{"id":107898,"date":"2026-06-01T06:04:48","date_gmt":"2026-06-01T04:04:48","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=107898"},"modified":"2026-06-01T06:04:48","modified_gmt":"2026-06-01T04:04:48","slug":"lzi-o-ucinnosti-vakciny-gardasil-se-stale-mnozi","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/06\/01\/lzi-o-ucinnosti-vakciny-gardasil-se-stale-mnozi\/","title":{"rendered":"L\u017ei o \u00fa\u010dinnosti vakc\u00edny Gardasil se st\u00e1le mno\u017e\u00ed"},"content":{"rendered":"
<\/div>\n

Koment\u00e1\u0159e k \u010dl\u00e1nku, kter\u00fd tvrd\u00ed, \u017ee o\u010dkov\u00e1n\u00ed vakc\u00ednou Gardasil sni\u017euje riziko rakoviny d\u011blo\u017en\u00edho \u010d\u00edpku<\/span><\/strong><\/h3>\n

Ned\u00e1vn\u00e1 \u0161v\u00e9dsk\u00e1 studie<\/span><\/span>1<\/span><\/sup><\/a><\/span>\u00a0,<\/span><\/span>Studie<\/span><\/sup><\/a><\/span>\u00a0publikovan\u00e1 ve dvou d\u0159\u00edve presti\u017en\u00edch \u010dasopisech a \u0161iroce citovan\u00e1 v m\u00e9di\u00edch, kterou zneu\u017e\u00edv\u00e1 Gavi a dal\u0161\u00ed zast\u00e1nci vakc\u00edny Gardasil, tvrd\u00ed, \u017ee o\u010dkov\u00e1n\u00ed sni\u017euje riziko rakoviny d\u011blo\u017en\u00edho \u010d\u00edpku. Jedn\u00e1 se v\u0161ak o zaujat\u00fd \u010dl\u00e1nek, kter\u00fd porovn\u00e1v\u00e1 skupiny s velmi odli\u0161n\u00fdmi progn\u00f3zami a ve sv\u00e9 anal\u00fdze tyto rozd\u00edly nezohled\u0148uje.<\/span><\/p>\n

Hlavn\u00ed vysv\u011btlen\u00ed pozorovan\u00fdch rozd\u00edl\u016f ve v\u00fdskytu rakoviny spo\u010d\u00edv\u00e1 ve v\u011bku srovn\u00e1van\u00fdch skupin. V t\u00e9to studii se 65 % neo\u010dkovan\u00fdch \u017een narodilo p\u0159ed rokem 1989, oproti pouze 4 % o\u010dkovan\u00fdch \u017een.<\/span><\/p>\n

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50 % neo\u010dkovan\u00fdch osob (583881\/1145112) bylo tedy star\u0161\u00edch 30 let, ve srovn\u00e1n\u00ed s pouze 1 % o\u010dkovan\u00fdch osob. Vzhledem k tomu, \u017ee riziko rakoviny p\u0159\u00edmo souvis\u00ed s pokro\u010dil\u00fdm v\u011bkem (nad 30 let), toto zkreslen\u00e9 zahrnut\u00ed zcela zkresluje srovn\u00e1n\u00ed ve prosp\u011bch o\u010dkov\u00e1n\u00ed.<\/span><\/p>\n

V\u0161\u00edm\u00e1me si tak\u00e9 ni\u017e\u0161\u00ed kulturn\u00ed a ekonomick\u00e9 \u00farovn\u011b neo\u010dkovan\u00fdch \u017een, jak je pops\u00e1no v tabulce 1:<\/span><\/p>\n

Kulturn\u00ed a ekonomick\u00e1 \u00farove\u0148 hraje prokazatelnou roli v \u017eivotn\u00edm stylu, p\u0159\u00edstupu ke zdravotn\u00ed p\u00e9\u010di a celkov\u00e9 d\u00e9lce \u017eivota; pozorovan\u00fd rozd\u00edl mezi t\u011bmito dv\u011bma skupinami proto m\u016f\u017ee vysv\u011btlovat i n\u011bkter\u00e9 rozd\u00edly v jejich v\u00fdvoji. Tyto dv\u011b skupiny proto nelze skute\u010dn\u011b srovn\u00e1vat!<\/span><\/p>\n

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\"\"<\/a><\/figure>\n<\/div>\n
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\"\"<\/a><\/figure>\n<\/div>\n

Obrovsk\u00e1 odchylka p\u0159i formov\u00e1n\u00ed skupin je patrn\u00e1 z rozd\u00edlu v celkov\u00e9 \u00famrtnosti mezi nimi. Tento \u010dl\u00e1nek uv\u00e1d\u00ed\u00a0<\/span>\u010dty\u0159ikr\u00e1t vy\u0161\u0161\u00ed celkovou \u00famrtnost u neo\u010dkovan\u00fdch jedinc\u016f (2\/1000) ne\u017e u o\u010dkovan\u00fdch jedinc\u016f (0,5\/1000).<\/span><\/strong><\/p>\n

Tento v\u00fdznamn\u00fd rozd\u00edl mezi ob\u011bma skupinami mohl autor\u016fm umo\u017enit tvrdit, \u017ee o\u010dkov\u00e1n\u00ed chr\u00e1n\u00ed i p\u0159ed smrt\u00ed z jak\u00e9koli p\u0159\u00ed\u010diny (co\u017e si sami neodv\u00e1\u017eili \u0159\u00edct).<\/span><\/p>\n

Hlavn\u00ed auto\u0159i \u010dl\u00e1nku pracuj\u00ed v Karolinska Institute ve Stockholmu, jeho\u017e po sob\u011b jdouc\u00ed publikace na toto t\u00e9ma si soustavn\u011b odporuj\u00ed. V dubnu 2018 publikoval\u00a0<\/span>\u010dasopis The Indian Journal of Medical Ethics<\/span><\/em>\u00a0(IJME) \u010dl\u00e1nek s n\u00e1zvem\u00a0<\/span>\u201eZv\u00fd\u0161en\u00fd v\u00fdskyt rakoviny d\u011blo\u017en\u00edho \u010d\u00edpku ve \u0160v\u00e9dsku: mo\u017en\u00e1 souvislost s o\u010dkov\u00e1n\u00edm proti HPV\u201c,<\/span><\/em>\u00a0kter\u00fd byl n\u00e1sledn\u011b sta\u017een, proto\u017ee autor pou\u017e\u00edval pseudonym. V roce 2020 Karolinska Institute uznal zv\u00fd\u0161en\u00fd v\u00fdskyt od o\u010dkov\u00e1n\u00ed, ale p\u0159ipsal jej nedostatk\u016fm ve screeningu.<\/span><\/span>3.<\/span><\/sup><\/a><\/span>\u00a0Dnes sponzoruje zaujat\u00e9 \u010dl\u00e1nky ve prosp\u011bch o\u010dkov\u00e1n\u00ed. Jak jim m\u016f\u017eeme slep\u011b v\u011b\u0159it?<\/span><\/p>\n

Pokud auto\u0159i (z nich\u017e dva obdr\u017eeli pen\u00edze od spole\u010dnosti Merck) skute\u010dn\u011b cht\u011bli vyhodnotit \u00fa\u010dinnost o\u010dkov\u00e1n\u00ed, m\u011bli prov\u00e9st randomizovanou kontrolovanou studii (nejvy\u0161\u0161\u00ed \u00farove\u0148 d\u016fkaz\u016f) nebo studii se srovnateln\u00fdmi skupinami, co\u017e zjevn\u011b nen\u00ed pravda. Jejich \u010dl\u00e1nek nen\u00ed nic jin\u00e9ho ne\u017e dal\u0161\u00ed reklamn\u00ed kousek.<\/span><\/p>\n

Je skli\u010duj\u00edc\u00ed sledovat korupci v l\u00e9ka\u0159sk\u00e9m v\u00fdzkumu a kdysi presti\u017en\u00edch \u010dasopis\u016f, kter\u00e9 nyn\u00ed souhlas\u00ed s publikov\u00e1n\u00edm takov\u00fdch zaujat\u00fdch \u010dl\u00e1nk\u016f. Je v\u0161ak pravda, \u017ee vzhledem k tomu, \u017ee plat\u00edc\u00edch p\u0159edplatitel\u016f je m\u00e1lo, z\u00e1vis\u00ed p\u0159\u00edjmy t\u011bchto \u010dasopis\u016f p\u0159edev\u0161\u00edm na farmaceutick\u00fdch spole\u010dnostech, kter\u00e9 ovliv\u0148uj\u00ed v\u00fdb\u011br \u010dl\u00e1nk\u016f k publikaci.<\/span><\/span>4<\/span><\/sup><\/a><\/span>\u00a0,<\/span><\/span>5<\/span><\/sup><\/a><\/span>\u00a0,<\/span><\/span>6<\/span><\/sup><\/a><\/span>\u00a0,<\/span><\/span>7<\/span><\/sup><\/a><\/span><\/p>\n

Smutn\u00e9 \u010dasy, kdy etika m\u00e1 tak malou v\u00e1hu ve srovn\u00e1n\u00ed se st\u0159etem z\u00e1jm\u016f.<\/span><\/p>\n

Zdroj:\u00a0<\/span>Dr. Nicole Del\u00e9pine<\/span><\/a><\/em><\/strong><\/p>\n

    \n
  1. <\/span>Jaya Lei, Ph.D.\u00a0<\/span>https:\/\/orcid.org\/0000-0002-4718-1414<\/span><\/a>\u00a0, Alexandre Ploner, Ph.D.\u00a0<\/span>\u201eO\u010dkov\u00e1n\u00ed proti HPV a riziko invazivn\u00edho karcinomu d\u011blo\u017en\u00edho \u010d\u00edpku\u201c<\/span><\/em>\u00a0NEJ Med 2020; 383: 1340-1348<\/span>
    \nDOI: 10.1056\/NEJMoa1917338<\/span><\/li>\n
  2. <\/span>Shiqiang Wu. Dlouhodob\u00e9 sledov\u00e1n\u00ed rizika invazivn\u00edho karcinomu d\u011blo\u017en\u00edho \u010d\u00edpku po kvadrivalentn\u00ed vakcinaci proti HPV: studie zalo\u017een\u00e1 na n\u00e1rodn\u00edm registru.<\/span>
    \nBMJ 2026; 392. doi:\u00a0<\/span>    https:\/\/doi.org\/10.1136\/bmj-2025-087326<\/span><\/a><\/li>\n
  3. <\/span>Jiangrong Wang, Bengt Andrae, Bj\u00f6rn Strander, P\u00e4r Spar\u00e9n, Joakim Dillner\u00a0<\/span>\u201eN\u00e1r\u016fst incidence rakoviny d\u011blo\u017en\u00edho \u010d\u00edpku ve \u0160v\u00e9dsku v souvislosti s histori\u00ed screeningu: popula\u010dn\u00ed kohortov\u00e1 studie\u201c<\/span><\/em>\u00a0, Acta Oncologica, 59:8, 988-993, DOI:10.1080\/0284186X.2020.1764095\u00a0<\/span>https:\/\/doi.org\/10.1080\/0284186X.2020.1764095<\/span><\/a><\/li>\n
  4. <\/span>Bekelman JE, Li Y, Gross CP,\u00a0<\/span>\u201eRozsah a dopad finan\u010dn\u00edch st\u0159et\u016f z\u00e1jm\u016f v biomedic\u00ednsk\u00e9m v\u00fdzkumu: systematick\u00fd p\u0159ehled\u201c<\/span><\/em>\u00a0, J Am Med Assoc, sv. 289, \u010d. 4, 2003, s. 454\u201365 (PMID 12533125, DOI 10.1001\/jama.289.4.454)<\/span><\/li>\n
  5. <\/span>Ridker PM, Torres J,\u00a0<\/span>\u201eHl\u00e1\u0161en\u00e9 v\u00fdsledky v hlavn\u00edch kardiovaskul\u00e1rn\u00edch klinick\u00fdch studi\u00edch financovan\u00fdch ziskov\u00fdmi a neziskov\u00fdmi organizacemi: 2000\u20132005\u201c<\/span><\/em>\u00a0, JAMA, ro\u010d. 295, \u010d. 19, 2006, s. 2270\u20132274 (PMID 16705108, DOI 10.1001\/jama.295.19.2270)<\/span><\/li>\n
  6. <\/span>Andreas Lundh, Joel Lexchin, Barbara Mintzes a Jeppe B. Schroll,\u00a0<\/span>\u201eSponzorstv\u00ed ze strany pr\u016fmyslu a v\u00fdsledky v\u00fdzkumu\u201c<\/span><\/em>\u00a0, Cochrane Database of Systematic Reviews, 16. \u00fanora 2017<\/span><\/li>\n
  7. <\/span>Bhandari M, Busse JW, Jackowski D, Montori VM, Sch\u00fcnemann H, Sprague S, Mears D, Schemitsch EH, Heels-Ansdell D, Devereaux PJ,\u00a0<\/span>\u201eSouvislost mezi financov\u00e1n\u00edm z pr\u016fmyslu a statisticky v\u00fdznamn\u00fdmi propr\u016fmyslov\u00fdmi zji\u0161t\u011bn\u00edmi v l\u00e9ka\u0159sk\u00fdch a chirurgick\u00fdch randomizovan\u00fdch studi\u00edch\u201c<\/span><\/em>\u00a0, Can Med Assoc J, ro\u010d. 170, \u010d. 4, 2004, s. 477\u2013478.<\/span><\/li>\n<\/ol>\n

     <\/p>\n","protected":false},"excerpt":{"rendered":"

    Koment\u00e1\u0159e k \u010dl\u00e1nku, kter\u00fd tvrd\u00ed, \u017ee o\u010dkov\u00e1n\u00ed vakc\u00ednou Gardasil sni\u017euje riziko rakoviny d\u011blo\u017en\u00edho \u010d\u00edpku Ned\u00e1vn\u00e1…<\/p>\n","protected":false},"author":2,"featured_media":107899,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[11072,851,1366,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/107898"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=107898"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/107898\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/107899"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=107898"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=107898"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=107898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}