{"id":106308,"date":"2026-05-12T00:12:20","date_gmt":"2026-05-11T22:12:20","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=106308"},"modified":"2026-05-11T09:37:02","modified_gmt":"2026-05-11T07:37:02","slug":"spolecnost-moderna-potvrzuje-ze-jeji-nova-vakcina-proti-chripce-mrna-1010-zpusobuje-sestkrat-zavaznejsi-vedlejsi-ucinky","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/05\/12\/spolecnost-moderna-potvrzuje-ze-jeji-nova-vakcina-proti-chripce-mrna-1010-zpusobuje-sestkrat-zavaznejsi-vedlejsi-ucinky\/","title":{"rendered":"Spole\u010dnost Moderna potvrzuje, \u017ee jej\u00ed nov\u00e1 vakc\u00edna proti ch\u0159ipce mRNA-1010 zp\u016fsobuje \u0161estkr\u00e1t z\u00e1va\u017en\u011bj\u0161\u00ed vedlej\u0161\u00ed \u00fa\u010dinky"},"content":{"rendered":"<div id=\"fb-root\"><\/div>\n<div class=\"elementor-element elementor-element-1fb4c2c elementor-widget elementor-widget-theme-post-content\" data-id=\"1fb4c2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n<div class=\"elementor-widget-container\">\n<p class=\"has-medium-font-size\"><strong><span dir=\"auto\">Neexistuj\u00ed \u017e\u00e1dn\u00e9 d\u016fkazy o tom, \u017ee by o\u010dkov\u00e1n\u00ed vedlo ke sn\u00ed\u017een\u00ed \u00famrt\u00ed nebo po\u010dtu z\u00e1va\u017en\u00fdch hospitalizac\u00ed.<\/span><\/strong><\/p>\n<p><span dir=\"auto\">Ned\u00e1vn\u00e1 studie f\u00e1ze 3 publikovan\u00e1 v\u00a0<\/span><a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2516491\" target=\"_blank\" rel=\"noreferrer noopener\"><em><span dir=\"auto\">\u010dasopise New England Journal of Medicine<\/span><\/em><\/a><span dir=\"auto\">\u00a0potvrdila, \u017ee experiment\u00e1ln\u00ed mRNA vakc\u00edna proti sez\u00f3nn\u00ed ch\u0159ipce od spole\u010dnosti Moderna, mRNA-1010, zp\u016fsobila p\u0159ibli\u017en\u011b \u0161estkr\u00e1t v\u00edce z\u00e1va\u017en\u00fdch kr\u00e1tkodob\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f ne\u017e standardn\u00ed d\u00e1vky vakc\u00edn proti ch\u0159ipce a z\u00e1rove\u0148 vedla k absolutn\u00edmu sn\u00ed\u017een\u00ed symptomatick\u00fdch, PCR potvrzen\u00fdch onemocn\u011bn\u00ed podobn\u00fdch ch\u0159ipce o m\u00e9n\u011b ne\u017e jeden procentn\u00ed bod.<\/span><\/p>\n<p><span dir=\"auto\">Studie zjistila, \u017ee p\u0159\u00edjemci vakc\u00edny proti ch\u0159ipce s mRNA zaznamenali v\u00fdrazn\u011b z\u00e1va\u017en\u011bj\u0161\u00ed kr\u00e1tkodob\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky, zat\u00edmco celkov\u00fd rozd\u00edl v po\u010dtu p\u0159\u00edpad\u016f ch\u0159ipky mezi ob\u011bma skupinami z\u016fstal mal\u00fd.<\/span><\/p>\n<p><span dir=\"auto\">Studie zve\u0159ejn\u011bn\u00e1 ve \u010dtvrtek vy\u0161et\u0159ila v\u00edce ne\u017e 40 000 dosp\u011bl\u00fdch ve v\u011bku 50 let a star\u0161\u00edch na 301 klinick\u00fdch pracovi\u0161t\u00edch v 11 zem\u00edch severn\u00ed polokoule b\u011bhem ch\u0159ipkov\u00e9 sez\u00f3ny 2024-2025.<\/span><\/p>\n<p><span dir=\"auto\">Nov\u00e1 studie porovn\u00e1vala trivalentn\u00ed vakc\u00ednu proti ch\u0159ipce s mRNA-1010 od spole\u010dnosti Moderna se schv\u00e1len\u00fdmi standardn\u00edmi vakc\u00ednami proti ch\u0159ipce, nikoli se zes\u00edlen\u00fdmi vysokod\u00e1vkov\u00fdmi, adjuvovan\u00fdmi nebo rekombinantn\u00edmi vakc\u00ednami proti ch\u0159ipce, kter\u00e9 jsou ji\u017e doporu\u010dov\u00e1ny pro mnoho star\u0161\u00edch dosp\u011bl\u00fdch.<\/span><\/p>\n<p><span dir=\"auto\">Toto rozli\u0161en\u00ed je d\u016fle\u017eit\u00e9, proto\u017ee studie nemohla prok\u00e1zat, \u017ee vakc\u00edna Moderny byla \u00fa\u010dinn\u011bj\u0161\u00ed ne\u017e \u00fadajn\u011b nej\u00fa\u010dinn\u011bj\u0161\u00ed vakc\u00edny proti ch\u0159ipce, kter\u00e9 jsou v sou\u010dasnosti pro seniory dostupn\u00e9.<\/span><\/p>\n<p><span dir=\"auto\">M\u00edsto toho pouze prok\u00e1zala \u00fadajnou nad\u0159azenost oproti star\u0161\u00edm vakc\u00edn\u00e1m proti ch\u0159ipce se standardn\u00ed d\u00e1vkou.<\/span><\/p>\n<p><span dir=\"auto\">V\u00fdzkumn\u00edci uvedli, \u017ee PCR potvrzen\u00e1, protokolem definovan\u00e1 onemocn\u011bn\u00ed podobn\u00e1 ch\u0159ipce se vyskytla u 2,0 % p\u0159\u00edjemc\u016f mRNA-1010 ve srovn\u00e1n\u00ed s 2,8 % p\u0159\u00edjemc\u016f standardn\u00edch d\u00e1vek vakc\u00edn proti ch\u0159ipce \u2013 absolutn\u00ed rozd\u00edl 0,8 procentn\u00edho bodu, kter\u00fd studie reprezentovala jako relativn\u00ed \u00fa\u010dinnost vakc\u00edny 26,6 %.<\/span><\/p>\n<p><span dir=\"auto\">Pro pr\u016fm\u011brn\u00e9ho \u010dten\u00e1\u0159e to znamen\u00e1, \u017ee titulek \u201eo 26,6 % lep\u0161\u00ed\u201c zn\u00ed mnohem v\u011bt\u0161\u00edm dojmem ne\u017e skute\u010dn\u00fd rozd\u00edl pozorovan\u00fd u studovan\u00e9 populace.<\/span><\/p>\n<p><span dir=\"auto\">U v\u00edce ne\u017e 97 % \u00fa\u010dastn\u00edk\u016f v obou skupin\u00e1ch se prim\u00e1rn\u00ed c\u00edlov\u00fd parametr studie nerozvinul.<\/span><\/p>\n<p><span dir=\"auto\">Z\u00e1rove\u0148 se u 6,4 % p\u0159\u00edjemc\u016f mRNA-1010 vyskytly ne\u017e\u00e1douc\u00ed \u00fa\u010dinky 3. stupn\u011b \u2013 z\u00e1va\u017en\u00e9 reakce, kter\u00e9 naru\u0161uj\u00ed norm\u00e1ln\u00ed aktivitu \u2013 ve srovn\u00e1n\u00ed s 1,0 % p\u0159\u00edjemc\u016f standardn\u00ed d\u00e1vky vakc\u00edny proti ch\u0159ipce.<\/span><\/p>\n<p><span dir=\"auto\">Ve skupin\u011b s mRNA byla tak\u00e9 pozorov\u00e1na v\u00fdznamn\u011b vy\u0161\u0161\u00ed m\u00edra \u00fanavy, bolesti hlavy, bolesti sval\u016f, zimnice a bolesti v m\u00edst\u011b injekce.<\/span><\/p>\n<p><span dir=\"auto\">To znamen\u00e1, \u017ee p\u0159ibli\u017en\u011b 1 ze 16 p\u0159\u00edjemc\u016f vakc\u00edny proti ch\u0159ipce s mRNA zaznamenal z\u00e1va\u017enou kr\u00e1tkodobou reakci, kter\u00e1 byla natolik z\u00e1va\u017en\u00e1, \u017ee naru\u0161ila ka\u017edodenn\u00ed \u010dinnosti, ve srovn\u00e1n\u00ed s p\u0159ibli\u017en\u011b 1 ze 100 p\u0159\u00edjemc\u016f standardn\u00ed vakc\u00edny proti ch\u0159ipce.<\/span><\/p>\n<p><span dir=\"auto\">Studie neprok\u00e1zala \u017e\u00e1dn\u00e9 sn\u00ed\u017een\u00ed \u00famrt\u00ed, hospitalizac\u00ed na jednotk\u00e1ch intenzivn\u00ed p\u00e9\u010de ani z\u00e1va\u017en\u00fdch komplikac\u00ed ch\u0159ipky.<\/span><\/p>\n<p><span dir=\"auto\">Hospitalizace byly hl\u00e1\u0161eny pouze u 4 p\u0159\u00edjemc\u016f mRNA vakc\u00edny a 8 p\u0159\u00edjemc\u016f srovn\u00e1vac\u00ed vakc\u00edny a auto\u0159i uznali, \u017ee studie nebyla pro tyto c\u00edlov\u00e9 parametry dostate\u010dn\u011b navr\u017eena.<\/span><\/p>\n<p><span dir=\"auto\">To znamen\u00e1, \u017ee studie nebyla navr\u017eena tak, aby zjistila, zda mRNA vakc\u00edna proti ch\u0159ipce v\u00fdznamn\u011b sni\u017euje z\u00e1va\u017en\u00e9 komplikace ch\u0159ipky, jako jsou hospitalizace nebo \u00famrt\u00ed.<\/span><\/p>\n<p><span dir=\"auto\">Studie byla financov\u00e1na spole\u010dnostmi Blackstone Life Sciences a Moderna, p\u0159i\u010dem\u017e Moderna byla zodpov\u011bdn\u00e1 za n\u00e1vrh studie, v\u00fdb\u011br m\u00edsta, monitorov\u00e1n\u00ed a anal\u00fdzu dat.<\/span><\/p>\n<p><span dir=\"auto\">Rukopis byl nav\u00edc naps\u00e1n zam\u011bstnanci Moderny s podporou l\u00e9ka\u0159sk\u00fdch autor\u016f financovan\u00fdch Modernou.<\/span><\/p>\n<p><span dir=\"auto\">Jin\u00fdmi slovy, spole\u010dnost, kter\u00e1 produkt vyvinula, tak\u00e9 navrhla studii, analyzovala data a pomohla vytvo\u0159it fin\u00e1ln\u00ed \u010dl\u00e1nek prezentuj\u00edc\u00ed v\u00fdsledky.<\/span><\/p>\n<p><span dir=\"auto\">To vyvol\u00e1v\u00e1 obavy ze st\u0159etu z\u00e1jm\u016f, ale tak\u00e9 to znamen\u00e1, \u017ee samotn\u00e1 spole\u010dnost potvrdila, \u017ee jej\u00ed experiment\u00e1ln\u00ed mRNA vakc\u00edna proti ch\u0159ipce zp\u016fsobila dramaticky vy\u0161\u0161\u00ed m\u00edru z\u00e1va\u017en\u00fdch reakc\u00ed, p\u0159i\u010dem\u017e vedla pouze k mal\u00e9mu absolutn\u00edmu sn\u00ed\u017een\u00ed po\u010dtu p\u0159\u00edpad\u016f ch\u0159ipky definovan\u00fdch symptomy, potvrzen\u00fdch PCR.<\/span><\/p>\n<p><span dir=\"auto\">Spole\u010dnost Moderna byla zalo\u017eena d\u00edky financov\u00e1n\u00ed z Agentury pro pokro\u010dil\u00e9 v\u00fdzkumn\u00e9 projekty ministerstva obrany (DARPA), tajn\u00e9 divize americk\u00e9ho vojensk\u00e9ho v\u00fdzkumu s mal\u00fdm ve\u0159ejn\u00fdm dohledem a histori\u00ed (\u00a0<\/span><a href=\"https:\/\/www.darpa.mil\/research\/programs\/pandemic-prevention-platform\" target=\"_blank\" rel=\"noreferrer noopener\"><span dir=\"auto\">zde<\/span><\/a><span dir=\"auto\">\u00a0) experiment\u016f s dvoj\u00edm pou\u017eit\u00edm.<\/span><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/substackcdn.com\/image\/fetch\/$s_!dFhp!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep\/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F34fc1ec4-bfb8-4b9d-a54c-26bb4602c289_633x841.png\" alt=\"\" width=\"606\" height=\"805\" \/><\/figure>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Z\u00e1va\u017en\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky se vyskytovaly p\u0159ibli\u017en\u011b \u0161estkr\u00e1t \u010dast\u011bji.<\/span><\/strong><\/h2>\n<p><span dir=\"auto\">Jedn\u00edm z nejv\u00fdrazn\u011bj\u0161\u00edch zji\u0161t\u011bn\u00ed byly ne\u017e\u00e1douc\u00ed \u00fa\u010dinky 3. stupn\u011b.<\/span><\/p>\n<p><span dir=\"auto\">Podle \u010dl\u00e1nku:<\/span><\/p>\n<p><em><span dir=\"auto\">\u201eNe\u017e\u00e1douc\u00ed \u00fa\u010dinky 3. stupn\u011b byly hl\u00e1\u0161eny u 6,4 % p\u0159\u00edjemc\u016f mRNA-1010 a u 1,0 % p\u0159\u00edjemc\u016f srovn\u00e1vac\u00edho p\u0159\u00edpravku ve standardn\u00ed d\u00e1vce.\u201c<\/span><\/em><\/p>\n<p><span dir=\"auto\">Reakce 3. stupn\u011b jsou obecn\u011b klasifikov\u00e1ny jako z\u00e1va\u017en\u00e9 reakce, kter\u00e9 naru\u0161uj\u00ed b\u011b\u017en\u00e9 denn\u00ed \u010dinnosti.<\/span><\/p>\n<p><span dir=\"auto\">To znamen\u00e1, \u017ee p\u0159\u00edjemci neuv\u00e1d\u011bli pouze m\u00edrnou bolest nebo \u00fanavu.<\/span><\/p>\n<p><span dir=\"auto\">Jednalo se o reakce, kter\u00e9 byly dostate\u010dn\u011b z\u00e1va\u017en\u00e9, aby naru\u0161ily pr\u00e1ci, ka\u017edodenn\u00ed pohyby nebo b\u011b\u017en\u00e9 denn\u00ed fungov\u00e1n\u00ed.<\/span><\/p>\n<p><span dir=\"auto\">P\u0159ibli\u017en\u011b \u0161estin\u00e1sobn\u00fd n\u00e1r\u016fst z\u00e1va\u017en\u00fdch reakc\u00ed je obzvl\u00e1\u0161t\u011b v\u00fdznamn\u00fd ve srovn\u00e1n\u00ed s relativn\u011b mal\u00fdm absolutn\u00edm poklesem p\u0159\u00edpad\u016f ch\u0159ipky pozorovan\u00fdm ve studii.<\/span><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/substackcdn.com\/image\/fetch\/$s_!_Cje!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep\/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F04787a07-41bc-4ef6-9470-57f74acdb350_1099x601.png\" alt=\"\" width=\"783\" height=\"428\" \/><\/figure>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">\u00danava, bolesti hlavy, bolesti sval\u016f a zimnice se vyskytovaly v\u00fdrazn\u011b \u010dast\u011bji.<\/span><\/strong><\/h2>\n<p><span dir=\"auto\">Studie prok\u00e1zala v\u00fdznamn\u011b vy\u0161\u0161\u00ed m\u00edru odpov\u011bdi ve skupin\u011b s mRNA:<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">Bolest v m\u00edst\u011b injekce: 65,8 % oproti 29,8 % (v\u00edce ne\u017e dvakr\u00e1t \u010dast\u011bji)<\/span><\/li>\n<li><span dir=\"auto\">\u00danava: 45,1 % v porovn\u00e1n\u00ed s 20,3 % (v\u00edce ne\u017e dvojn\u00e1sobek)<\/span><\/li>\n<li><span dir=\"auto\">Bolesti hlavy: 37,8 % ve srovn\u00e1n\u00ed s 18,0 % (v\u00edce ne\u017e dvojn\u00e1sobek)<\/span><\/li>\n<li><span dir=\"auto\">Myalgie: 35,4 % ve srovn\u00e1n\u00ed s 11,6 % (v\u00edce ne\u017e trojn\u00e1sobek)<\/span><\/li>\n<li><span dir=\"auto\">Zimnice: 23 % ve srovn\u00e1n\u00ed se 4 % (t\u00e9m\u011b\u0159 6kr\u00e1t v\u00edce)<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">Tyto v\u00fdsledky ukazuj\u00ed, \u017ee mRNA vakc\u00edna vyvolala v\u00fdrazn\u011b siln\u011bj\u0161\u00ed kr\u00e1tkodob\u00e9 z\u00e1n\u011btliv\u00e9 a syst\u00e9mov\u00e9 reakce ne\u017e konven\u010dn\u00ed vakc\u00edny proti ch\u0159ipce.<\/span><\/p>\n<p><span dir=\"auto\">Auto\u0159i poznamenali, \u017ee v\u011bt\u0161ina reakc\u00ed byla \u201em\u00edrn\u00e1 a\u017e st\u0159edn\u011b z\u00e1va\u017en\u00e1 a p\u0159echodn\u00e1\u201c, ale m\u00edra reakc\u00ed \u00farovn\u011b 3 nazna\u010duje, \u017ee u zna\u010dn\u00e9 podskupiny do\u0161lo k reakc\u00edm dostate\u010dn\u011b z\u00e1va\u017en\u00fdm, aby naru\u0161ily norm\u00e1ln\u00ed aktivitu.<\/span><\/p>\n<figure class=\"wp-block-image aligncenter size-large\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/substackcdn.com\/image\/fetch\/$s_!DpxB!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep\/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0e0a943b-7132-4d80-9f64-eac0c45f92a1_1979x359.png\" alt=\"\" width=\"878\" height=\"159\" \/><\/figure>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Absolutn\u00ed p\u0159\u00ednos byl men\u0161\u00ed ne\u017e 1 procentn\u00ed bod.<\/span><\/strong><\/h2>\n<p><span dir=\"auto\">Prim\u00e1rn\u00edm c\u00edlov\u00fdm parametrem studie bylo dosa\u017eeno:<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">411 z 20 179 p\u0159\u00edjemc\u016f mRNA-1010 (2,0 %)<\/span><\/li>\n<li><span dir=\"auto\">557 z 20 124 p\u0159\u00edjemc\u016f standardn\u00ed d\u00e1vky (2,8 %)<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">To odpov\u00edd\u00e1 absolutn\u00edmu rozd\u00edlu p\u0159ibli\u017en\u011b 0,8 procentn\u00edho bodu.<\/span><\/p>\n<p><span dir=\"auto\">Kdy\u017e 100 lid\u00ed dostalo standardn\u00ed o\u010dkov\u00e1n\u00ed proti ch\u0159ipce, p\u0159ibli\u017en\u011b u 3 se vyvinul ch\u0159ipkov\u00fd faktor, kter\u00fd byl definov\u00e1n jako koncov\u00fd bod studie.<\/span><\/p>\n<p><span dir=\"auto\">Pokud by mRNA vakc\u00ednu dostalo 100 lid\u00ed, byly by jich p\u0159ibli\u017en\u011b 2.<\/span><\/p>\n<p><span dir=\"auto\">To znamen\u00e1, \u017ee \u00fadaj o \u00fa\u010dinnosti uveden\u00fd v titulc\u00edch byl odvozen z relativn\u011b mal\u00e9ho rozd\u00edlu ve skute\u010dn\u00e9 m\u00ed\u0159e onemocn\u011bn\u00ed mezi ob\u011bma skupinami.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Studie se prim\u00e1rn\u011b nezam\u011b\u0159ovala na \u00famrt\u00ed ani na z\u00e1va\u017en\u00e9 p\u0159\u00edpady ch\u0159ipky.<\/span><\/strong><\/h2>\n<p><span dir=\"auto\">Prim\u00e1rn\u00edm c\u00edlov\u00fdm parametrem nebylo \u00famrt\u00ed, p\u0159ijet\u00ed na jednotku intenzivn\u00ed p\u00e9\u010de ani z\u00e1va\u017en\u00e9 komplikace ch\u0159ipky.<\/span><\/p>\n<p><span dir=\"auto\">Jednalo se o \u201ech\u0159ipce podobn\u00e9 onemocn\u011bn\u00ed potvrzen\u00e9 pomoc\u00ed RT-PCR, definovan\u00e9 protokolem\u201c.<\/span><\/p>\n<p><span dir=\"auto\">V publikaci to bylo definov\u00e1no jako pozitivn\u00ed test RT-PCR plus alespo\u0148 jeden syst\u00e9mov\u00fd p\u0159\u00edznak a alespo\u0148 jeden respira\u010dn\u00ed p\u0159\u00edznak.<\/span><\/p>\n<p><span dir=\"auto\">Podle protokolu \u00fa\u010dastn\u00edci pot\u0159ebovali pouze:<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">pozitivn\u00ed RT-PCR test<\/span><\/li>\n<li><span dir=\"auto\">syst\u00e9mov\u00fd p\u0159\u00edznak<\/span><\/li>\n<li><span dir=\"auto\">respira\u010dn\u00ed p\u0159\u00edznak<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">pova\u017eovat za p\u0159\u00edpad prim\u00e1rn\u00edho c\u00edlov\u00e9ho parametru.<\/span><\/p>\n<p><span dir=\"auto\">To znamen\u00e1, \u017ee studie zachytila \u200b\u200bp\u0159edev\u0161\u00edm symptomatick\u00e1 PCR pozitivn\u00ed onemocn\u011bn\u00ed, a nikoli to, zda o\u010dkov\u00e1n\u00ed zabr\u00e1nilo nejnebezpe\u010dn\u011bj\u0161\u00edm p\u0159\u00edpad\u016fm ch\u0159ipky.<\/span><\/p>\n<p><span dir=\"auto\">Znamen\u00e1 to tak\u00e9, \u017ee tvrzen\u00ed o \u00fa\u010dinnosti studie, kter\u00e1 byla zd\u016fraz\u0148ov\u00e1na v titulc\u00edch, siln\u011b z\u00e1visela na testovac\u00ed technologii RT-PCR, o kter\u00e9 kritici dlouho tvrdili, \u017ee m\u016f\u017ee v\u00e9st k zav\u00e1d\u011bj\u00edc\u00edm nebo klinicky sporn\u00fdm \u201epozitivn\u00edm\u201c v\u00fdsledk\u016fm v z\u00e1vislosti na testovac\u00edch prahov\u00fdch hodnot\u00e1ch, amplifika\u010dn\u00edch cyklech, riziku kontaminace a standardech hodnocen\u00ed.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Po\u010det hospitalizac\u00ed byl extr\u00e9mn\u011b n\u00edzk\u00fd.<\/span><\/strong><\/h2>\n<p><span dir=\"auto\">Studie uv\u00e1d\u00ed:<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">4 hospitalizace ve skupin\u011b mRNA<\/span><\/li>\n<li><span dir=\"auto\">8 hospitalizac\u00ed ve srovn\u00e1vac\u00ed skupin\u011b se standardn\u00ed d\u00e1vkou<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">Auto\u0159i p\u0159ipustili, \u017ee studie \u201enebyla pro tyto c\u00edlov\u00e9 parametry dostate\u010dn\u011b navr\u017eena\u201c.<\/span><\/p>\n<p><span dir=\"auto\">Po\u010det hospitalizac\u00ed byl proto p\u0159\u00edli\u0161 mal\u00fd na to, aby spolehliv\u011b prok\u00e1zal v\u00fdznamnou ochranu p\u0159ed z\u00e1va\u017en\u00fdmi komplikacemi ch\u0159ipky.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Moderna neporovn\u00e1vala vakc\u00ednu s \u201enej\u00fa\u010dinn\u011bj\u0161\u00edmi\u201c existuj\u00edc\u00edmi vakc\u00ednami proti ch\u0159ipce.<\/span><\/strong><\/h2>\n<p><span dir=\"auto\">Studie porovn\u00e1vala mRNA-1010 se schv\u00e1len\u00fdmi standardn\u00edmi d\u00e1vkami vakc\u00edn proti ch\u0159ipce, v\u010detn\u011b produkt\u016f typu Fluarix.<\/span><\/p>\n<p><span dir=\"auto\">Auto\u0159i uznali, \u017ee n\u011bkter\u00e9 zem\u011b doporu\u010duj\u00ed star\u0161\u00edm dosp\u011bl\u00fdm zes\u00edlen\u00e9 o\u010dkov\u00e1n\u00ed proti ch\u0159ipce, ale p\u0159esto zvolili standardn\u00ed srovn\u00e1vac\u00ed vakc\u00ednu.<\/span><\/p>\n<p><span dir=\"auto\">To znamen\u00e1, \u017ee studie nemohla prok\u00e1zat, \u017ee mRNA vakc\u00edna byla lep\u0161\u00ed ne\u017e vysokod\u00e1vkov\u00e9 nebo zes\u00edlen\u00e9 vakc\u00edny proti ch\u0159ipce, kter\u00e9 se ji\u017e b\u011b\u017en\u011b doporu\u010duj\u00ed senior\u016fm.<\/span><\/p>\n<p><span dir=\"auto\">Toto je jedno z nejv\u011bt\u0161\u00edch omezen\u00ed studie, proto\u017ee prezentace \u201evynikaj\u00edc\u00ed\u201c \u00fa\u010dinnosti vakc\u00edny v publikaci by mohla \u010dten\u00e1\u0159e uv\u00e9st v omyl a zma\u0159it je tak, \u017ee vakc\u00edna celkov\u011b p\u0159ekonala \u00fadajn\u011b \u201enejlep\u0161\u00ed\u201c dostupn\u00e9 vakc\u00edny proti ch\u0159ipce \u2013 co\u017e studie neprok\u00e1zala.<\/span><\/p>\n<p><span dir=\"auto\">Studie nav\u00edc nezahrnovala skupinu s placebem ve skute\u010dn\u00e9m fyziologick\u00e9m roztoku \u2013 v\u0161eobecn\u011b pova\u017eovanou za v\u011bdeck\u00fd zlat\u00fd standard pro ur\u010den\u00ed skute\u010dn\u00e9 bezpe\u010dnosti a \u00fa\u010dinnosti p\u0159\u00edpravku \u2013 co\u017e znamen\u00e1, \u017ee \u00fa\u010dastn\u00edci byli porovn\u00e1v\u00e1ni pouze s jin\u00fdmi vakc\u00ednami proti ch\u0159ipce, a nikoli s inertn\u00ed, neo\u010dkovanou kontroln\u00ed skupinou.<\/span><\/p>\n<p><span dir=\"auto\">Jin\u00fdmi slovy, studie byla navr\u017eena tak, aby porovnala jednu o\u010dkovac\u00ed strategii s druhou, a nikoliv aby definitivn\u011b ur\u010dila pln\u00fd rozsah \u0161kod, vedlej\u0161\u00edch \u00fa\u010dink\u016f nebo \u00fadajn\u00fdch p\u0159\u00ednos\u016f, kter\u00e9 by mohly nastat, kdyby se o\u010dkov\u00e1n\u00ed proti ch\u0159ipce zcela vynechalo.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">\u00da\u010dinnost u k\u0159ehk\u00fdch star\u0161\u00edch osob z\u016fstala nejist\u00e1.<\/span><\/strong><\/h2>\n<p><span dir=\"auto\">U k\u0159ehk\u00fdch \u00fa\u010dastn\u00edk\u016f ve v\u011bku 65 let a star\u0161\u00edch se odhadovan\u00fd interval spolehlivosti pro relativn\u00ed \u00fa\u010dinnost vakc\u00edny pohyboval od -37,1 % do +64,6 %.<\/span><\/p>\n<p><span dir=\"auto\">Toto extr\u00e9mn\u011b \u0161irok\u00e9 rozp\u011bt\u00ed znamen\u00e1, \u017ee studie nemohla jasn\u011b ur\u010dit, jak dob\u0159e vakc\u00edna fungovala u n\u011bkter\u00fdch star\u0161\u00edch \u00fa\u010dastn\u00edk\u016f, kte\u0159\u00ed byli nejv\u00edce ohro\u017eeni zdravotn\u00edm stavem.<\/span><\/p>\n<p><span dir=\"auto\">Statisticky vzato byla data v t\u00e9to podskupin\u011b velmi nejist\u00e1.<\/span><\/p>\n<h2 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Moderna studii navrhla, \u0159\u00eddila, analyzovala a napsala.<\/span><\/strong><\/h2>\n<p><span dir=\"auto\">Publikace uv\u00e1d\u00ed:<\/span><\/p>\n<p><em><span dir=\"auto\">\u201eSponzor, spole\u010dnost Moderna, byl zodpov\u011bdn\u00fd za cel\u00fd n\u00e1vrh studie, v\u00fdb\u011br studijn\u00edch center, monitorov\u00e1n\u00ed a anal\u00fdzu dat.\u201c<\/span><\/em><\/p>\n<p><span dir=\"auto\">Tak\u00e9 uv\u00e1d\u00ed:<\/span><\/p>\n<p><em><span dir=\"auto\">\u201eRukopis napsali zam\u011bstnanci Moderny.\u201c<\/span><\/em><\/p>\n<p><em><span dir=\"auto\">Studie byla \u201epodporov\u00e1na spole\u010dnostmi Blackstone Life Sciences a Moderna\u201c.<\/span><\/em><\/p>\n<p><span dir=\"auto\">To znamen\u00e1, \u017ee samotn\u00fd v\u00fdrobce hr\u00e1l \u00fast\u0159edn\u00ed roli t\u00e9m\u011b\u0159 ve v\u0161ech podstatn\u00fdch aspektech studie, v\u010detn\u011b:<\/span><\/p>\n<ul>\n<li><span dir=\"auto\">Struktura studie<\/span><\/li>\n<li><span dir=\"auto\">Dohled nad sb\u011brem dat<\/span><\/li>\n<li><span dir=\"auto\">statistick\u00e1 anal\u00fdza<\/span><\/li>\n<li><span dir=\"auto\">Vznik rukopisu<\/span><\/li>\n<\/ul>\n<p><span dir=\"auto\">Kritici tvrd\u00ed, \u017ee tato \u00farove\u0148 kontroly ze strany sponzora vyvol\u00e1v\u00e1 obavy ohledn\u011b nez\u00e1vislosti a objektivity p\u0159i prezentaci a interpretaci v\u00fdsledk\u016f.<\/span><\/p>\n<p><span dir=\"auto\">Znamen\u00e1 to tak\u00e9, \u017ee samotn\u00e1 spole\u010dnost p\u0159\u00edmo uzn\u00e1v\u00e1 a zve\u0159ej\u0148uje zji\u0161t\u011bn\u00ed studie, kter\u00e1 ukazuj\u00ed dramaticky zv\u00fd\u0161enou m\u00edru z\u00e1va\u017en\u00fdch vedlej\u0161\u00edch \u00fa\u010dink\u016f, omezen\u00fd absolutn\u00ed p\u0159\u00ednos a nedostatek d\u016fkaz\u016f o v\u00fdznamn\u00e9m sn\u00ed\u017een\u00ed hospitalizac\u00ed nebo \u00famrt\u00ed.<\/span><\/p>\n<h3 class=\"wp-block-heading has-medium-font-size\"><strong><span dir=\"auto\">Z\u00e1v\u011br<\/span><\/strong><\/h3>\n<p><span dir=\"auto\">Vlastn\u00ed studie f\u00e1ze 3 spole\u010dnosti Moderna uk\u00e1zala, \u017ee experiment\u00e1ln\u00ed mRNA vakc\u00edna proti ch\u0159ipce t\u00e9to spole\u010dnosti zp\u016fsobila dramaticky vy\u0161\u0161\u00ed m\u00edru z\u00e1va\u017en\u00fdch ne\u017e\u00e1douc\u00edch \u00fa\u010dink\u016f, p\u0159i\u010dem\u017e vedla pouze k mal\u00e9mu absolutn\u00edmu sn\u00ed\u017een\u00ed po\u010dtu symptomov\u011b definovan\u00fdch, PCR potvrzen\u00fdch p\u0159\u00edpad\u016f ch\u0159ipky \u2013 ani\u017e by prok\u00e1zala v\u00fdznamn\u00e9 sn\u00ed\u017een\u00ed hospitalizac\u00ed, \u00famrt\u00ed nebo nejnebezpe\u010dn\u011bj\u0161\u00edch komplikac\u00ed ch\u0159ipky.<\/span><\/p>\n<p><span dir=\"auto\">Studie se tak\u00e9 vyhnula srovn\u00e1n\u00ed s placebem s fyziologick\u00fdm roztokem a nej\u00fa\u010dinn\u011bj\u0161\u00edmi zes\u00edlen\u00fdmi vakc\u00ednami proti ch\u0159ipce, kter\u00e9 jsou ji\u017e doporu\u010dov\u00e1ny pro seniory. To znamen\u00e1, \u017ee studie nikdy nemohla prok\u00e1zat, zda produkt nab\u00edz\u00ed v\u00fdznamnou v\u00fdhodu oproti p\u0159edchoz\u00edmu o\u010dkov\u00e1n\u00ed proti ch\u0159ipce nebo \u00fadajn\u011b \u201enejlep\u0161\u00edm\u201c existuj\u00edc\u00edm vakc\u00edn\u00e1m proti ch\u0159ipce.<\/span><\/p>\n<p><strong><em><span dir=\"auto\">Od Jona Fleetwooda<\/span><\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div class=\"elementor-element elementor-element-8c57238 quelle dc-has-condition dc-condition-empty elementor-widget elementor-widget-heading\" data-id=\"8c57238\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n<div class=\"elementor-widget-container\">\n<h3 class=\"elementor-heading-title elementor-size-default\"><span style=\"font-size: 10pt;\"><a href=\"https:\/\/jonfleetwood.substack.com\/p\/moderna-confirms-its-new-mrna-1010\" target=\"_blank\" rel=\"nofollow noopener\"><span dir=\"auto\">Zdroj<\/span><\/a><\/span><\/h3>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Neexistuj\u00ed \u017e\u00e1dn\u00e9 d\u016fkazy o tom, \u017ee by o\u010dkov\u00e1n\u00ed vedlo ke sn\u00ed\u017een\u00ed \u00famrt\u00ed nebo po\u010dtu z\u00e1va\u017en\u00fdch&#8230;<\/p>\n","protected":false},"author":2,"featured_media":106309,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[1208,573,1301,651,21],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/106308"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=106308"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/106308\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/106309"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=106308"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=106308"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=106308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}