{"id":108445,"date":"2026-06-11T00:15:55","date_gmt":"2026-06-10T22:15:55","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=108445"},"modified":"2026-06-10T20:51:11","modified_gmt":"2026-06-10T18:51:11","slug":"cina-vyviji-mutovane-viry-chripky-h5n1-ktere-jsou-pro-savce-560-000krat-smrtelnejsi","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/06\/11\/cina-vyviji-mutovane-viry-chripky-h5n1-ktere-jsou-pro-savce-560-000krat-smrtelnejsi\/","title":{"rendered":"\u010c\u00edna vyv\u00edj\u00ed mutovan\u00e9 viry ch\u0159ipky H5N1, kter\u00e9 jsou pro savce 560 000kr\u00e1t smrteln\u011bj\u0161\u00ed"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong><span dir=\"auto\">Zat\u00edmco USA sou\u010dasn\u011b prov\u00e1d\u011bj\u00ed podobn\u00e9 laboratorn\u00ed experimenty ke zlep\u0161en\u00ed funk\u010dnosti.<\/span><\/strong><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Podle nov\u00e9 recenzovan\u00e9 studie publikovan\u00e9 v\u010dera v \u010dasopise\u00a0<\/span><em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/42246480\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">Emerging Microbes &amp; Infections<\/span><\/a><\/em><span dir=\"auto\">\u00a0tvrd\u00ed st\u00e1tem financovan\u00ed \u010d\u00edn\u0161t\u00ed v\u011bdci, \u017ee vyvinuli n\u011bkolik mutovan\u00fdch vir\u016f pta\u010d\u00ed ch\u0159ipky H5N1 a experiment\u00e1ln\u011b jimi infikovali savce, aby identifikovali genetick\u00e9 kombinace, kter\u00e9 drasticky zv\u00fd\u0161ily \u00famrtnost a zlep\u0161ily kompatibilitu viru s mechanismy lidsk\u00fdch bun\u011bk.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Odhalen\u00ed o \u010c\u00edn\u011b p\u0159ich\u00e1z\u00ed v dob\u011b, kdy ned\u00e1vn\u00e1 studie financovan\u00e1 americk\u00fdm ministerstvem zdravotnictv\u00ed a soci\u00e1ln\u00edch slu\u017eeb (HHS) uv\u00e1d\u00ed, \u017ee ameri\u010dt\u00ed v\u011bdci tak\u00e9 vyvinuli zbrusu nov\u00e9, laboratorn\u011b vytvo\u0159en\u00e9 viry pta\u010d\u00ed ch\u0159ipky \u201eFrankenstein\u201c se zlep\u0161enou schopnost\u00ed uniknout lidsk\u00e9mu imunitn\u00edmu syst\u00e9mu.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Tato odhalen\u00ed v rychl\u00e9m sledu p\u0159edstavuj\u00ed zrychluj\u00edc\u00ed se mezin\u00e1rodn\u00ed iniciativu vl\u00e1dou financovan\u00fdch v\u011bdc\u016f, jejich\u017e c\u00edlem je vyvinout a charakterizovat kmeny pta\u010d\u00ed ch\u0159ipky se zlep\u0161enou adaptac\u00ed na savce, lep\u0161\u00edm \u00fanikem z imunitn\u00edho syst\u00e9mu a zv\u00fd\u0161en\u00fdm pandemick\u00fdm potenci\u00e1lem.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Kongres, B\u00edl\u00fd d\u016fm, ministerstvo energetiky, FBI, CIA a n\u011bmeck\u00e1 Feder\u00e1ln\u00ed zpravodajsk\u00e1 slu\u017eba (BND) tvrd\u00ed, \u017ee smrt\u00edc\u00ed pandemie COVID-19 byla \u201epravd\u011bpodobn\u011b\u201c d\u016fsledkem laboratorn\u00ed nehody s geneticky modifikovan\u00fdmi patogeny.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Vznik pandemick\u00fdch patogen\u016f vyvol\u00e1v\u00e1 ot\u00e1zky t\u00fdkaj\u00edc\u00ed se mezin\u00e1rodn\u00ed bezpe\u010dnosti a informovan\u00e9ho souhlasu.<\/span><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/substackcdn.com\/image\/fetch\/$s_!8-i3!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep\/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2d8683d7-524b-4b77-beb4-e29281b71cf1_655x857.png\" alt=\"\" width=\"580\" height=\"759\" \/><\/figure>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Nov\u00e1 \u010d\u00ednsk\u00e1 studie byla provedena v Charbinsk\u00e9m veterin\u00e1rn\u00edm v\u00fdzkumn\u00e9m \u00fastavu (HVRI), kter\u00fd je sou\u010d\u00e1st\u00ed \u010c\u00ednsk\u00e9 akademie zem\u011bd\u011blsk\u00fdch v\u011bd (CAAS), ve vysoce zabezpe\u010den\u00fdch laborato\u0159\u00edch ABSL3 schv\u00e1len\u00fdch pro pr\u00e1ci s vysoce patogenn\u00edmi viry pta\u010d\u00ed ch\u0159ipky.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Pomoc\u00ed syst\u00e9mu reverzn\u00ed genetiky sest\u00e1vaj\u00edc\u00edho z osmi plazmid\u016f v\u011bdci vytvo\u0159ili reassortantn\u00ed a mutovan\u00e9 (\u201eFrankensteinovsk\u00e9\u201c) viry H5N1, kter\u00e9 nesly specifick\u00e9 polymer\u00e1zov\u00e9 mutace spojen\u00e9 s adaptac\u00ed na savce.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">\u00dadajn\u011b geneticky modifikovan\u00e9 viry byly pot\u00e9 intranaz\u00e1ln\u011b pod\u00e1ny my\u0161\u00edm BALB\/c za \u00fa\u010delem m\u011b\u0159en\u00ed \u0161\u00ed\u0159en\u00ed v tk\u00e1n\u00edch, \u00fa\u010dinnosti replikace a letality.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Podle \u010dl\u00e1nku se geneticky modifikovan\u00fd kmen rozmno\u017eil v cel\u00e9m t\u011ble a roz\u0161\u00ed\u0159il se do plic, nosn\u00edch sko\u0159\u00e1pek, mozku, sleziny a ledvin.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">V\u011bdci uvedli, \u017ee vysoce patogenn\u00ed kmen vykazoval nejm\u00e9n\u011b \u201e560 000n\u00e1sobn\u00fd\u201c rozd\u00edl v \u00famrtnosti ve srovn\u00e1n\u00ed s geneticky podobn\u00fdm virem H5N1.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Studie identifikovala t\u0159i mutace v proteinu PB2 polymer\u00e1zy \u2013 384L, 443R a 460M \u2013 kter\u00e9 spole\u010dn\u011b dramaticky zv\u00fd\u0161ily virulenci u savc\u016f.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Auto\u0159i tvrd\u00ed, \u017ee mutace umo\u017enily viru efektivn\u011bji vyu\u017e\u00edvat lidsk\u00e9 proteiny ANP32A\/B, kter\u00e9 jsou podle p\u0159evl\u00e1daj\u00edc\u00edho virologick\u00e9ho modelu pova\u017eov\u00e1ny za kl\u00ed\u010dov\u00e9 faktory hostitele pro replikaci ch\u0159ipky v lidsk\u00fdch bu\u0148k\u00e1ch.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Jednodu\u0161e \u0159e\u010deno, v\u011bdci tvrd\u00ed, \u017ee identifikovali kombinace mutac\u00ed, kter\u00e9 p\u0159isp\u011bly k tomu, \u017ee pta\u010d\u00ed ch\u0159ipka je v lidsk\u00fdch biologick\u00fdch syst\u00e9mech \u00fa\u010dinn\u011bj\u0161\u00ed.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Experimenty jsou v souladu s publikovan\u00fdmi definicemi zisku funkce, kter\u00e9 zahrnuj\u00ed zv\u00fd\u0161enou letalitu patogenu, adaptaci na savce a replikaci vir\u016f v lidsk\u00fdch bun\u011b\u010dn\u00fdch syst\u00e9mech.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Podle\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36243453\/\" target=\"_blank\" rel=\"noreferrer noopener\">recenzn\u00edho \u010dl\u00e1nku<\/a>\u00a0publikovan\u00e9ho v\u00a0<\/span><em><span dir=\"auto\">\u010dasopise Advances in Applied Microbiology<\/span><\/em><span dir=\"auto\">\u00a0v roce 2022 :<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">\u201eV\u00fdzkum vir\u016f zam\u011b\u0159en\u00fd na z\u00edsk\u00e1n\u00ed funkce si klade za c\u00edl zlep\u0161it p\u0159enosnost, replikaci vir\u016f, virulenci, rozsah hostitel\u016f, imunitn\u00ed \u00faniky nebo rezistenci v\u016f\u010di l\u00e9k\u016fm a vakc\u00edn\u00e1m s c\u00edlem z\u00edskat poznatky o virov\u00fdch mechanismech, vytvo\u0159it a analyzovat zv\u00ed\u0159ec\u00ed modely, urychlit v\u00fdvoj l\u00e9k\u016f a vakc\u00edn a zlep\u0161it p\u0159ipravenost na pandemie.\u201c<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">\u010c\u00ednsk\u00e1 studie spad\u00e1 do t\u00e9to kategorie, proto\u017ee v\u011bdci vyvinuli mutovan\u00e9 viry H5N1, kter\u00e9 se staly smrteln\u011bj\u0161\u00edmi pro savce a z\u00e1rove\u0148 zv\u00fd\u0161ily schopnost viru replikovat se a adaptovat se v lidsk\u00fdch bun\u011b\u010dn\u00fdch syst\u00e9mech.<\/span><\/p>\n<p class=\"wp-block-paragraph\"><span dir=\"auto\">Studie byla financov\u00e1na:<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">\u010c\u00ednsk\u00fd n\u00e1rodn\u00ed kl\u00ed\u010dov\u00fd program pro v\u00fdzkum a v\u00fdvoj,<\/span><\/li>\n<li><span dir=\"auto\">N\u00e1rodn\u00ed nadace pro p\u0159\u00edrodn\u00ed v\u011bdy \u010c\u00edny,<\/span><\/li>\n<li><span dir=\"auto\">Nadace pro p\u0159\u00edrodn\u00ed v\u011bdy provincie Chej-lung-\u0165iang<\/span><\/li>\n<li><span dir=\"auto\">a \u010c\u00ednsk\u00e1 akademie zem\u011bd\u011blsk\u00fdch v\u011bd.<\/span><\/li>\n<\/ul>\n<p class=\"wp-block-paragraph\"><strong><em><span dir=\"auto\">Od Jona Fleetwooda<\/span><\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/jonfleetwood.substack.com\/p\/china-engineers-mutant-h5n1-influenza\" target=\"_blank\" rel=\"nofollow noopener\"><span dir=\"auto\">Zdroj<\/span><\/a><\/span><\/h3>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Zat\u00edmco USA sou\u010dasn\u011b prov\u00e1d\u011bj\u00ed podobn\u00e9 laboratorn\u00ed experimenty ke zlep\u0161en\u00ed funk\u010dnosti. Podle nov\u00e9 recenzovan\u00e9 studie publikovan\u00e9&#8230;<\/p>\n","protected":false},"author":2,"featured_media":104247,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1042,30,579],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/108445"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=108445"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/108445\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/104247"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=108445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=108445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=108445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}