{"id":108154,"date":"2026-06-05T00:18:14","date_gmt":"2026-06-04T22:18:14","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=108154"},"modified":"2026-06-04T07:38:36","modified_gmt":"2026-06-04T05:38:36","slug":"studie-vitamin-d-muze-u-nekterych-lidi-snizovat-riziko-cukrovky","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/06\/05\/studie-vitamin-d-muze-u-nekterych-lidi-snizovat-riziko-cukrovky\/","title":{"rendered":"Studie: Vitam\u00edn D m\u016f\u017ee u n\u011bkter\u00fdch lid\u00ed sni\u017eovat riziko cukrovky"},"content":{"rendered":"
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Nezdrav\u00fd modern\u00ed \u017eivotn\u00ed styl zp\u016fsobuje, \u017ee se u st\u00e1le v\u011bt\u0161\u00edho po\u010dtu lid\u00ed rozv\u00edj\u00ed cukrovka. I kdy\u017e je obt\u00ed\u017en\u00e9 tomu p\u0159edch\u00e1zet bez zm\u011bn ve stravov\u00e1n\u00ed a v\u011bt\u0161\u00edho cvi\u010den\u00ed, vysok\u00e9 d\u00e1vky vitaminu D by mohly alespo\u0148 zpomalit progresi onemocn\u011bn\u00ed u n\u011bkter\u00fdch specifick\u00fdch pacient\u016f s prediabetem. Nazna\u010duj\u00ed to nov\u00e1 studie.<\/span><\/strong><\/p>\n

Diabetes je nyn\u00ed pova\u017eov\u00e1n za roz\u0161\u00ed\u0159en\u00e9 onemocn\u011bn\u00ed. V N\u011bmecku sou\u010dasn\u00e9 odhady ukazuj\u00ed, \u017ee m\u00e1 diabetes p\u0159ibli\u017en\u011b 11 milion\u016f lid\u00ed \u2013 plus dal\u0161\u00edch 20 milion\u016f lid\u00ed (asi p\u011btina v\u0161ech dosp\u011bl\u00fdch) s prediabetem. Situace je podobn\u00e1 v Rakousku, zat\u00edmco \u0160v\u00fdca\u0159i (pravd\u011bpodobn\u011b d\u00edky zdrav\u011bj\u0161\u00edmu \u017eivotn\u00edmu stylu a v\u00fdrazn\u011b ni\u017e\u0161\u00ed m\u00ed\u0159e obezity) jsou diabetem posti\u017eeni podstatn\u011b m\u00e9n\u011b. Tato \u010d\u00edsla nejsou tak alarmuj\u00edc\u00ed jako ve Spojen\u00fdch st\u00e1tech, kde m\u00e1 nyn\u00ed prediabetes p\u0159ibli\u017en\u011b 115 milion\u016f Ameri\u010dan\u016f (asi dv\u011b p\u011btiny) a ka\u017ed\u00fd osm\u00fd Ameri\u010dan (asi 40 milion\u016f lid\u00ed) ji\u017e m\u00e1 diabetes.<\/span><\/p>\n

Nicm\u00e9n\u011b alespo\u0148 u v\u00fdznamn\u00e9 \u010d\u00e1sti t\u011bch, u kter\u00fdch byla ofici\u00e1ln\u011b diagnostikov\u00e1na prediabetes, existuje jisk\u0159i\u010dka nad\u011bje, \u017ee n\u00e1stup diabetu 2. typu lze odd\u00e1lit. Genetick\u00fd rys p\u0159\u00edtomn\u00fd u p\u0159ibli\u017en\u011b 70 procent dosp\u011bl\u00fdch s prediabetem by mohl p\u0159isp\u011bt k v\u00fdznamn\u00e9mu sn\u00ed\u017een\u00ed rizika vzniku onemocn\u011bn\u00ed p\u0159i u\u017e\u00edv\u00e1n\u00ed vysok\u00fdch d\u00e1vek vitaminu D. Toto je z\u00e1v\u011br studie publikovan\u00e9 v JAMA Network Open s n\u00e1zvem \u201e\u00a0<\/span>Polymorfismy receptoru vitaminu D a vliv suplementace vitaminem D na riziko diabetu u dosp\u011bl\u00fdch s prediabetem<\/span><\/a>\u00a0\u201c.<\/span><\/p>\n

V\u00fdzkum v\u011bdc\u016f navazuje na tzv.\u00a0<\/span>studii D2d<\/span><\/a> . V\u00edce ne\u017e 2 000 dosp\u011bl\u00fdch Ameri\u010dan\u016f s prediabetem bylo n\u00e1hodn\u011b rozd\u011bleno do skupiny u\u017e\u00edvaj\u00edc\u00ed 4 000 jednotek vitaminu D nebo do skupiny u\u017e\u00edvaj\u00edc\u00ed placebo \u2013 po dobu a\u017e 3,5 roku. Studie zpo\u010d\u00e1tku neprok\u00e1zala \u017e\u00e1dn\u00e9 v\u00fdznamn\u00e9 rozd\u00edly mezi skupinami. Doporu\u010den\u00fd denn\u00ed p\u0159\u00edjem pro dosp\u011bl\u00e9 je 600 a\u017e 800 jednotek.<\/span><\/p>\n

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Kdy\u017e v\u0161ak v\u011bdci analyzovali DNA \u00fa\u010dastn\u00edk\u016f, objevil se komplexn\u011bj\u0161\u00ed obraz: Jedinci s ur\u010dit\u00fdmi variantami \u2013 zn\u00e1m\u00fdmi jako AC nebo CC \u2013 v genu zvan\u00e9m ApaI vykazovali v\u00fdznamn\u011b pozitivn\u00ed reakci na suplementaci. B\u011bhem 3,5 let m\u011bli nositel\u00e9 t\u011bchto variant o 19 procent ni\u017e\u0161\u00ed riziko vzniku cukrovky. Naproti tomu p\u0159ibli\u017en\u011b 30 procent s variantou AA nevykazovalo \u017e\u00e1dn\u00e9 pozitivn\u00ed v\u00fdsledky z dodate\u010dn\u00e9ho u\u017e\u00edv\u00e1n\u00ed vitaminu D.<\/span><\/p>\n

Vitam\u00edn D v krvi se v t\u011ble p\u0159em\u011b\u0148uje na svou aktivn\u00ed formu. Receptory vitam\u00ednu D se nach\u00e1zej\u00ed ve vysok\u00e9 hustot\u011b v mnoha bu\u0148k\u00e1ch v cel\u00e9m t\u011ble. Kdy\u017e se vitam\u00edn D v\u00e1\u017ee na tyto receptory, podporuje bu\u0148ky v jejich p\u0159\u00edslu\u0161n\u00fdch funkc\u00edch. V bu\u0148k\u00e1ch slinivky b\u0159i\u0161n\u00ed vitam\u00edn D podporuje uvol\u0148ov\u00e1n\u00ed inzul\u00ednu k regulaci hladiny cukru v krvi. Lid\u00e9 s variantami AC a CC byli citliv\u011bj\u0161\u00ed na vitam\u00edn D, a proto m\u011bli z dopl\u0148k\u016f stravy v\u011bt\u0161\u00ed prosp\u011bch ne\u017e ti s variantou AA.<\/span><\/p>\n

To znamen\u00e1, \u017ee po zji\u0161t\u011bn\u00ed, zda m\u00e1 pacient s prediabetem odpov\u00eddaj\u00edc\u00ed genov\u00e9 varianty (AC nebo CC), mohou l\u00e9ka\u0159i p\u0159edepsat dopl\u0148ky vitam\u00ednu D jako preventivn\u00ed opat\u0159en\u00ed (pod l\u00e9ka\u0159sk\u00fdm dohledem kv\u016fli mo\u017en\u00fdm vedlej\u0161\u00edm \u00fa\u010dink\u016fm). To je zvl\u00e1\u0161t\u011b d\u016fle\u017eit\u00e9 b\u011bhem tmav\u0161\u00edch m\u011bs\u00edc\u016f roku a v p\u0159\u00edpadech st\u00e1vaj\u00edc\u00edho nedostatku vitam\u00ednu D. Za zm\u00ednku tak\u00e9 stoj\u00ed, \u017ee ofici\u00e1ln\u00ed doporu\u010den\u00e9 hladiny p\u0159\u00edjmu jsou\u00a0<\/span>pravd\u011bpodobn\u011b p\u0159\u00edli\u0161 n\u00edzk\u00e9<\/span><\/a>\u00a0. Mimochodem, vitam\u00edn D ji\u017e prok\u00e1zal ur\u010dit\u00e9 pozitivn\u00ed \u00fa\u010dinky v p\u0159edchoz\u00edch studi\u00edch mlad\u00fdch pacient\u016f s diabetem 1. typu (vrozen\u00e1 forma).\u00a0<\/span>O tom se v\u011bnoval Report24<\/span><\/a>\u00a0. Zd\u00e1 se tedy, \u017ee \u201eslune\u010dn\u00ed vitam\u00edn\u201c m\u00e1 na na\u0161e zdrav\u00ed v\u00fdrazn\u011b v\u00edce pozitivn\u00edch \u00fa\u010dink\u016f, ne\u017e si mnoho lid\u00ed uv\u011bdomuje.<\/span><\/p>\n

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Nezdrav\u00fd modern\u00ed \u017eivotn\u00ed styl zp\u016fsobuje, \u017ee se u st\u00e1le v\u011bt\u0161\u00edho po\u010dtu lid\u00ed rozv\u00edj\u00ed cukrovka. I…<\/p>\n","protected":false},"author":2,"featured_media":108155,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[5355,839,3973],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/108154"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=108154"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/108154\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/108155"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=108154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=108154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=108154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}