edch organizac\u00ed a partnerstv\u00ed mezi v\u011bdou a pr\u016fmyslem.<\/span><\/p>\n

Ve Spojen\u00e9m kr\u00e1lovstv\u00ed byl v\u00fdzkum podpo\u0159en Britskou radou pro l\u00e9ka\u0159sk\u00fd v\u00fdzkum prost\u0159ednictv\u00edm grantu iCASE PhD pro FRD (MR\/N01796X\/1) a Wellcome Trust prost\u0159ednictv\u00edm Senior Fellowship pro SJD (106917\/Z\/15\/Z).<\/span><\/p>\n

V N\u011bmecku byla pr\u00e1ce podpo\u0159ena N\u011bmeckou v\u00fdzkumnou nadac\u00ed prost\u0159ednictv\u00edm grantu pro TS (197785619\/SFB1021).<\/span><\/p>\n

V \u010c\u00edn\u011b bylo financov\u00e1n\u00ed poskytnuto prost\u0159ednictv\u00edm grant\u016f z Inova\u010dn\u00edho fondu pro l\u00e9ka\u0159sk\u00e9 v\u011bdy \u010c\u00ednsk\u00e9 akademie l\u00e9ka\u0159sk\u00fdch v\u011bd pro PR a AT (2024-12M-2-001-1 a 2018-12M-2-002).<\/span><\/p>\n

Ve Spojen\u00fdch st\u00e1tech byl v\u00fdzkum podpo\u0159en N\u00e1rodn\u00edmi instituty zdrav\u00ed (National Institutes of Health) prost\u0159ednictv\u00edm grantu U19 AI109762 pro EOS.<\/span><\/p>\n

Od Jona Fleetwooda<\/span><\/em><\/strong><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Experimenty s funk\u010dn\u00edm vylep\u0161en\u00edm, p\u0159i kter\u00fdch jsou patogeny mutov\u00e1ny, aby se staly rezistentn\u00edmi v\u016f\u010di l\u00e9k\u016fm,…<\/p>\n","protected":false},"author":2,"featured_media":110362,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1271,493,1561,492],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/110361"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=110361"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/110361\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/110362"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=110361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=110361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=110361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}