{"id":101450,"date":"2026-03-10T00:15:16","date_gmt":"2026-03-09T23:15:16","guid":{"rendered":"https:\/\/www.infokuryr.cz\/n\/?p=101450"},"modified":"2026-03-09T13:19:48","modified_gmt":"2026-03-09T12:19:48","slug":"recenzovany-clanek-dochazi-k-zaveru-ze-mrna-vakciny-jsou-technologii-pozmenujici-geny","status":"publish","type":"post","link":"https:\/\/www.infokuryr.cz\/n\/2026\/03\/10\/recenzovany-clanek-dochazi-k-zaveru-ze-mrna-vakciny-jsou-technologii-pozmenujici-geny\/","title":{"rendered":"Recenzovan\u00fd \u010dl\u00e1nek doch\u00e1z\u00ed k z\u00e1v\u011bru, \u017ee mRNA \u201evakc\u00edny\u201c jsou technologi\u00ed pozm\u011b\u0148uj\u00edc\u00ed geny"},"content":{"rendered":"
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Za\u0159azeno pod: extr\u00e9mn\u011b znepokojiv\u00e9.<\/span><\/strong><\/h3>\n

Tento \u010dl\u00e1nek se p\u016fvodn\u011b objevil na Focal Points a je publikov\u00e1n s jeho svolen\u00edm.<\/span><\/em><\/p>\n

Hostuj\u00edc\u00ed \u010dl\u00e1nek od\u00a0<\/span><\/strong>Nicolase Hulschera, MPH<\/span><\/strong><\/p>\n

Multiomick\u00e9 d\u016fkazy ukazuj\u00ed, \u017ee vakc\u00edny s genov\u00fdm transferem mRNA z\u00e1sadn\u011b p\u0159eprogramuj\u00ed expresi lidsk\u00fdch gen\u016f v mnoha biologick\u00fdch syst\u00e9mech \u2013 co\u017e ospravedl\u0148uje okam\u017eit\u00e9 pozastaven\u00ed cel\u00e9 mRNA platformy.<\/span><\/em><\/h4>\n

N\u00e1\u0161 ned\u00e1vn\u00fd recenzovan\u00fd \u010dl\u00e1nek \u201e\u00a0<\/span>Zm\u011bny genov\u00e9 exprese vyvolan\u00e9 mRNA vakc\u00ednami<\/span><\/strong><\/a>\u00a0\u201c, publikovan\u00fd v \u010dasopise Journal of American Physicians and Surgeons, poskytuje p\u0159esv\u011bd\u010div\u00e9 d\u016fkazy o tom, \u017ee\u00a0<\/span>mRNA vakc\u00edny funguj\u00ed prost\u0159ednictv\u00edm mechanismu \u00fa\u010dinku pozm\u011b\u0148uj\u00edc\u00edho geny (MOA), kter\u00fd z\u00e1sadn\u011b p\u0159eprogramuje expresi lidsk\u00fdch gen\u016f na v\u00edce biologick\u00fdch \u00farovn\u00edch.<\/span><\/strong><\/p>\n

Rukopis McCullough Foundation-Neo7Bioscience, jeho\u017e autory jsou Nicolas Hulscher (j\u00e1), Dr. Peter A. McCullough a Dr. John Catanzaro, shrnuje nejnov\u011bj\u0161\u00ed multiomick\u00e9 d\u016fkazy u lid\u00ed, kter\u00e9 prokazuj\u00ed koordinovan\u00e9 transkriptomick\u00e9, proteomick\u00e9 a genomick\u00e9 zm\u011bny po o\u010dkov\u00e1n\u00ed mRNA.<\/span><\/p>\n

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Technologie mRNA m\u011bn\u00ed genovou expresi nap\u0159\u00ed\u010d n\u011bkolika biologick\u00fdmi \u00farovn\u011bmi.<\/span><\/strong><\/h3>\n

D\u016fkazy se nyn\u00ed vztahuj\u00ed na t\u0159i d\u016fle\u017eit\u00e9 biologick\u00e9 syst\u00e9my:<\/span><\/p>\n

\u2022\u00a0<\/span>Transkriptomika<\/span><\/strong>\u00a0(genov\u00e1 exprese)<\/span><\/p>\n

\u2022\u00a0<\/span>Proteomika<\/span><\/strong>\u00a0(produkce b\u00edlkovin)<\/span><\/p>\n

\u2022\u00a0<\/span>Genomika<\/span><\/strong>\u00a0(interakce DNA)<\/span><\/p>\n

Technologie mRNA interaguje s celou molekul\u00e1rn\u00ed architekturou lidsk\u00e9 biologie. Aktivn\u011b m\u011bn\u00ed s\u00edt\u011b genov\u00e9 exprese hostitele a ovliv\u0148uje metabolismus, regulaci imunitn\u00edho syst\u00e9mu a bun\u011b\u010dn\u00e9 stresov\u00e9 dr\u00e1hy.<\/span><\/p>\n

Transkriptomick\u00e9 d\u016fkazy ukazuj\u00ed na celosyst\u00e9mov\u00e9 p\u0159eprogramov\u00e1n\u00ed gen\u016f<\/span><\/strong><\/h3>\n

Sekvenov\u00e1n\u00ed RNA u jedinc\u016f, u kter\u00fdch se po o\u010dkov\u00e1n\u00ed mRNA objevily nov\u00e9 ne\u017e\u00e1douc\u00ed \u00fa\u010dinky, odhalilo\u00a0<\/span>rozs\u00e1hl\u00e9 posuny v s\u00edt\u00edch genov\u00e9 exprese<\/span><\/strong>\u00a0.<\/span><\/p>\n

Mezi nejd\u016fle\u017eit\u011bj\u0161\u00ed zm\u011bny pat\u0159ily sign\u00e1ln\u00ed dr\u00e1hy, kter\u00e9 \u0159\u00edd\u00ed n\u00e1sleduj\u00edc\u00ed:<\/span><\/p>\n

\u2022 mitochondri\u00e1ln\u00ed dysfunkce<\/span><\/strong><\/p>\n

\u2022 po\u0161kozen\u00ed ribozom\u016f<\/span><\/strong><\/p>\n

\u2022 proteazom\u00e1ln\u00ed stres<\/span><\/strong><\/p>\n

\u2022 Dysregulace transla\u010dn\u00ed kontroly<\/span><\/strong><\/p>\n

\u2022 Naru\u0161en\u00ed metabolick\u00e9 dr\u00e1hy<\/span><\/strong><\/p>\n

Tyto syst\u00e9my p\u0159edstavuj\u00ed centr\u00e1ln\u00ed bun\u011b\u010dn\u00e9 mechanismy, nejen imunitn\u00ed sign\u00e1ly. Klasick\u00e9 z\u00e1n\u011btliv\u00e9 dr\u00e1hy tvo\u0159ily pouze malou \u010d\u00e1st naru\u0161en\u00fdch genov\u00fdch s\u00edt\u00ed. Dominantn\u00edm sign\u00e1lem byla koordinovan\u00e1 restrukturalizace bun\u011b\u010dn\u00fdch genov\u00fdch regula\u010dn\u00edch program\u016f.<\/span><\/p>\n

Proteomick\u00e9 d\u016fkazy potvrzuj\u00ed prob\u00edhaj\u00edc\u00ed molekul\u00e1rn\u00ed zm\u011bny<\/span><\/strong><\/h3>\n

Longitudin\u00e1ln\u00ed anal\u00fdza zdrav\u00fdch p\u0159\u00edjemc\u016f mRNA vakc\u00edny sledovala\u00a0<\/span>342 plazmatick\u00fdch protein\u016f po dobu 24 t\u00fddn\u016f<\/span><\/strong>\u00a0. V\u00fdsledky uk\u00e1zaly:<\/span><\/p>\n

214 z 342 protein\u016f pro\u0161lo statisticky v\u00fdznamn\u00fdmi zm\u011bnami z\u00e1visl\u00fdmi na \u010dase.<\/span><\/strong><\/p>\n

Mezi posti\u017een\u00e9 biologick\u00e9 syst\u00e9my pat\u0159ily:<\/span><\/p>\n

\u2022 Dr\u00e1hy aktivace komplementu<\/span><\/strong><\/p>\n

\u2022 Metabolick\u00e1 regulace<\/span><\/strong><\/p>\n

\u2022 endokrinn\u00ed signalizace<\/span><\/strong><\/p>\n

\u2022 Vitam\u00edny a kofaktorov\u00e9 dr\u00e1hy<\/span><\/strong><\/p>\n

K nejv\u011bt\u0161\u00edm molekul\u00e1rn\u00edm posun\u016fm do\u0161lo 16 a\u017e 24 t\u00fddn\u016f po o\u010dkov\u00e1n\u00ed, co\u017e ukazuje, \u017ee tyto \u00fa\u010dinky nejsou do\u010dasn\u00fdmi imunitn\u00edmi reakcemi.<\/span><\/p>\n

D\u016fkazy o p\u0159\u00edm\u00e9 molekul\u00e1rn\u00ed interakci s genomem<\/span><\/strong><\/h3>\n

Integrovan\u00e1 multiomick\u00e1 anal\u00fdza pacienta, u kter\u00e9ho se po o\u010dkov\u00e1n\u00ed mRNA rozvinul agresivn\u00ed karcinom mo\u010dov\u00e9ho m\u011bch\u00fd\u0159e ve \u010dtvrt\u00e9m st\u00e1diu, odhalila z\u00e1va\u017en\u00e9 molekul\u00e1rn\u00ed poruchy, v\u010detn\u011b:<\/span><\/p>\n

\u2022\u00a0<\/span>Dysregulace onkogenn\u00edch \u0159\u00eddic\u00edch gen\u016f<\/span><\/strong>\u00a0(v\u010detn\u011b KRAS, PIK3CA a ATM)<\/span><\/p>\n

\u2022\u00a0<\/span>Poru\u0161en\u00ed drah opravy DNA<\/span><\/strong>\u00a0a genomick\u00e1 nestabilita<\/span><\/p>\n

\u2022\u00a0<\/span>rozs\u00e1hl\u00e9 transkrip\u010dn\u00ed p\u0159eprogramov\u00e1n\u00ed nap\u0159\u00ed\u010d bun\u011b\u010dn\u00fdmi s\u00edt\u011bmi<\/span><\/strong><\/p>\n

\u2022\u00a0<\/span>Detekce chim\u00e9rick\u00e9 sekvence hostitelsk\u00e9ho vektoru, kter\u00e1 odpov\u00edd\u00e1 otev\u0159en\u00e9mu \u010dtec\u00edmu r\u00e1mci vakcina\u010dn\u00edho hrotu ve fragmentech n\u00e1dorov\u00e9 DNA \u2013 co\u017e nazna\u010duje mo\u017enou integraci genetick\u00e9ho materi\u00e1lu vakc\u00edny do lidsk\u00e9ho genomu<\/span><\/strong><\/p>\n

Tento p\u0159\u00edpad poskytuje p\u0159\u00edm\u00fd d\u016fkaz molekul\u00e1rn\u00ed interakce mezi sekvencemi gen\u016f vakc\u00edny a lidskou DNA.<\/span><\/p>\n

mRNA platformy funguj\u00ed jako technologie pro editaci gen\u016f<\/span><\/strong><\/h3>\n

Celkov\u011b vzato d\u016fkazy ukazuj\u00ed, \u017ee injekce mRNA nefunguj\u00ed jako jednoduch\u00e9 vakc\u00edny. Funguj\u00ed jako\u00a0<\/span>genov\u00e9 technologie schopn\u00e9 zm\u011bnit syst\u00e9my genov\u00e9 exprese hostitele.<\/span><\/strong><\/p>\n

D\u016fsledky sahaj\u00ed daleko za r\u00e1mec injekc\u00ed mRNA COVID-19. Stejn\u00e1 platforma pro editaci gen\u016f se v sou\u010dasn\u00e9 dob\u011b roz\u0161i\u0159uje o:<\/span><\/p>\n

\u2022 injekce mRNA proti rakovin\u011b<\/span><\/p>\n

\u2022 injekce mRNA ch\u0159ipky<\/span><\/p>\n

\u2022 injekce mRNA-RSV<\/span><\/p>\n

\u2022 Personalizovan\u00e1 mRNA terapie<\/span><\/p>\n

\u2022 technologie samoposiluj\u00edc\u00ed RNA<\/span><\/p>\n

Tyto technologie byly nicm\u00e9n\u011b nasazeny po cel\u00e9m sv\u011bt\u011b bez povinn\u00e9ho molekul\u00e1rn\u00edho monitorov\u00e1n\u00ed pro sledov\u00e1n\u00ed zm\u011bn v genov\u00e9 expresi, genomick\u00e9ho monitorov\u00e1n\u00ed integra\u010dn\u00edch ud\u00e1lost\u00ed a technick\u00fdch biologick\u00fdch ochrann\u00fdch opat\u0159en\u00ed schopn\u00fdch zastavit abnorm\u00e1ln\u00ed expresn\u00ed kask\u00e1dy.<\/span><\/p>\n

Jin\u00fdmi slovy, pro miliardy lid\u00ed byla zavedena v\u00fdkonn\u00e1 platforma pro p\u0159enos gen\u016f bez z\u00e1kladn\u00edch molekul\u00e1rn\u00edch bezpe\u010dnostn\u00edch opat\u0159en\u00ed, kter\u00e1 jsou u genov\u00fdch technologi\u00ed obvykle vy\u017eadov\u00e1na.<\/span><\/p>\n

Jak jsme uvedli v publikaci,<\/span><\/p>\n

Bez povinn\u00e9ho molekul\u00e1rn\u00edho monitorov\u00e1n\u00ed, vymahateln\u00fdch bezpe\u010dnostn\u00edch opat\u0159en\u00ed a integrovan\u00fdch biologick\u00fdch z\u00e1ruk, kter\u00e9 by zabr\u00e1nily abnorm\u00e1ln\u00ed genov\u00e9 expresi, z\u016fst\u00e1vaj\u00ed platformy jako mRNA vakc\u00edny pro \u010dlov\u011bka ze sv\u00e9 podstaty nebezpe\u010dn\u00e9. Proto je nezbytn\u00e9 okam\u017eit\u00e9 a komplexn\u00ed pozastaven\u00ed jejich pou\u017e\u00edv\u00e1n\u00ed u lid\u00ed.<\/span><\/em><\/p>\n

Nicolas Hulscher, MPH \u2013 epidemiolog a spr\u00e1vce nadace, McCullough Foundation<\/span><\/p>\n<\/div>\n<\/div>\n

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Zdroj<\/span><\/a><\/span><\/h3>\n

 <\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Za\u0159azeno pod: extr\u00e9mn\u011b znepokojiv\u00e9. Tento \u010dl\u00e1nek se p\u016fvodn\u011b objevil na Focal Points a je publikov\u00e1n…<\/p>\n","protected":false},"author":2,"featured_media":101451,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[7],"tags":[895,694,839,651],"_links":{"self":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/101450"}],"collection":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/comments?post=101450"}],"version-history":[{"count":0,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/posts\/101450\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media\/101451"}],"wp:attachment":[{"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/media?parent=101450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/categories?post=101450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.infokuryr.cz\/n\/wp-json\/wp\/v2\/tags?post=101450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}