{"id":108396,"date":"2026-06-10T00:20:13","date_gmt":"2026-06-09T22:20:13","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=108396"},"modified":"2026-06-08T06:05:46","modified_gmt":"2026-06-08T04:05:46","slug":"dna-vakcina-proti-koronaviru-modelovana-umelou-inteligenci-prvni-testy-na-lidech","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/06\/10\/dna-vakcina-proti-koronaviru-modelovana-umelou-inteligenci-prvni-testy-na-lidech\/","title":{"rendered":"DNA vakc\u00edna proti koronaviru modelovan\u00e1 um\u011blou inteligenc\u00ed \u2013 prvn\u00ed testy na lidech"},"content":{"rendered":"
<\/div>\n

\u010clov\u011bk by si myslel, \u017ee koronavirov\u00e1 hysterie m\u011bla skon\u010dit u\u017e d\u00e1vno. Brit\u0161t\u00ed v\u011bdci v\u0161ak m\u00edsto toho pou\u017eili um\u011blou inteligenci k v\u00fdvoji vakc\u00edny, kter\u00e1 m\u00e1 b\u00fdt \u00fa\u010dinn\u00e1 proti v\u0161em typ\u016fm koronavir\u016f. Prvn\u00ed testy na lidech ji\u017e prob\u011bhly. Tato DNA vakc\u00edna v\u0161ak s sebou nese i v\u00e1\u017en\u00e1 rizika t\u00fdkaj\u00edc\u00ed se rozvoje imunitn\u00ed tolerance.<\/span><\/strong><\/p>\n

Um\u011bl\u00e1 inteligence se nyn\u00ed v n\u011bkter\u00fdch oblastech l\u00e9ka\u0159sk\u00e9ho v\u00fdzkumu vyu\u017e\u00edv\u00e1 k v\u00fdvoji nov\u00fdch l\u00e9k\u016f \u2013 nebo k l\u00e9\u010db\u011b jin\u00fdch nemoc\u00ed pomoc\u00ed dob\u0159e zn\u00e1m\u00fdch \u00fa\u010dinn\u00fdch l\u00e1tek. Tyto po\u010d\u00edta\u010dov\u00e9 programy jsou schopny objevit mnohem v\u00edce k\u0159\u00ed\u017eov\u00fdch odkaz\u016f a souvislost\u00ed ne\u017e lid\u00e9 pomoc\u00ed konven\u010dn\u00edch metod. V\u00fdzkumn\u00edci z Univerzity v Cambridge zvolili podobn\u00fd p\u0159\u00edstup ke koronavir\u016fm, pro kter\u00e9 se sna\u017e\u00ed vyvinout jakousi \u201euniverz\u00e1ln\u00ed vakc\u00ednu\u201c.<\/span><\/p>\n

A\u010dkoli covidov\u00e1 hysterie na\u0161t\u011bst\u00ed u\u017e d\u00e1vno skon\u010dila, brit\u0161t\u00ed v\u011bdci pova\u017euj\u00ed za mo\u017en\u00e9, \u017ee by se v budoucnu mezi lidstvem mohl znovu \u0161\u00ed\u0159it n\u011bjak\u00fd druh koronaviru, kter\u00fd by potenci\u00e1ln\u011b mohl zp\u016fsobit v\u00e1\u017en\u00e1 onemocn\u011bn\u00ed, jako je MERS, SARS nebo SARS-CoV-2. Vzhledem k prob\u00edhaj\u00edc\u00edmu v\u00fdzkumu nebezpe\u010dn\u00fdch patogen\u016f v mnoha zem\u00edch a tak\u00e9 vzhledem k vysok\u00e9 pravd\u011bpodobnosti, \u017ee by se mohly znovu objevit\u00a0<\/span>\u00faniky z laborato\u0159\u00ed, jako byl ten ve Wu-chanu<\/span><\/a>\u00a0(co\u017e by v\u011bdci samoz\u0159ejm\u011b nikdy ve\u0159ejn\u011b ne\u0159ekli), hledali takzvan\u00fd \u201esuperantigen\u201c.<\/span><\/p>\n

Slab\u00e1 imunita<\/span><\/h3>\n

Ve sv\u00e9 klinick\u00e9 studii, publikovan\u00e9 v \u010dasopise Journal of Infection pod n\u00e1zvem \u201e\u00a0<\/span>F\u00e1ze I, klinick\u00e1 studie pEVAC-PS, kandid\u00e1tsk\u00e9 vakc\u00edny proti pan-sarbecoviru, s eskalac\u00ed d\u00e1vky, bez jehly<\/span><\/a>\u00a0\u201c, vysv\u011btluj\u00ed, jak k n\u00e1vrhu kandid\u00e1tn\u00ed vakc\u00edny pEVAC-PS pou\u017eili um\u011blou inteligenci. Nechali program analyzovat tis\u00edce zn\u00e1m\u00fdch koronavir\u016f, aby na\u0161li spole\u010dn\u00fd pl\u00e1n \u2013 n\u011bco, co v\u0161echny tyto viry sd\u00edlej\u00ed. S takov\u00fdm \u201esuperantigenem\u201c by podle v\u011bdc\u016f mohl b\u00fdt lidsk\u00fd imunitn\u00ed syst\u00e9m p\u0159ipraven prakticky na v\u0161echny mo\u017en\u00e9 koronaviry \u2013 tak\u0159\u00edkaj\u00edc univerz\u00e1ln\u00ed vakc\u00edna.<\/span><\/p>\n

Tuto vakc\u00ednu vytvo\u0159enou um\u011blou inteligenc\u00ed testovali v klinick\u00e9 studii s 39 zdrav\u00fdmi dobrovoln\u00edky ve v\u011bku 18 a\u017e 50 let. Nebyly hl\u00e1\u0161eny \u017e\u00e1dn\u00e9 z\u00e1va\u017en\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky a druh\u00e1 d\u00e1vka vedla k men\u0161\u00edmu po\u010dtu ne\u017e\u00e1douc\u00edch reakc\u00ed ne\u017e prvn\u00ed. Protil\u00e1tkov\u00e1 odpov\u011b\u010f v\u0161ak byla pom\u011brn\u011b slab\u00e1, co\u017e je podle v\u011bdc\u016f pravd\u011bpodobn\u011b zp\u016fsobeno p\u0159edchoz\u00edmi infekcemi a o\u010dkov\u00e1n\u00edm proti COVID-19. Nicm\u00e9n\u011b se objevily prvn\u00ed n\u00e1znaky, \u017ee nov\u00e1 vakc\u00edna c\u00edl\u00ed na \u010d\u00e1sti viru odoln\u00e9 v\u016f\u010di mutac\u00edm. To nen\u00ed p\u0159ekvapiv\u00e9, vzhledem k \u00fakolu um\u011bl\u00e9 inteligence zam\u011b\u0159it se na spole\u010dn\u00e9 rysy v\u0161ech studovan\u00fdch koronavir\u016f.<\/span><\/p>\n

V\u011bdci nyn\u00ed prok\u00e1zali svou proveditelnost. Pl\u00e1nuje se studie f\u00e1ze 2 s v\u011bt\u0161\u00edm po\u010dtem \u00fa\u010dastn\u00edk\u016f. Bez \u00fa\u010dastn\u00edk\u016f, kte\u0159\u00ed se nenakazili Covidem-19 ani nebyli o\u010dkov\u00e1ni, v\u0161ak takov\u00e1 studie z\u016fst\u00e1v\u00e1 ot\u00e1zkou \u2013 kv\u016fli probl\u00e9mu tzv. antigenn\u00edho h\u0159\u00edchu. Tato tzv. DNA vakc\u00edna zalo\u017een\u00e1 na plazmidu, kter\u00e1 se spol\u00e9h\u00e1 na DNA a nikoli (jako u spole\u010dnost\u00ed Pfizer\/BioNTech nebo Moderna) na RNA, p\u0159en\u00e1\u0161\u00ed genetickou informaci o antigenu ve form\u011b stabiln\u00edch DNA plazmid\u016f a na rozd\u00edl od vektorov\u00fdch vakc\u00edn (jako jsou ty od spole\u010dnost\u00ed AstraZeneca nebo Sputnik) nevy\u017eaduje oslaben\u00fd virus-nosi\u010d.<\/span><\/p>\n

Skryt\u00e1 rizika<\/span><\/h3>\n

I kdy\u017e jsou takov\u00e9 DNA vakc\u00edny pova\u017eov\u00e1ny za relativn\u011b bezpe\u010dn\u00e9, existuje p\u0159inejmen\u0161\u00edm teoretick\u00e9 riziko integrace genomu (mutageneze), kter\u00e1 by mohla v\u00e9st k mutac\u00edm nebo dokonce rakovin\u011b. Rozvoj autoimunitn\u00edch onemocn\u011bn\u00ed s anti-DNA antigeny je tak\u00e9 pova\u017eov\u00e1n za mo\u017en\u00fd, a\u010dkoli takov\u00e9 reakce dosud nebyly v klinick\u00fdch studi\u00edch pozorov\u00e1ny. I kdy\u017e jsou takov\u00e9 vakc\u00edny (na rozd\u00edl od nebezpe\u010dn\u00fdch genov\u00fdch terapi\u00ed s mRNA) skute\u010dn\u011b zaj\u00edmav\u00e9, existuj\u00ed ur\u010dit\u00e1 rizika. Krom\u011b ji\u017e zm\u00edn\u011bn\u00fdch potenci\u00e1ln\u00edch probl\u00e9m\u016f existuje tak\u00e9 riziko, \u017ee v d\u016fsledku stability DNA by si lidsk\u00fd imunitn\u00ed syst\u00e9m mohl vyvinout imunitn\u00ed toleranci, zvyknout si na antigen a nakonec by v re\u00e1ln\u00e9 infekci selhal v boji proti skute\u010dn\u00e9mu viru.<\/span><\/p>\n

To tak\u00e9 znamen\u00e1, \u017ee pokud by tato \u201euniverz\u00e1ln\u00ed vakc\u00edna proti koronaviru\u201c byla n\u011bkdy obecn\u011b schv\u00e1lena a \u0161iroce pou\u017e\u00edv\u00e1na, mohla by m\u00edt v p\u0159\u00edpad\u011b budouc\u00edho koronavirov\u00e9ho ohniska v\u00e1\u017en\u00e9 n\u00e1sledky. S takovou imunitn\u00ed toleranc\u00ed by se viry mohly zcela neru\u0161en\u011b mno\u017eit a \u0161\u00ed\u0159it, ani\u017e by na n\u011b imunitn\u00ed syst\u00e9m reagoval. Dokonce i b\u011b\u017en\u00e9 nachlazen\u00ed (n\u011bkdy tak\u00e9 zp\u016fsoben\u00e9 koronaviry) by se pak stalo chronick\u00fdm onemocn\u011bn\u00edm, proto\u017ee imunitn\u00ed syst\u00e9m tyto viry jednodu\u0161e ignoruje. Co by se mohlo st\u00e1t, kdyby se roz\u0161\u00ed\u0159ila nov\u00e1 varianta SARS \u2013 si lze jen p\u0159edstavit.<\/span><\/p>\n

Zat\u00edmco star\u0161\u00ed generace (ty, kter\u00e9 ji\u017e byly vystaveny viru SARS-CoV-2 a vakc\u00edn\u00e1m nebo injekc\u00edm genu mRNA) mohou m\u00edt st\u00e1le ur\u010ditou z\u00e1kladn\u00ed ochranu, vyvst\u00e1v\u00e1 ot\u00e1zka, co se stane s kojenci a batolaty, pokud se r\u016fzn\u00e9 vl\u00e1dy rozhodnou toto o\u010dkov\u00e1n\u00ed zahrnout do sv\u00fdch imuniza\u010dn\u00edch program\u016f. Mohly by tak v\u00e9st celou generaci do smrt\u00edc\u00ed pasti.<\/span><\/p>\n

\"\"<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u010clov\u011bk by si myslel, \u017ee koronavirov\u00e1 hysterie m\u011bla skon\u010dit u\u017e d\u00e1vno. Brit\u0161t\u00ed v\u011bdci v\u0161ak m\u00edsto…<\/p>\n","protected":false},"author":2,"featured_media":108397,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[23,895,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/108396"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=108396"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/108396\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/108397"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=108396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=108396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=108396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}